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Antioxidant effects and its mechanism of Cheongsimyeonjatang in Sasang Constitutional Medicine

  • Journal of Sasang Constitutional Medicine
  • Abbr : J Sasang Constitut Med
  • 2004, 16(1), pp.130-147
  • Publisher : The Society Of Sasang Constitutional Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine
  • Received : March 31, 2004
  • Accepted : March 31, 2004
  • Published : April 1, 2004

Han Byung-sam 1 Bae,Young-Chun 2 Song Seung-Yun 3 Park Hye Sun 3 Lee Jae Heung 3 Kim Kyung-Yo 3

1원광대학교 대학원 사상의학교실
2원광대학교
3

ABSTRACT

To investigate the antioxidant capacity of traditional Korean herb medicines, water extracts from 42 species which has been used for the Taeum constitution of Sasang Medicine, were tested on their antioxidant activity using radical scavenging effects against ABTS. Some Of them showed strong antioxidant capacities at 50㎍concentration. And, antioxidant capacities of 2 prescriptions extract of Sasang Medicine, Cheongsimyeonja-tang and Yeoldahanso-tang, in the different concentration (10㎍, 50㎍, and 100㎍) were determined. At the same time, the antiperoxidation effects of these 2 prescriptions extract were determined. Lipid peroxidation in brain homogenates induced by NADPH and ADP-Fe2+ was strongly inhibited by Cheongsimyeonja-tang in vitro. The above-mentioned 2 prescriptions are a potent antioxidant capacity and antiperoxidation activity, further investigation into the in vivo antioxidant therapeutic potential for treatment of human disorders in brain tissue.

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