@article{ART002802305},
author={joo hee kim and Park Seong-sik},
title={The Effect of Chungpyesagantang on Lipopolysaccharide induced Arthritis in Mice},
journal={Journal of Sasang Constitutional Medicine},
issn={1226-4075},
year={2002},
volume={14},
number={3},
pages={114-131}
TY - JOUR
AU - joo hee kim
AU - Park Seong-sik
TI - The Effect of Chungpyesagantang on Lipopolysaccharide induced Arthritis in Mice
JO - Journal of Sasang Constitutional Medicine
PY - 2002
VL - 14
IS - 3
PB - The Society Of Sasang Constitutional Medicine
SP - 114
EP - 131
SN - 1226-4075
AB - Abstract 1. PURPOSE : The purpose of this study is to investigate the effect of Chungpyesagantang on LPS induced Arthritis in Mice. 2. METHOD : All the BALB/C Mice used in this study were 4wks of age at the start of the experiment. The experimental model of Arthritis was induced by injectection of 300μg/kg LPS in mice knee joint. The experiment was compare daily CS treatment group after Arthritis elicitation with Arthritis elicitated group at day 4, 7, 14 after Arthritis elicitation. 3. RESULTS 1) The hyperplasia of synoviocytes of CS treatment group after Arthritis elicitation is soften than Arthritis elicitated group. 2) The aggregation of collagen fibers CS treatment group after Arthritis elicitation is decreased than Arthritis elicitated group. 3) The distribution of TUNEL positive cells(apoptotic cell) of CS treatment group was remarkably increased than Arthritis elicitated group. 4) The distribution of TNF−α, NF−κBp50, COX-2 positive cells of CS treatment group after Arthritis elicitation in synovial membrane was decreased than Arthritis elicitated group. 5) The distribution of IL−2R−α, ICAM-1 positive cells of CS treatment group after Arthritis elicitation in apical surface of synovial membrane was decreased than Arthritis elicitated group. 6) The distribution of NF−κBp50, IL−2R−α in common iliac lymph node of CS treatment group after Arthritis elicitation positive cells was decreased than Arthritis elicitated group. 4. CONCLUSION : As a result of these experimental results, it may be concluded that Chungpyesagantang used for treatment of LPS induced Arthritis in Mice. Inflamation activity in CS treatment group after Arthritis elicitation was decreased than Arthritis elicitated group.
KW - Chungpyesagantang;LPS induced Arthritis;TNF−α;$NF-{;kappa}B;;p50$;COX-2;IL−2R−α;ICAM-1
DO -
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ER -
joo hee kim and Park Seong-sik. (2002). The Effect of Chungpyesagantang on Lipopolysaccharide induced Arthritis in Mice. Journal of Sasang Constitutional Medicine, 14(3), 114-131.
joo hee kim and Park Seong-sik. 2002, "The Effect of Chungpyesagantang on Lipopolysaccharide induced Arthritis in Mice", Journal of Sasang Constitutional Medicine, vol.14, no.3 pp.114-131.
joo hee kim, Park Seong-sik "The Effect of Chungpyesagantang on Lipopolysaccharide induced Arthritis in Mice" Journal of Sasang Constitutional Medicine 14.3 pp.114-131 (2002) : 114.
joo hee kim, Park Seong-sik. The Effect of Chungpyesagantang on Lipopolysaccharide induced Arthritis in Mice. 2002; 14(3), 114-131.
joo hee kim and Park Seong-sik. "The Effect of Chungpyesagantang on Lipopolysaccharide induced Arthritis in Mice" Journal of Sasang Constitutional Medicine 14, no.3 (2002) : 114-131.
joo hee kim; Park Seong-sik. The Effect of Chungpyesagantang on Lipopolysaccharide induced Arthritis in Mice. Journal of Sasang Constitutional Medicine, 14(3), 114-131.
joo hee kim; Park Seong-sik. The Effect of Chungpyesagantang on Lipopolysaccharide induced Arthritis in Mice. Journal of Sasang Constitutional Medicine. 2002; 14(3) 114-131.
joo hee kim, Park Seong-sik. The Effect of Chungpyesagantang on Lipopolysaccharide induced Arthritis in Mice. 2002; 14(3), 114-131.
joo hee kim and Park Seong-sik. "The Effect of Chungpyesagantang on Lipopolysaccharide induced Arthritis in Mice" Journal of Sasang Constitutional Medicine 14, no.3 (2002) : 114-131.
