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Effects of Cheongsimyeonja-tang water extract on the Cultured Primary Hippocampal Cell Damaged by XO/HX

  • Journal of Sasang Constitutional Medicine
  • Abbr : J Sasang Constitut Med
  • 2002, 14(3), pp.132-145
  • Publisher : The Society Of Sasang Constitutional Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine
  • Received : December 31, 2002
  • Accepted : December 31, 2002
  • Published : December 31, 2002

Hwang Seung Yeon 1 Lee Jae Heung 2 Kim Hyoung-soon 3 Bae,Young-Chun 1 kim kyung yo 1 Won,Kyoung-Sook 4

1원광대학교
2원광대
3원광대학교 한의과대학 사상체질과
4계명대학교

ABSTRACT

The purpose of this study is to examine the toxic effects caused by xanthine oxidase/hypoxanthine(XO/HX) and the effects of herbal extracts such as Cheongsimyeonjatang(CYT) on the treatment of the toxic effects. For this purpose, experiments with the cultured hippocampal cells from new born mice were done. The results of these experiments were as follows. 1. XO/HX, a oxygen radical-generating system, decreased the survival rates of the cultured cells on MTT assay and NR assay, protein synthesis, and amounts of neurofilaments. 2. CYT have the efficacy of increasing protein synthesis decreased by XO/HX. 3. CYT have the efficacy. of increasing the amount of neurofilaments decreased by XO/HX. From the above results, it is suggested that Cheongsimyeonjatang (CYT) have marked efficacy as a protection for the damages caused by the XO/HX-mediated oxidative stress.

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