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Genetic Analysis of Sasang Constitution by Amp-FLP Method

  • Journal of Sasang Constitutional Medicine
  • Abbr : J Sasang Constitut Med
  • 1997, 9(2), pp.163-173
  • Publisher : The Society Of Sasang Constitutional Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine
  • Received : December 30, 1997
  • Accepted : December 30, 1997
  • Published : December 30, 1997

Cho Dong-wuk 1 Ahn, Sun-Kyung 2 Kim, Dae-Won 2 Kim Dae won 2 Ji Sang En 2 Eui Ju Lee 3 Hong, Seok-Cheol 4 Koh Byung-Hee 5 Cho Whang Sung 2

1한국한의학연구원
2
3경희대학교
4경희대학교 한의과대학 사상의학교실
5경희대학교 한의과대학 사상체질과

ABSTRACT

Amp-FLP is a one of the most frequently used human genetic analysis methods which adopts STR and VNTR typings. In this study, 100 genomic DNA samples of Taeum, Soyang and Soum constitution group were analysed by Amp-FLP method. The allele distribution of three STR loci(TH01, vWA and CSF1PO) and one VNTR locus(MCT118) of each different constitution group were investigated and the allele distribution was statistically evaluated. It was found out that the allele distribution of MCT118 and THO1 loci was not significantly different among different constitutions. However, the allele distribution of vWA showed p-value of 0.02056(Soyang group) and 2.41 × 10 − 10 (Soum group) which is much lower than significant level of p-value 0.05. Also, p-value of CSF1PO in Soum group was found out to be 4.65 × 10 − 17 . Therefore, it is expected that vWA and CSF1PO loci can be used as an indicator for gnenetic difference of different constiturion if the same result is obtained with sufficient number of samples.

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