Exploring the Mechanisms and Target Diseases of Sasang Constitutional Prescription based on Multiscale Interactome (다계층 상호작용 네트워크 기반 사상처방의 작용 기전과 대상 질환 탐색 연구)

Won-Yung Lee (이원융); Kim Ji Hwan (김지환)

Exploring the Mechanisms and Target Diseases of Sasang Constitutional Prescription based on Multiscale Interactome

Journal of Sasang Constitutional Medicine
Abbr : J Sasang Constitut Med
2023, 35(4), pp.10-22
Publisher : The Society Of Sasang Constitutional Medicine
Research Area : Medicine and Pharmacy > Korean Medicine
Received : November 20, 2023
Accepted : December 14, 2023
Published : December 31, 2023

Won-Yung Lee ¹, Kim Ji Hwan ²

¹원광대학교 한의과대학 병리학교실 교수
²가천대학교 한의과대학 사상체질의학교실 교수

Accredited

ABSTRACT

Objectives The aim of this study is to explore the mechanism of action and target diseases of Sasang constitutional prescriptions using a multiscale interactome approach. Methods The compound and target information of Sasang constitutional prescriptions were retrieved from various databases such as the TM-MC, STITCH, and TTD. Key targets for Sasang constitutional prescriptions were identified by selecting the top 100 targets based on the number of simple paths within the constructed network. Diffusion profiles for Sasang constitutional prescriptions and diseases were calculated based on a biased random walk algorithm. Potential diseases and key mechanisms of Sasang constitutional prescriptions were identified by analyzing diffusion profiles. Results We identified 144 Sasang constitutional prescriptions and their targets, finding 80 herbs with effective biological targets. A cluster analysis based on selecting up to 100 key targets for each prescription revealed a more cohesive grouping of prescriptions according to Sasang constitution. We then predicted potential diseases for 62 Sasang constitutional prescriptions using diffusion profiles calculated on a multiscale interactome. Finally, our analysis of diffusion profiles revealed key targets and biological functions of prescriptions in obesity and diabetes. Conclusions This study demonstrates the effectiveness of a multiscale interactome approach in elucidating the complex mechanisms and potential therapeutic applications of prescriptions in Sasang constitutional medicine.

KEYWORDS

Sasang constitutional medicine, Herbal medicine, Network pharmacology, Multiscale interactome, Disease, Mechanism

Citation status

* References for papers published after 2023 are currently being built.

[journal] 이진욱 / 2013 / The Effect of Yongyukjowitang Distillate on the Immune Activity of Spleen Cells of Aged Rats / 사상체질의학회지 / 사상체질의학회 25(3) : 218~232

[journal] 곽진영 / 2017 / The Effect of Phaseolus Angularis Shell on Soyang-in Metabolic Syndrome with Obesity / 사상체질의학회지 / 사상체질의학회 29(2) : 136~153

[journal] Kim HG / 2020 / Analysis of Research Trends in Papers Published in the Journal of Sasang Constitutional Medicine from 1989 to 2018 / J Sasang Constit Med 32(1) : 1~11

[journal] Hopkins AL / 2008 / Network pharmacology : the next paradigm in drug discovery / Nat Chem Biol 4(11) : 682~690

[journal] Barabási AL / 2011 / Network medicine : a network-based approach to human disease / Nat Rev Genet 12(1) : 56~68

[journal] Zhang W / 2019 / Systems pharmacology for investigation of the mechanisms of action of traditional Chinese medicine in drug discovery / Front Pharmacol 10 : 743~

[journal] Wan Y / 2019 / Utilising network pharmacology to explore the underlying mechanism of Wumei Pill in treating pancreatic neoplasms / BMC Complement Altern Med 19 : 1~12

[journal] Pang HQ / 2018 / Integrated metabolomics and network pharmacology approach to explain possible action mechanisms of Xin-Sheng-Hua granule for treating anemia / Front Pharmacol 9 : 165~

[journal] Ruiz C / 2021 / Identification of disease treatment mechanisms through the multiscale interactome / Nat Commun 12(1) : 1796~

[journal] 김지환 / 2019 / The study on the selection of Sasang Constitution-specific herbs in 『Dongyisusebowon Sinchuk-Bon』 from TCMID and TCMSP / 사상체질의학회지 / 사상체질의학회 31(3) : 19~33

[journal] 배효상 / 2002 / The study on the formative process of Soeumin prescription / 사상체질의학회지 / 사상체질의학회 14(1) : 10~25

[journal] 배효상 / 2001 / The study on history of prescription through comparison Dongyi-Soose-Bowon Chopanbon with Sasang-Yihak-Chobonguen and Dongyi-Soose-Bowon Gapobon / 사상체질의학회지 / 사상체질의학회 13(2) : 110~123

[journal] 배효상 / 2002 / The study on the formative process of Soyangin prescription / 사상체질의학회지 / 사상체질의학회 14(3) : 33~51

[journal] 김종열 / 2002 / A Research on the Classification of Herbal Medicines based on the Sasang Constitution (Taeumin and Taeyangin Part) / 사상체질의학회지 / 사상체질의학회 14(1) : 1~9

[journal] Kim SK / 2015 / TM-MC : a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine / BMC Complement Altern Med 15(1) : 1~8

[journal] Huang Y / 2019 / A systems pharmacology approach uncovers wogonoside as an angiogenesis inhibitor of triple-negative breast cancer by targeting hedgehog signaling / Cell Chem Biol 26(8) : 1143~1158

[journal] Szklarczyk D / 2016 / STITCH 5 : augmenting protein-chemical interaction networks with tissue and affinity data / Nucleic Acids Res 44(D1) : D380~

[journal] Wang Y / 2020 / Therapeutic target database 2020 : enriched resource for facilitating research and early development of targeted therapeutics / Nucleic Acids Res 48(D1) : D1031~

[journal] Zhang Y / 2015 / Uncovering pharmacological mechanisms of Wu-tou decoction acting on rheumatoid arthritis through systems approaches : drug-target prediction, network analysis and experimental validation / Sci Rep 5(1) : 9463~

[journal] Wang X / 2020 / Network pharmacology to uncover the biological basis of spleen qi deficiency syndrome and herbal treatment / Oxid Med Cell Longev 2020 : 1~20

[journal] Oughtred, R. / 2019 / The BioGRID interaction database : 2019 update / Nucleic Acids Res 47 : D529~D541

[journal] Salwinski, L. / 2004 / The Database of Interacting Proteins : 2004 update / Nucleic Acids Res 32 : D449~D451

[journal] Rolland T / 2014 / A proteome-scale map of the human interactome network / Cell 159(5) : 1212~1226

[journal] Piñero J / 2020 / The DisGe-NET knowledge platform for disease genomics : 2019 update / Nucleic Acids Res 48(D1) : D845~D55

[journal] Hu S / 2022 / A tensor-based bi-random walks model for protein function prediction / BMC Bioinformatics 23(1) : 1~19

[journal] Nakajima K / 2023 / Random walk sampling in social networks involving private nodes / ACM Trans Knowl Discov Data 17(4) : 1~28

[other] Dvurechensky P / 2014 / Random walk based web page ranking functions learning with gradient-free optimization methods / arXiv

[book] Society of Sasang constitutional medicine / 2022 / Clinical Practice Guideline of Korean Medicine Sasang Constitutional Medicine Patterns / PanMun Education : 11~12

[journal] Matias I / 2007 / Endocannabinoids and the control of energy balance / Trends Endocrinol Metab 18(1) : 27~37

[journal] Schioth HB / 2006 / G protein-coupled receptors in regulation of body weight / CNS Neurol Disord Drug Targets 5(3) : 241~249

[journal] Strycharz J / 2017 / Is p53 involved in tissue-specific insulin resistance formation? / Oxid Med Cell Longev : 9270549~

[journal] Mendes NF / 2018 / TGF-β1 down-regulation in the mediobasal hypothalamus attenuates hypothalamic inflammation and protects against diet-induced obesity / Metabolism 85 : 171~182

[journal] Genua M / 2009 / c Abl and Insulin Receptor Signalling / Vitam Horm 80 : 77~105

[journal] Lawrence T / 2009 / The nuclear factor NF-κB pathway in inflammation / Cold Spring Harb Perspect Biol 1(6) : a001651~

[journal] Kyriakis JM / 2012 / Mammalian MAPK signal transduction pathways activated by stress and inflammation : a 10-year update / Physiol Rev 92(2) : 689~737

This paper was written with support from the National Research Foundation of Korea.

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