@article{ART000871336},
author={김현진 and Kim Ok Joon and Hwang Yun Chan and 신주호 and 박하옥 and Kim Min Seok and LEE EUN JOO and Sun-Hun Kim},
title={Effects of Cyclosporin A on the Epiphyseal Plate Growth in Rats},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2003},
volume={16},
number={3},
pages={177-188},
doi={10.11637/aba.2003.16.3.177}
TY - JOUR
AU - 김현진
AU - Kim Ok Joon
AU - Hwang Yun Chan
AU - 신주호
AU - 박하옥
AU - Kim Min Seok
AU - LEE EUN JOO
AU - Sun-Hun Kim
TI - Effects of Cyclosporin A on the Epiphyseal Plate Growth in Rats
JO - Anatomy & Biological Anthropology
PY - 2003
VL - 16
IS - 3
PB - 대한체질인류학회
SP - 177
EP - 188
SN - 2671-5651
AB - Effects of Cyclosporin A on the Epiphyseal Plate Growth in Rats HJ Kim, OJ Kim, YC Hoang, JH Shin, HO Park, MS Kim, EJ Lee, SH KimDental Science Research Institute, College of DentistryCyclosporin A (CsA), hydrophobic cyclic peptide composed of 11 amino acids has been currently used in immuno-suppression by its ability to inhibit cytokine release. The inhibition of cytokine release can secondarily affect on bonemetabolism, modelling and remodelling. Current concept suggests that CsA can induce osteopenia by stimulating bothbone formation and resorption. But many reports have not been coincident each other in respect of its action mechanismin vivo and in vitro. The present study was performed to clarify CsA effects on bone growth using cell proliferation assay, gene expres-sion in vitro using MC3T3 cell line. Histomorphomertical data were obtained from knee joint in vivo after 3, 7 and 14days of each CsA treatment. MC3T3-E1 cell proliferation was inhibited by the treatment of CsA 1,000 ng/ml and 1,500 ng/ml in concentrationfor 1 and 3 days. CollagenI(α)1 gene expression was decreased by the treatment in a dose dependant manner, whereasALP expression was stable in every concentration of treatment. Histomorphometrical data analysis such as length ofhypertrophied and proliferating cartilage layer, area of secondary ossification center, trabecular bone length underneaththe epiphyseal plate and finally chondroclast number and size showed that most of the measurements were decreased
KW -
DO - 10.11637/aba.2003.16.3.177
ER -
김현진, Kim Ok Joon, Hwang Yun Chan, 신주호, 박하옥, Kim Min Seok, LEE EUN JOO and Sun-Hun Kim. (2003). Effects of Cyclosporin A on the Epiphyseal Plate Growth in Rats. Anatomy & Biological Anthropology, 16(3), 177-188.
김현진, Kim Ok Joon, Hwang Yun Chan, 신주호, 박하옥, Kim Min Seok, LEE EUN JOO and Sun-Hun Kim. 2003, "Effects of Cyclosporin A on the Epiphyseal Plate Growth in Rats", Anatomy & Biological Anthropology, vol.16, no.3 pp.177-188. Available from: doi:10.11637/aba.2003.16.3.177
김현진, Kim Ok Joon, Hwang Yun Chan, 신주호, 박하옥, Kim Min Seok, LEE EUN JOO, Sun-Hun Kim "Effects of Cyclosporin A on the Epiphyseal Plate Growth in Rats" Anatomy & Biological Anthropology 16.3 pp.177-188 (2003) : 177.
김현진, Kim Ok Joon, Hwang Yun Chan, 신주호, 박하옥, Kim Min Seok, LEE EUN JOO, Sun-Hun Kim. Effects of Cyclosporin A on the Epiphyseal Plate Growth in Rats. 2003; 16(3), 177-188. Available from: doi:10.11637/aba.2003.16.3.177
김현진, Kim Ok Joon, Hwang Yun Chan, 신주호, 박하옥, Kim Min Seok, LEE EUN JOO and Sun-Hun Kim. "Effects of Cyclosporin A on the Epiphyseal Plate Growth in Rats" Anatomy & Biological Anthropology 16, no.3 (2003) : 177-188.doi: 10.11637/aba.2003.16.3.177
김현진; Kim Ok Joon; Hwang Yun Chan; 신주호; 박하옥; Kim Min Seok; LEE EUN JOO; Sun-Hun Kim. Effects of Cyclosporin A on the Epiphyseal Plate Growth in Rats. Anatomy & Biological Anthropology, 16(3), 177-188. doi: 10.11637/aba.2003.16.3.177
김현진; Kim Ok Joon; Hwang Yun Chan; 신주호; 박하옥; Kim Min Seok; LEE EUN JOO; Sun-Hun Kim. Effects of Cyclosporin A on the Epiphyseal Plate Growth in Rats. Anatomy & Biological Anthropology. 2003; 16(3) 177-188. doi: 10.11637/aba.2003.16.3.177
김현진, Kim Ok Joon, Hwang Yun Chan, 신주호, 박하옥, Kim Min Seok, LEE EUN JOO, Sun-Hun Kim. Effects of Cyclosporin A on the Epiphyseal Plate Growth in Rats. 2003; 16(3), 177-188. Available from: doi:10.11637/aba.2003.16.3.177
김현진, Kim Ok Joon, Hwang Yun Chan, 신주호, 박하옥, Kim Min Seok, LEE EUN JOO and Sun-Hun Kim. "Effects of Cyclosporin A on the Epiphyseal Plate Growth in Rats" Anatomy & Biological Anthropology 16, no.3 (2003) : 177-188.doi: 10.11637/aba.2003.16.3.177
