@article{ART001143447},
author={오세옥 and 김봉선 and Jaebong Kim and Yongsuk Moon and BAE,SOO-KYUNG and 윤식 and 백선용},
title={Expression of BMP antagonists in Shh-/-: Gli3-/- mutant},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2005},
volume={18},
number={1},
pages={57-68},
doi={10.11637/aba.2005.18.1.57}
TY - JOUR
AU - 오세옥
AU - 김봉선
AU - Jaebong Kim
AU - Yongsuk Moon
AU - BAE,SOO-KYUNG
AU - 윤식
AU - 백선용
TI - Expression of BMP antagonists in Shh-/-: Gli3-/- mutant
JO - Anatomy & Biological Anthropology
PY - 2005
VL - 18
IS - 1
PB - 대한체질인류학회
SP - 57
EP - 68
SN - 2671-5651
AB - Sonic hedgehog (Shh) has been known as an essential morphogen for the generation of motor neuron in developing
spinal cord. However, motor neuron can be generated in Shh-/-; Gli3-/- or Gli2-/-; Gli3-/- mutants although these mutants
don’t have Shh signaling. To find out the compensatory mechanism for the generation of motor neuron in Shh-/-;
Gli3-/- mutant, we studied bone morphogenetic protein (BMP) antagonists including follistatin, flik and noggin, and
retinoic acid signaling in this mutant.
To study expressions of BMP antagonists, we performed in situ hybridization. To examine an activity of retinoic
acid, we measured β-galactosidase activity in retinoic acid response element (RARE) transgenic mouse.
The expression of follistatin was reduced at both levels of forelimb and hindlimb in Shh-/- mutant compared to wild
type embryo. It was restored at the level of forelimb but reduced at the level of hindlimb in Shh-/-; Gli3-/- mutant
compared to wild type. The expression of flik was similar with wild type embryo at both levels of forelimb and
hindlimb in Shh-/- mutant. The expression of flik was similar with wild type embryo at the level of forelimb however
reduced in hindlimb level in Shh-/-; Gli3-/- mutant. The expression of noggin, a BMP antagonist, was increased in Shh-/-
mutant. Activity of retinoic acid signaling was not affected in Shh-/- or Shh-/-; Gli3-/- mutants.
From these results, we conclude that retinoic acid but not follistatin and flik, may be involved in the generation of
motor neuron in Shh-/-; Gli3-/- mutant.
KW - BMP antagonists;Follistatin;Flik;Noggin;Sonic hedgehog;Retinoic acid
DO - 10.11637/aba.2005.18.1.57
ER -
오세옥, 김봉선, Jaebong Kim, Yongsuk Moon, BAE,SOO-KYUNG, 윤식 and 백선용. (2005). Expression of BMP antagonists in Shh-/-: Gli3-/- mutant. Anatomy & Biological Anthropology, 18(1), 57-68.
오세옥, 김봉선, Jaebong Kim, Yongsuk Moon, BAE,SOO-KYUNG, 윤식 and 백선용. 2005, "Expression of BMP antagonists in Shh-/-: Gli3-/- mutant", Anatomy & Biological Anthropology, vol.18, no.1 pp.57-68. Available from: doi:10.11637/aba.2005.18.1.57
오세옥, 김봉선, Jaebong Kim, Yongsuk Moon, BAE,SOO-KYUNG, 윤식, 백선용 "Expression of BMP antagonists in Shh-/-: Gli3-/- mutant" Anatomy & Biological Anthropology 18.1 pp.57-68 (2005) : 57.
오세옥, 김봉선, Jaebong Kim, Yongsuk Moon, BAE,SOO-KYUNG, 윤식, 백선용. Expression of BMP antagonists in Shh-/-: Gli3-/- mutant. 2005; 18(1), 57-68. Available from: doi:10.11637/aba.2005.18.1.57
오세옥, 김봉선, Jaebong Kim, Yongsuk Moon, BAE,SOO-KYUNG, 윤식 and 백선용. "Expression of BMP antagonists in Shh-/-: Gli3-/- mutant" Anatomy & Biological Anthropology 18, no.1 (2005) : 57-68.doi: 10.11637/aba.2005.18.1.57
오세옥; 김봉선; Jaebong Kim; Yongsuk Moon; BAE,SOO-KYUNG; 윤식; 백선용. Expression of BMP antagonists in Shh-/-: Gli3-/- mutant. Anatomy & Biological Anthropology, 18(1), 57-68. doi: 10.11637/aba.2005.18.1.57
오세옥; 김봉선; Jaebong Kim; Yongsuk Moon; BAE,SOO-KYUNG; 윤식; 백선용. Expression of BMP antagonists in Shh-/-: Gli3-/- mutant. Anatomy & Biological Anthropology. 2005; 18(1) 57-68. doi: 10.11637/aba.2005.18.1.57
오세옥, 김봉선, Jaebong Kim, Yongsuk Moon, BAE,SOO-KYUNG, 윤식, 백선용. Expression of BMP antagonists in Shh-/-: Gli3-/- mutant. 2005; 18(1), 57-68. Available from: doi:10.11637/aba.2005.18.1.57
오세옥, 김봉선, Jaebong Kim, Yongsuk Moon, BAE,SOO-KYUNG, 윤식 and 백선용. "Expression of BMP antagonists in Shh-/-: Gli3-/- mutant" Anatomy & Biological Anthropology 18, no.1 (2005) : 57-68.doi: 10.11637/aba.2005.18.1.57
