@article{ART001143689},
author={정제오 and Soon-Jeong Jeong and 박주철 and Kim, Heung Joong and Wahl SM and Jeong Moon-Jin},
title={Morphological Differences of the Wound Healing inSecretory Leukocyte Protease Inhibitor Knockout Mice},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2005},
volume={18},
number={3},
pages={197-206},
doi={10.11637/aba.2005.18.3.197}
TY - JOUR
AU - 정제오
AU - Soon-Jeong Jeong
AU - 박주철
AU - Kim, Heung Joong
AU - Wahl SM
AU - Jeong Moon-Jin
TI - Morphological Differences of the Wound Healing inSecretory Leukocyte Protease Inhibitor Knockout Mice
JO - Anatomy & Biological Anthropology
PY - 2005
VL - 18
IS - 3
PB - 대한체질인류학회
SP - 197
EP - 206
SN - 2671-5651
AB - Secretory leukocyte protease inhibitor (SLPI) is a serine protease inhibitor with anti-microbial properties found in mucosal fluids. At the tissue level, the ability of this 12kDa protein is to counteract the excessive degradation of functional and structural proteins such as collagen and fibronectin. Impaired healing states are characterized by excessive proteolysis and often bacterial infection, leading to the hypothesis that SLPI may have a role in this process. To investigate the role of SLPI in skin how it contributes to tissue repair, we have generated mice null for the gene encoding SLPI (Slpi), which show impaired cutaneous wound healing with increased inflammation. For the purpose of this, we have performed wound experiment in skin tissue with morphometrical analyses, immunohistochemistry, and Rnase protection assay. From these analyses, the results were that delayed healing in KO mice wounds compared to that of WT, prolonged
inflammatory phase and increased TGF-β1 in KO wounds, and lower mechanical properties in KO wounds. Taken together, SLPI may play a cruical role in cutaneous wounds healing especially in matrix reorganization that suggests the development as a clinical drug for wound healing.
KW - Wound healing;Secretory leukocyte protease inhibitor (SLPI);Epithelial tissue;Matrix formation;
DO - 10.11637/aba.2005.18.3.197
ER -
정제오, Soon-Jeong Jeong, 박주철, Kim, Heung Joong, Wahl SM and Jeong Moon-Jin. (2005). Morphological Differences of the Wound Healing inSecretory Leukocyte Protease Inhibitor Knockout Mice. Anatomy & Biological Anthropology, 18(3), 197-206.
정제오, Soon-Jeong Jeong, 박주철, Kim, Heung Joong, Wahl SM and Jeong Moon-Jin. 2005, "Morphological Differences of the Wound Healing inSecretory Leukocyte Protease Inhibitor Knockout Mice", Anatomy & Biological Anthropology, vol.18, no.3 pp.197-206. Available from: doi:10.11637/aba.2005.18.3.197
정제오, Soon-Jeong Jeong, 박주철, Kim, Heung Joong, Wahl SM, Jeong Moon-Jin "Morphological Differences of the Wound Healing inSecretory Leukocyte Protease Inhibitor Knockout Mice" Anatomy & Biological Anthropology 18.3 pp.197-206 (2005) : 197.
정제오, Soon-Jeong Jeong, 박주철, Kim, Heung Joong, Wahl SM, Jeong Moon-Jin. Morphological Differences of the Wound Healing inSecretory Leukocyte Protease Inhibitor Knockout Mice. 2005; 18(3), 197-206. Available from: doi:10.11637/aba.2005.18.3.197
정제오, Soon-Jeong Jeong, 박주철, Kim, Heung Joong, Wahl SM and Jeong Moon-Jin. "Morphological Differences of the Wound Healing inSecretory Leukocyte Protease Inhibitor Knockout Mice" Anatomy & Biological Anthropology 18, no.3 (2005) : 197-206.doi: 10.11637/aba.2005.18.3.197
정제오; Soon-Jeong Jeong; 박주철; Kim, Heung Joong; Wahl SM; Jeong Moon-Jin. Morphological Differences of the Wound Healing inSecretory Leukocyte Protease Inhibitor Knockout Mice. Anatomy & Biological Anthropology, 18(3), 197-206. doi: 10.11637/aba.2005.18.3.197
정제오; Soon-Jeong Jeong; 박주철; Kim, Heung Joong; Wahl SM; Jeong Moon-Jin. Morphological Differences of the Wound Healing inSecretory Leukocyte Protease Inhibitor Knockout Mice. Anatomy & Biological Anthropology. 2005; 18(3) 197-206. doi: 10.11637/aba.2005.18.3.197
정제오, Soon-Jeong Jeong, 박주철, Kim, Heung Joong, Wahl SM, Jeong Moon-Jin. Morphological Differences of the Wound Healing inSecretory Leukocyte Protease Inhibitor Knockout Mice. 2005; 18(3), 197-206. Available from: doi:10.11637/aba.2005.18.3.197
정제오, Soon-Jeong Jeong, 박주철, Kim, Heung Joong, Wahl SM and Jeong Moon-Jin. "Morphological Differences of the Wound Healing inSecretory Leukocyte Protease Inhibitor Knockout Mice" Anatomy & Biological Anthropology 18, no.3 (2005) : 197-206.doi: 10.11637/aba.2005.18.3.197
