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@article{ART001211492},
author={박주철 and 신인철 and 이동설 and 윤성호 and 양재호 and 김상봉 and 김흥중},
title={Effects of Melatonin on MDPC-23 Cells Differentiation},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2007},
volume={20},
number={2},
pages={105-113},
doi={10.11637/aba.2007.20.2.105}

TY - JOUR
AU - 박주철
AU - 신인철
AU - 이동설
AU - 윤성호
AU - 양재호
AU - 김상봉
AU - 김흥중
TI - Effects of Melatonin on MDPC-23 Cells Differentiation
JO - Anatomy & Biological Anthropology
PY - 2007
VL - 20
IS - 2
PB - 대한체질인류학회
SP - 105
EP - 113
SN - 2671-5651
AB - Melatonin is the major hormone released from the pineal gland and regulates a variety of physiological and pathophysiological processes. According to the recent studies the melatonin plays an important role in regulation of bone growth. The purpose of this study was to determine whether melatonin promotes the cell differentiation and nodules formation in MDPC-23 pre-odontoblast cell line. MDPC-23 cells were cultured for up to 15 days in growth media containing differentiation medium with melatonin or without melatonin. Cultures were stained with Alizarin-S. The expression of the mRNAs for DSPP, OC, ALP and NFI-C were analyzed by RT-PCR. The results were as follows. Cultures containing melatonin at day 15 showed extensive mineralization as compared with control cultures. Melatonin increased the expression of DSPP and OC mRNAs in MDPC-23 cells in a concentration- dependent manner. However, melatonin did not changed ALP expression. Melatonin markedly decreased mRNA expression of NFI-C in early stage cultures as compared with control cultures. These results demonstrated that melatonin is capable of promoting MDPC-23 cells differentiation and mineralization and suggested that melatonin may play an important role in dentin formation.
KW - Melatonin;MDPC-23;Differentiation;Mineralization
DO - 10.11637/aba.2007.20.2.105
ER -

박주철, 신인철, 이동설, 윤성호, 양재호, 김상봉 and 김흥중. (2007). Effects of Melatonin on MDPC-23 Cells Differentiation. Anatomy & Biological Anthropology, 20(2), 105-113.

박주철, 신인철, 이동설, 윤성호, 양재호, 김상봉 and 김흥중. 2007, "Effects of Melatonin on MDPC-23 Cells Differentiation", Anatomy & Biological Anthropology, vol.20, no.2 pp.105-113. Available from: doi:10.11637/aba.2007.20.2.105

박주철, 신인철, 이동설, 윤성호, 양재호, 김상봉, 김흥중 "Effects of Melatonin on MDPC-23 Cells Differentiation" Anatomy & Biological Anthropology 20.2 pp.105-113 (2007) : 105.

박주철, 신인철, 이동설, 윤성호, 양재호, 김상봉, 김흥중. Effects of Melatonin on MDPC-23 Cells Differentiation. 2007; 20(2), 105-113. Available from: doi:10.11637/aba.2007.20.2.105

박주철, 신인철, 이동설, 윤성호, 양재호, 김상봉 and 김흥중. "Effects of Melatonin on MDPC-23 Cells Differentiation" Anatomy & Biological Anthropology 20, no.2 (2007) : 105-113.doi: 10.11637/aba.2007.20.2.105

박주철; 신인철; 이동설; 윤성호; 양재호; 김상봉; 김흥중. Effects of Melatonin on MDPC-23 Cells Differentiation. Anatomy & Biological Anthropology, 20(2), 105-113. doi: 10.11637/aba.2007.20.2.105

박주철; 신인철; 이동설; 윤성호; 양재호; 김상봉; 김흥중. Effects of Melatonin on MDPC-23 Cells Differentiation. Anatomy & Biological Anthropology. 2007; 20(2) 105-113. doi: 10.11637/aba.2007.20.2.105

박주철, 신인철, 이동설, 윤성호, 양재호, 김상봉, 김흥중. Effects of Melatonin on MDPC-23 Cells Differentiation. 2007; 20(2), 105-113. Available from: doi:10.11637/aba.2007.20.2.105

박주철, 신인철, 이동설, 윤성호, 양재호, 김상봉 and 김흥중. "Effects of Melatonin on MDPC-23 Cells Differentiation" Anatomy & Biological Anthropology 20, no.2 (2007) : 105-113.doi: 10.11637/aba.2007.20.2.105