Effects of Prenatal Stress and Restraint Stress on Amygdala Complex of the Rat: II. Effects on the Astrocytic Cell Processes (출생 전 스트레스와 감금 스트레스가 편도복합체에 미치는 영향: II. 별아교세포의 세포질돌기에 미치는 영향)

이진숙; Byung Young Choi (최병영); 조병필; LEE Ji Yong (이지용); 정원석; 양영철

doi:10.11637/aba.2008.21.3.235

Effects of Prenatal Stress and Restraint Stress on Amygdala Complex of the Rat: II. Effects on the Astrocytic Cell Processes

Anatomy & Biological Anthropology
Abbr : Anat Biol Anthropol
2008, 21(3), pp.235~243
DOI : 10.11637/aba.2008.21.3.235
Publisher : 대한체질인류학회
Research Area : Medicine and Pharmacy > Anatomy

이진숙 ¹, Byung Young Choi ¹, 조병필 ², LEE Ji Yong ¹, 정원석 ¹, 양영철 ²

¹연세대학교 원주의과대학 해부학교실
²연세대학교

Accredited

ABSTRACT

The hypothesis that adverse experience alters the balance of neurotransmitters in the amygdala rendering it hyperresponsive to stress was examined in the present study. Since astrocytes regulate the brain’s neurochemical milieu by uptaking neurotransmitters, we have examined these cells in the amygdala of prenatally stressed rats, a model of pathological anxiety. Here we examined morphometric changes on the cell bodies of astrocytes in the amygdala induced by prenatal stress and restraint stress. For this purpose, rats were classified into 4 groups; control group (CON), only restraint stressed (starting on P90 for 3 days) group (CONR), prenatally stressed group (PNS), and prenatally and restraint (on P90 for 3 days) stressed group (PNSR). Astrocytes stained with GFAP immunohistochemistry were counter stained with methylene blue/azure II and were examined using the Neurolucida. The present study showed that prenatal and restraint stress caused the significant increase in the total number and length of the amygdaloid astrocytic processes. In conclusion, astrocytes show structural indices of activation with stress.

KEYWORDS

Prenatal stress, Restraint stress, Amygdala complex, Astrocyte

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Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Effects of Prenatal Stress and Restraint Stress on Amygdala Complex of the Rat: II. Effects on the Astrocytic Cell Processes

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* References for papers published after 2023 are currently being built.

Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Effects of Prenatal Stress and Restraint Stress on Amygdala Complex of the Rat: II. Effects on the Astrocytic Cell Processes

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