Effects of Liriopis Tuber Water Extract on RANKL-induced Osteoclast Differentiation (RANKL에 의해 유도되는 뼈파괴세포 분화에 맥문동의 효과)

박기인; 오재민

doi:10.11637/aba.2011.24.4.237

Effects of Liriopis Tuber Water Extract on RANKL-induced Osteoclast Differentiation

Anatomy & Biological Anthropology
Abbr : Anat Biol Anthropol
2011, 24(4), pp.237~244
DOI : 10.11637/aba.2011.24.4.237
Publisher : 대한체질인류학회
Research Area : Medicine and Pharmacy > Anatomy

박기인 ¹, 오재민 ²

¹전북대학교
²원광대학교

Accredited

ABSTRACT

Increased formation and activation of osteoclast lead to unwanted bone resorption. Several natural products which have inhibitory effects on osteoclast differentiation and function are under investigation to prevent and treat the osteoporotic bone disease. Liriopis tuber has been used in Oriental medicine for the suppression of cough, expectoration, thirst, and has been used for sthenia, diuresis, blood glucose regulation, treatment of xerostomia,and constipation. Also, recently it has been reported that Liriopsis tuber has anti-inflammatory, anti-thrombic,anti-adhesive activities. The purpose of this study was to evaluate the effects of Liriopis tuber on osteoclast differentiation and was to evaluate of its mechanism. Water extract of Liriopis tuber significantly inhibited receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation in bone marrow macrophages (BMMs) in a dose dependent manner. However, water extract of Liriopis tuber did not affect cytotoxicity when compared with control. The mRNA expression of c-Fos, NFATc1, tartrate resistant-acid phosphatase (TRAP), and cathepsin K induced by RANKL was inhibited by water extract of Liriopis tuber treatment. Also, water extract of Liriopis tuber inhibited the protein expression of c-Fos and NFATc1 expression in BMMs treated with RANKL. Among the signal pathways, water extract of Liriopis tuber suppressed the phosphorylation of p38 induced by RANKL. In summary, Liriopis tuber exerted inhibitory effects on osteoclast diffentiation via suppression of c-Fos and NFATc1 which are essential gene to osteoclastogenesis. Taken together, these results suggest that Liriopis tuber may be a useful candidate in the treatment of osteoporosis without special toxicity.

KEYWORDS

Liriopis tuber, Bone, RANKL, Osteoclast

Citation status

* References for papers published after 2023 are currently being built.

[journal] Böhm C / 2009 / alphaisoform of p38 MAPK specifically regulates arthritic bone loss / J Immunol 183 : 5938~5947

[journal] Boyle WJ / 2003 / Osteoclast differentiation and activation / Nature 423 : 337~342

[journal] 최윤홍 / 2010 / Effects of Gastrodia elata Blune Water Extract on RANKL-induced Osteoclast Differentiation / 동의생리병리학회지 / 대한동의병리학회 24(5) : 807~813

[book] Chung B / 1998 / Ilustrated Dictionary of Folk Medicine / Younglim Company : 177~178

[journal] Galibert L / 1998 / The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-κB, a member of the TNFR superfamily / J Biol Chem 273 : 34120~34127

[journal] Hamoudeh E / 2009 / Evaluation of secondary causes of bone loss in a primary care setting / Endocr Pract 15 : 410~414

[journal] Huang H / 2006 / Induction of c-Fos and NFATc1 during RANKL-stimulated osteoclast differentiation is mediated by the p38 signaling pathway / Biochem Biophys Res Commun 351 : 99~105

[journal] Kim SJ / 2008 / Extracts of Liriopsis Tuber protect AMPA induced brain damage and improve memory with the activation of insulin receptor and ERK I/II / Phytother Res 22 : 1450~1457

[journal] Kou J / 2005 / Antiinflammatory activities of aqueous extract from Radix Ophiopogon japonicus and its two constituents / Biol Pharm Bull 28 : 1234~1238

[journal] Kou J / 2005 / effects of ethanol extract from Radix phiopogon japonicus on venous thrombosis linked with endothelium-protective and anti-adhesive activites / Vasc Pharmacol 43 : 157~163

[journal] Kou J / 2006 / Antithrombic activities of aqueous extract from Radix Ophiopogon japonicus and its two constituents / Biol Pharm Bull 29 : 1267~1270

[journal] 리연 / 2010 / Effect of Water Extract of Schisandra Chinensis on Osteoclast Differentiation / 동의생리병리학회지 / 대한동의병리학회 24(5) : 848~853

[journal] Maricic M / 2011 / Update on glucocorticoid-induced osteoporosis / Rheum Dis Clin North Am 37 : 415~431

[journal] McClung M / 2011 / Effect of denosumab treatment on the risk of fractures in subgroups of women with postmenopausal osteoporosis / Bone Miner Res

[journal] Melton LJ 3rd / 2005 / Potential impact of osteoporosis treatment on hip fracture trends / J Bone Miner Res 20 : 895~897

[journal] Nieves JW / 2010 / Atypical subtrochanteric and femoral shaft fractures and possible association with bisphosphonates / Curr Osteoporos Rep 8 : 34~39

[journal] Roux S / 2010 / New treatment targets in osteoporosis / Joint Bone Spine 77(3) : 222~228

[journal] Takayanagi H / 2002 / Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts / Dev Cell 3 : 889~901

[journal] Tanaka S / 2006 / Molecular mechanism of the life and death of the osteoclast / Ann N Y Acad Sci 1068 : 180~186

[journal] Teitelbaum SL / 2003 / Genetic regulation of osteoclast development and function / Nat Rev Genet 4 : 638~649

KJCKorea
Journal Central

Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Effects of Liriopis Tuber Water Extract on RANKL-induced Osteoclast Differentiation

ABSTRACT

KEYWORDS

Citation status

* References for papers published after 2023 are currently being built.

Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Effects of Liriopis Tuber Water Extract on RANKL-induced Osteoclast Differentiation

ABSTRACT

KEYWORDS

Statistics

Tools

Issue List

Citation status

KCI Citation Counts (2)

REFERENCES (20) * References for papers published after 2023 are currently being built.

Search PDF

Citation

* References for papers published after 2023 are currently being built.