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@article{ART002119335},
author={Lee, Chung Eun},
title={Kainic Acid Treatment Increases Ca2+-mediated Neurotoxicity in the Mouse Hippocampus},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2016},
volume={29},
number={2},
pages={71-79},
doi={10.11637/aba.2016.29.2.71}

TY - JOUR
AU - Lee, Chung Eun
TI - Kainic Acid Treatment Increases Ca2+-mediated Neurotoxicity in the Mouse Hippocampus
JO - Anatomy & Biological Anthropology
PY - 2016
VL - 29
IS - 2
PB - 대한체질인류학회
SP - 71
EP - 79
SN - 2671-5651
AB - Kainic acid (KA)-induced neuronal cell death is associated with intracellular Ca2+ influx. However, it is unknown whether Lyn/Btk pathway is involved in the Ca2+-mediated neurotoxicity and neuronal death induced by KA. In the present study, we investigated the altered expression of Ca2+-controlled proteins in KA-treated hippocampus. Mice were sacrificed at 24 h after KA (20 mg/kg) systemic injection. We conducted Electroencephalographic (EEG) recording and examined hippocampal alterations by Western blotting and immunostaining in control mice or KA-treated mice. EEG tests showed that KA-treated mice increased seizure frequency and severity compared with control mice during KA-induced seizures. We found that KA decreases hippocalcin and calpain-mediated proteolysis in the hippocampus. In particular, the phosphorylation of Lyn and Btk was increased in KA-treated hippocampus compared to those of control mice. Our findings identify tyrosine kinases such as Lyn/Btk as a critical regulator of Ca2+-mediated neurotoxicity in KA-induced seizures.
KW - Kainic acid;Calcium;Lyn/Btk;Seizure;Hippocampus
DO - 10.11637/aba.2016.29.2.71
ER -

Lee, Chung Eun. (2016). Kainic Acid Treatment Increases Ca2+-mediated Neurotoxicity in the Mouse Hippocampus. Anatomy & Biological Anthropology, 29(2), 71-79.

Lee, Chung Eun. 2016, "Kainic Acid Treatment Increases Ca2+-mediated Neurotoxicity in the Mouse Hippocampus", Anatomy & Biological Anthropology, vol.29, no.2 pp.71-79. Available from: doi:10.11637/aba.2016.29.2.71

Lee, Chung Eun "Kainic Acid Treatment Increases Ca2+-mediated Neurotoxicity in the Mouse Hippocampus" Anatomy & Biological Anthropology 29.2 pp.71-79 (2016) : 71.

Lee, Chung Eun. Kainic Acid Treatment Increases Ca2+-mediated Neurotoxicity in the Mouse Hippocampus. 2016; 29(2), 71-79. Available from: doi:10.11637/aba.2016.29.2.71

Lee, Chung Eun. "Kainic Acid Treatment Increases Ca2+-mediated Neurotoxicity in the Mouse Hippocampus" Anatomy & Biological Anthropology 29, no.2 (2016) : 71-79.doi: 10.11637/aba.2016.29.2.71

Lee, Chung Eun. Kainic Acid Treatment Increases Ca2+-mediated Neurotoxicity in the Mouse Hippocampus. Anatomy & Biological Anthropology, 29(2), 71-79. doi: 10.11637/aba.2016.29.2.71

Lee, Chung Eun. Kainic Acid Treatment Increases Ca2+-mediated Neurotoxicity in the Mouse Hippocampus. Anatomy & Biological Anthropology. 2016; 29(2) 71-79. doi: 10.11637/aba.2016.29.2.71

Lee, Chung Eun. Kainic Acid Treatment Increases Ca2+-mediated Neurotoxicity in the Mouse Hippocampus. 2016; 29(2), 71-79. Available from: doi:10.11637/aba.2016.29.2.71

Lee, Chung Eun. "Kainic Acid Treatment Increases Ca2+-mediated Neurotoxicity in the Mouse Hippocampus" Anatomy & Biological Anthropology 29, no.2 (2016) : 71-79.doi: 10.11637/aba.2016.29.2.71