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@article{ART002235335},
author={Prashanta Silwal and KeunA Shin and Choi Seulgi and Uk Namgung and 이찬용 and Heo Jun Young and Kyu Lim and Park, Jong-Il and Ki-Hwan Kim and Park, Seung-Kiel},
title={Tryptophan Negatively Regulates IgE-mediated Mast Cell Activation},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2017},
volume={30},
number={2},
pages={53-60},
doi={10.11637/aba.2017.30.2.53}

TY - JOUR
AU - Prashanta Silwal
AU - KeunA Shin
AU - Choi Seulgi
AU - Uk Namgung
AU - 이찬용
AU - Heo Jun Young
AU - Kyu Lim
AU - Park, Jong-Il
AU - Ki-Hwan Kim
AU - Park, Seung-Kiel
TI - Tryptophan Negatively Regulates IgE-mediated Mast Cell Activation
JO - Anatomy & Biological Anthropology
PY - 2017
VL - 30
IS - 2
PB - 대한체질인류학회
SP - 53
EP - 60
SN - 2671-5651
AB - Mast cells are major immune cells in allergy to secrete allergic mediators by a degranulation process and make and secrete inflammatory lipids and cytokines in response to antigen stimulation. An amino acid tryptophan regulates immune functions. Tryptophan ameliorates inflammatory colitis in which mast cells are engaged. However, its effects on mast cells remain to be solved. We investigated the effect of tryptophan on IgE-mediated allergic responses in the mast cells and mice. IgEmediated passive cutaneous anaphylaxis (PCA) in mice were examined. Also IgE-mediated mast cell activation responses such as degranulation of stored granules and secretion of inflammatory lipid LTB4 and cytokines (TNF-α and IL-4) were measured. Intraperitoneal administration of tryptophan suppressed PCA in mice. Also, in the cellular level tryptophan inhibited IgE-mediated mast cell activation such as IgE-mediated degranulation and the production of LTB4. Also, it inhibited production of inflammatory cytokines TNF-α and IL-4. In summary, tryptophan suppressed IgE-mediated allergic activation in vivo and in vitro. Tryptophan supplementation is beneficial for IgE-mediated allergy.
KW - Passive cutaneous anaphylaxis;Mast cell;Degranulation;IgE;Tryptophan
DO - 10.11637/aba.2017.30.2.53
ER -

Prashanta Silwal, KeunA Shin, Choi Seulgi, Uk Namgung, 이찬용, Heo Jun Young, Kyu Lim, Park, Jong-Il, Ki-Hwan Kim and Park, Seung-Kiel. (2017). Tryptophan Negatively Regulates IgE-mediated Mast Cell Activation. Anatomy & Biological Anthropology, 30(2), 53-60.

Prashanta Silwal, KeunA Shin, Choi Seulgi, Uk Namgung, 이찬용, Heo Jun Young, Kyu Lim, Park, Jong-Il, Ki-Hwan Kim and Park, Seung-Kiel. 2017, "Tryptophan Negatively Regulates IgE-mediated Mast Cell Activation", Anatomy & Biological Anthropology, vol.30, no.2 pp.53-60. Available from: doi:10.11637/aba.2017.30.2.53

Prashanta Silwal, KeunA Shin, Choi Seulgi, Uk Namgung, 이찬용, Heo Jun Young, Kyu Lim, Park, Jong-Il, Ki-Hwan Kim, Park, Seung-Kiel "Tryptophan Negatively Regulates IgE-mediated Mast Cell Activation" Anatomy & Biological Anthropology 30.2 pp.53-60 (2017) : 53.

Prashanta Silwal, KeunA Shin, Choi Seulgi, Uk Namgung, 이찬용, Heo Jun Young, Kyu Lim, Park, Jong-Il, Ki-Hwan Kim, Park, Seung-Kiel. Tryptophan Negatively Regulates IgE-mediated Mast Cell Activation. 2017; 30(2), 53-60. Available from: doi:10.11637/aba.2017.30.2.53

Prashanta Silwal, KeunA Shin, Choi Seulgi, Uk Namgung, 이찬용, Heo Jun Young, Kyu Lim, Park, Jong-Il, Ki-Hwan Kim and Park, Seung-Kiel. "Tryptophan Negatively Regulates IgE-mediated Mast Cell Activation" Anatomy & Biological Anthropology 30, no.2 (2017) : 53-60.doi: 10.11637/aba.2017.30.2.53

Prashanta Silwal; KeunA Shin; Choi Seulgi; Uk Namgung; 이찬용; Heo Jun Young; Kyu Lim; Park, Jong-Il; Ki-Hwan Kim; Park, Seung-Kiel. Tryptophan Negatively Regulates IgE-mediated Mast Cell Activation. Anatomy & Biological Anthropology, 30(2), 53-60. doi: 10.11637/aba.2017.30.2.53

Prashanta Silwal; KeunA Shin; Choi Seulgi; Uk Namgung; 이찬용; Heo Jun Young; Kyu Lim; Park, Jong-Il; Ki-Hwan Kim; Park, Seung-Kiel. Tryptophan Negatively Regulates IgE-mediated Mast Cell Activation. Anatomy & Biological Anthropology. 2017; 30(2) 53-60. doi: 10.11637/aba.2017.30.2.53

Prashanta Silwal, KeunA Shin, Choi Seulgi, Uk Namgung, 이찬용, Heo Jun Young, Kyu Lim, Park, Jong-Il, Ki-Hwan Kim, Park, Seung-Kiel. Tryptophan Negatively Regulates IgE-mediated Mast Cell Activation. 2017; 30(2), 53-60. Available from: doi:10.11637/aba.2017.30.2.53

Prashanta Silwal, KeunA Shin, Choi Seulgi, Uk Namgung, 이찬용, Heo Jun Young, Kyu Lim, Park, Jong-Il, Ki-Hwan Kim and Park, Seung-Kiel. "Tryptophan Negatively Regulates IgE-mediated Mast Cell Activation" Anatomy & Biological Anthropology 30, no.2 (2017) : 53-60.doi: 10.11637/aba.2017.30.2.53