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@article{ART002358065},
author={LEE HONG JU and Choi, Byung-Tae},
title={Effects of α-asarone on Proliferation and Differentiation of Neural Progenitor Cells},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2018},
volume={31},
number={2},
pages={41-49},
doi={10.11637/aba.2018.31.2.41}

TY - JOUR
AU - LEE HONG JU
AU - Choi, Byung-Tae
TI - Effects of α-asarone on Proliferation and Differentiation of Neural Progenitor Cells
JO - Anatomy & Biological Anthropology
PY - 2018
VL - 31
IS - 2
PB - 대한체질인류학회
SP - 41
EP - 49
SN - 2671-5651
AB - This study investigated whether α-asarone could promote proliferation and differentiation of neural progenitor cells into the neuronal cell types in in vitro and ex vivo studies. For in vitro assay, neural progenitor cells were isolated from fetal cerebral cortex (E15) and checked cell proliferation rate and neural progenitor cell marker in neurospheres. Treatment of α-asarone, particularly at a concentration of 3 μM, promoted the proliferation of neural progenitor cells and effectively differentiated neural progenitor cells into neurons. For ex vivo assay, a hippocampi slice culture system from 7 day postnatal rat fetuses was used. Although slight tissue damage was observed in the hippocampus after the high concentration (100 μM) of α-asarone, however, α-asarone enhanced the proliferation of neural progenitor cells in dentate gyrus region and also effectively differentiated into neuroblast at concentration of 30 μM. Consequently, α-asarone promotes the proliferation of neural progenitor cells and effectively differentiates neural progenitor cells into neurons. Therefore, our results support the therapeutic benefits of α-asarone for treating neurodegenerative diseases.
KW - α-asarone;Neural progenitor cell;Hippocampus;Proliferation;Differentiation
DO - 10.11637/aba.2018.31.2.41
ER -

LEE HONG JU and Choi, Byung-Tae. (2018). Effects of α-asarone on Proliferation and Differentiation of Neural Progenitor Cells. Anatomy & Biological Anthropology, 31(2), 41-49.

LEE HONG JU and Choi, Byung-Tae. 2018, "Effects of α-asarone on Proliferation and Differentiation of Neural Progenitor Cells", Anatomy & Biological Anthropology, vol.31, no.2 pp.41-49. Available from: doi:10.11637/aba.2018.31.2.41

LEE HONG JU, Choi, Byung-Tae "Effects of α-asarone on Proliferation and Differentiation of Neural Progenitor Cells" Anatomy & Biological Anthropology 31.2 pp.41-49 (2018) : 41.

LEE HONG JU, Choi, Byung-Tae. Effects of α-asarone on Proliferation and Differentiation of Neural Progenitor Cells. 2018; 31(2), 41-49. Available from: doi:10.11637/aba.2018.31.2.41

LEE HONG JU and Choi, Byung-Tae. "Effects of α-asarone on Proliferation and Differentiation of Neural Progenitor Cells" Anatomy & Biological Anthropology 31, no.2 (2018) : 41-49.doi: 10.11637/aba.2018.31.2.41

LEE HONG JU; Choi, Byung-Tae. Effects of α-asarone on Proliferation and Differentiation of Neural Progenitor Cells. Anatomy & Biological Anthropology, 31(2), 41-49. doi: 10.11637/aba.2018.31.2.41

LEE HONG JU; Choi, Byung-Tae. Effects of α-asarone on Proliferation and Differentiation of Neural Progenitor Cells. Anatomy & Biological Anthropology. 2018; 31(2) 41-49. doi: 10.11637/aba.2018.31.2.41

LEE HONG JU, Choi, Byung-Tae. Effects of α-asarone on Proliferation and Differentiation of Neural Progenitor Cells. 2018; 31(2), 41-49. Available from: doi:10.11637/aba.2018.31.2.41

LEE HONG JU and Choi, Byung-Tae. "Effects of α-asarone on Proliferation and Differentiation of Neural Progenitor Cells" Anatomy & Biological Anthropology 31, no.2 (2018) : 41-49.doi: 10.11637/aba.2018.31.2.41