Inhibitory Effects of CD99-derived Peptide CD99CRIII3 on the Extravasation of Monocytes and Inflammatory Reactions in Contact Dermatitis Mouse Model

주현미; Park Kyeong Han (박경한)

doi:10.11637/aba.2018.31.4.143

Inhibitory Effects of CD99-derived Peptide CD99CRIII3 on the Extravasation of Monocytes and Inflammatory Reactions in Contact Dermatitis Mouse Model

Anatomy & Biological Anthropology
Abbr : Anat Biol Anthropol
2018, 31(4), pp.143~149
DOI : 10.11637/aba.2018.31.4.143
Publisher : 대한체질인류학회
Research Area : Medicine and Pharmacy > Anatomy

주현미 ¹, Park Kyeong Han ²

¹강원대학교 의학전문대학원 해부세포생물학교실
²강원대학교

Accredited

ABSTRACT

Leucocyte extravasation has been known to play an important role in inflammatory reactions including contact dermatitis. Previous studies suggested that CD99 regulates β1 integrin activity and may be a novel therapeutic target molecule for inflammatory diseases. In this study, the effects of CD99-derived peptide, CD99CRIII3, on inflammatory reactions in contact dermatitis mouse model were investigated. CD99CRIII3 decreased β1-integrin activity in human monocytic U937 cells. CD99CRIII3 inhibited the adhesion of U937 monocytes to human umbilical vein endothelial cells and their extravasation through human umbilical vein endothelial cells. CD99CRIII3 reduced inflammation in the phorbol myristate acetate-induced contact dermatitis mice in a dose-dependent manner. These results indicate that CD99CRIII3 suppresses the extravasation of monocytes and inflammatory reactions in the animal model of the contact dermatitis, suggesting that CD99CRIII3 could be a new drug candidate against inflammatory skin diseases.

KEYWORDS

CD99-derived peptide, Contact dermatitis, CD99, Inflammation

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* References for papers published after 2023 are currently being built.

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Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Inhibitory Effects of CD99-derived Peptide CD99CRIII3 on the Extravasation of Monocytes and Inflammatory Reactions in Contact Dermatitis Mouse Model

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Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Inhibitory Effects of CD99-derived Peptide CD99CRIII3 on the Extravasation of Monocytes and Inflammatory Reactions in Contact Dermatitis Mouse Model

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