Effects of Intermittent Fasting on Splenic Galectin-3 Protein Expression in High-fat Diet-fed Mice (간헐절식에 의한 고지방식이 생쥐의 비장 갈렉틴-3단백발현에 미치는 영향)

Lee, Chung Eun (이정은)

doi:10.11637/aba.2023.36.4.209

Effects of Intermittent Fasting on Splenic Galectin-3 Protein Expression in High-fat Diet-fed Mice

Anatomy & Biological Anthropology
Abbr : Anat Biol Anthropol
2023, 36(4), pp.209~217
DOI : 10.11637/aba.2023.36.4.209
Publisher : 대한체질인류학회
Research Area : Medicine and Pharmacy > Anatomy
Received : November 7, 2023
Accepted : December 4, 2023
Published : December 31, 2023

Lee, Chung Eun ¹

¹경상국립대학교

Accredited

ABSTRACT

Non-alcoholic fatty liver disease (NAFLD) causes the increase of splenic macrophages. Galectin-3 plays an important role in the phagocytosis of macrophages. However, the role of splenic galectin-3 in NAFLD remains unclear. This study determines the effects of intermittent fasting (IF) on splenic galectin-3 protein expression in high-fat diet (HFD)-fed mice. Mice were fed an HFD for 30 weeks and then either continued on the HFD or subjected to IF for the last 22 weeks. IF led to the reduction of spleen weight and attenuated NAFLD in HFD-fed mice. In particular, total splenic iron concentration was decreased in HFD-fed mice compared to NDꠓfed mice. However, IF reversed the total iron level. Increased splenic galectin-3 expression in HFD-fed mice was significantly attenuated by IF. HFD+IF-fed mice had fewer galectin-3-positive macrophages in the spleen than those of HFD-fed mice. These findings indicate that IF can improve galectin-3-mediated phagocytosis in mice with NAFLD.

KEYWORDS

Intermittent fasting, NAFLD, Spleen, Galectin-3, Mouse

Citation status

* References for papers published after 2023 are currently being built.

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Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Effects of Intermittent Fasting on Splenic Galectin-3 Protein Expression in High-fat Diet-fed Mice

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* References for papers published after 2023 are currently being built.

Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Effects of Intermittent Fasting on Splenic Galectin-3 Protein Expression in High-fat Diet-fed Mice

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