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Clinical and Prognostic Significance of TSC2 and TSC1 Expressions in Rectal Cancer

  • Anatomy & Biological Anthropology
  • Abbr : Anat Biol Anthropol
  • 2024, 37(4), pp.303~311
  • DOI : 10.11637/aba.2024.37.4.303
  • Publisher : 대한체질인류학회
  • Research Area : Medicine and Pharmacy > Anatomy
  • Received : October 15, 2024
  • Accepted : December 23, 2024
  • Published : December 31, 2024

JUNG SOO JUNG 1,  Lee june chai 2,  BAE ANNA 3,  Park, Jongho 3,  Lee, Jae-Ho 3,  Kim Jong Wan 4

1경북대학교 의과대학 생리학교실
2계명대학교 의과대학 의학과
3계명대학교 의과대학 해부학교실
4동의과학대학교 임상병리학과

Accredited

ABSTRACT

TSC1 is a crucial component of the mTOR pathway, impacting cell growth, proliferation, and autophagy, while TSC2 is a tumor suppressor gene that regulates cell growth and is associated with the mTOR signaling pathway. In the present study, we analyzed TSC1 and TSC2 mRNA expression levels in rectal cancer, and evaluated clinicopathological and prognostic characteristics of TSC1 and TSC2. TSC1 and TSC2 mRNA expression was examined in various cancer types using The Cancer Genome Atlas (TCGA) data. The patients were split into two subgroups, each comprising 50% of the total, based on the TSC gene expression levels. This division was made to assess the clinical characteristics associated with the expression of TSC1 and TSC2 genes. Lower TSC1 expression was linked to venous invasion in rectal cancer patients, and there was also a related trend with lymphatic invasion, although it didn’t reach statistical significance. Lower TSC2 expression was observed in younger patients and had some associations with sex and M stage, but these correlations were not statistically significant. When it came to survival analysis, TSC1 expression did not significantly impact overall survival, while higher TSC2 expression was associated with a poorer prognosis in rectal cancer. TSC1 and TSC2 may have important role in rectal cancer and its molecular mechanisms and clinical characteristics should be studied further.

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