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@article{ART003245722},
author={Hyunsoo Park and Jae Young Choe and Lee june chai and Lee, Jae-Ho},
title={CHEK1 expression was associated with the prognosis in colon cancers},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2025},
volume={38},
number={3},
pages={263-268}

TY - JOUR
AU - Hyunsoo Park
AU - Jae Young Choe
AU - Lee june chai
AU - Lee, Jae-Ho
TI - CHEK1 expression was associated with the prognosis in colon cancers
JO - Anatomy & Biological Anthropology
PY - 2025
VL - 38
IS - 3
PB - 대한체질인류학회
SP - 263
EP - 268
SN - 2671-5651
AB - Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, yet the molecular determinants of its progression are not fully understood. Although CHEK1 overexpression has been associated with poor prognosis in several malignancies, its role in CRC remains unclear. This study aimed to investigate the clinical and prognostic value of the CHEK1 gene in CRC. CHEK1 expression was analyzed across various cancer types, and its prognostic significance in CRC was further evaluated using data from The Cancer Genome Atlas (TCGA). Higher CHEK1 expression was associated with age in rectal cancer patients and correlated with early pathological stage, N0 stage, M0 stage, anatomic neoplasm type, and MSI status in colon cancer. Survival analysis revealed that higher CHEK1 expression was significantly associated with favorable prognosis in colon cancer. However, in rectal cancer, the association was not statistically significant, likely due to the small sample size. These findings suggest that CHEK1 may be potential as a prognostic biomarker in CRC, and further studies are warranted to elucidate its molecular mechanisms and prognostic implications
KW - CHEK1;TCGA;colon cancer;rectal cancer
DO -
UR -
ER -

Hyunsoo Park, Jae Young Choe, Lee june chai and Lee, Jae-Ho. (2025). CHEK1 expression was associated with the prognosis in colon cancers. Anatomy & Biological Anthropology, 38(3), 263-268.

Hyunsoo Park, Jae Young Choe, Lee june chai and Lee, Jae-Ho. 2025, "CHEK1 expression was associated with the prognosis in colon cancers", Anatomy & Biological Anthropology, vol.38, no.3 pp.263-268.

Hyunsoo Park, Jae Young Choe, Lee june chai, Lee, Jae-Ho "CHEK1 expression was associated with the prognosis in colon cancers" Anatomy & Biological Anthropology 38.3 pp.263-268 (2025) : 263.

Hyunsoo Park, Jae Young Choe, Lee june chai, Lee, Jae-Ho. CHEK1 expression was associated with the prognosis in colon cancers. 2025; 38(3), 263-268.

Hyunsoo Park, Jae Young Choe, Lee june chai and Lee, Jae-Ho. "CHEK1 expression was associated with the prognosis in colon cancers" Anatomy & Biological Anthropology 38, no.3 (2025) : 263-268.

Hyunsoo Park; Jae Young Choe; Lee june chai; Lee, Jae-Ho. CHEK1 expression was associated with the prognosis in colon cancers. Anatomy & Biological Anthropology, 38(3), 263-268.

Hyunsoo Park; Jae Young Choe; Lee june chai; Lee, Jae-Ho. CHEK1 expression was associated with the prognosis in colon cancers. Anatomy & Biological Anthropology. 2025; 38(3) 263-268.

Hyunsoo Park, Jae Young Choe, Lee june chai, Lee, Jae-Ho. CHEK1 expression was associated with the prognosis in colon cancers. 2025; 38(3), 263-268.

Hyunsoo Park, Jae Young Choe, Lee june chai and Lee, Jae-Ho. "CHEK1 expression was associated with the prognosis in colon cancers" Anatomy & Biological Anthropology 38, no.3 (2025) : 263-268.