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Clinical and Prognostic Value of CPT2 in Colorectal Cancer

  • Anatomy & Biological Anthropology
  • Abbr : Anat Biol Anthropol
  • 2026, 39(1), pp.53~61
  • DOI : 10.11637/aba.2026.39.1.53
  • Publisher : 대한체질인류학회
  • Research Area : Medicine and Pharmacy > Anatomy
  • Received : February 26, 2026
  • Accepted : March 26, 2026
  • Published : March 31, 2026

황진호 1,  Park Jae-Hee 2,  Lee, Jae-Ho ORD ID 3,  Tae-Young Kim 3

1계명대학교 의과대학
2계명문화대학교 응급구조학과
3계명대학교 의과대학 해부학교실

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ABSTRACT

Carnitine palmitoyltransferase 2 (CPT2) encodes a protein localized to the inner mitochondrial membrane, responsible for catalyzing the conversion of acylcarnitine back to acyl-CoA in fatty acid oxidation (FAO). It plays a vital role in maintaining cellular energy homeostasis and promoting β-oxidation; therefore, dysregulated CPT2 activity has been implicated in various pathologies, including cancers. This study aimed to prove the clinical and prognostic value of the CPT2 gene in colorectal cancer (CRC). We utilized primary data from The Cancer Genome Atlas (TCGA) to evaluate overall survival and determine the prognostic significance of CPT2 mRNA expression in CRC. In colon cancer, CPT2 expression was significantly associated with lymphatic invasion (p=0.045), pathologic stage (p=0.003), N stage (p=0.004), MSI status (p=0.009), and anatomic tumor location (p<0.001). No significant associations were observed with most clinicopathologic variables in rectal cancer, although T stage showed a borderline association (p=0.069). Correlation analysis demonstrated that CPT2 expression in colon cancer was positively correlated with TP53 expression (R=0.152, p=0.001) and negatively correlated with CEA levels (R=-0.156, p=0.009), while no significant correlations were observed with APC or KRAS. Survival analysis revealed that CPT2 expression was significantly associated with overall survival in colon cancer (p=0.003) but not in rectal cancer (p=0.653). Our findings suggest that lower CPT2 mRNA expression is significantly associated with aggressive clinicopathological features and poor prognosis, particularly in colon cancer. CPT2 may serve as a potential biomarker for risk stratification and a therapeutic target in CRC management.

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