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@article{ART003390166},
author={Hwang Hyo In and Park Junghee and 신혜경 and Yoon-Young Chung and KIM DONGJOON and JUN, YONGHYUN},
title={Expression Changes of Neuroprotective Signaling Molecules in the Mouse Cortex Following Permanent Middle Cerebral Artery Occlusion - Neuroprotective Signaling In pMCAO -},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2026},
volume={39},
number={3},
pages={251-258},
doi={10.11637/aba.2026.39.3.251}

TY - JOUR
AU - Hwang Hyo In
AU - Park Junghee
AU - 신혜경
AU - Yoon-Young Chung
AU - KIM DONGJOON
AU - JUN, YONGHYUN
TI - Expression Changes of Neuroprotective Signaling Molecules in the Mouse Cortex Following Permanent Middle Cerebral Artery Occlusion - Neuroprotective Signaling In pMCAO -
JO - Anatomy & Biological Anthropology
PY - 2026
VL - 39
IS - 3
PB - 대한체질인류학회
SP - 251
EP - 258
SN - 2671-5651
AB - Oxidative stress and altered intracellular signaling contribute to ischemic brain injury; however, molecular alterations during the subacute phase following permanent cerebral ischemia remain incompletely understood. In this study, nine-week-old male mice underwent permanent middle cerebral artery occlusion using the intraluminal filament method, and ipsilateral cortical tissue was collected three days after ischemia. Western blot analysis was performed to evaluate nuclear factor erythroid 2-related factor 2, heme oxygenase-1, brain- derived neurotrophic factor, and the activation of protein kinase B and extracellular signal-regulated kinase. Nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 expression levels were significantly decreased following permanent cerebral ischemia, whereas brain-derived neurotrophic factor expression was significantly increased. Protein kinase B activation, assessed by the ratio of its phosphorylated to total form, was significantly reduced, whereas extracellular signal-regulated kinase activation showed no significant difference between the control and ischemia groups. These findings demonstrate distinct alterations in antioxidant defense, neurotrophic responses, and intracellular survival signaling in the cerebral cortex three days after permanent cerebral ischemia and provide insight into molecular responses associated with the subacute stage of ischemic injury.
KW - MCAO;NRF;HO-1;BDNF;AKT
DO - 10.11637/aba.2026.39.3.251
ER -

Hwang Hyo In, Park Junghee, 신혜경, Yoon-Young Chung, KIM DONGJOON and JUN, YONGHYUN. (2026). Expression Changes of Neuroprotective Signaling Molecules in the Mouse Cortex Following Permanent Middle Cerebral Artery Occlusion - Neuroprotective Signaling In pMCAO -. Anatomy & Biological Anthropology, 39(3), 251-258.

Hwang Hyo In, Park Junghee, 신혜경, Yoon-Young Chung, KIM DONGJOON and JUN, YONGHYUN. 2026, "Expression Changes of Neuroprotective Signaling Molecules in the Mouse Cortex Following Permanent Middle Cerebral Artery Occlusion - Neuroprotective Signaling In pMCAO -", Anatomy & Biological Anthropology, vol.39, no.3 pp.251-258. Available from: doi:10.11637/aba.2026.39.3.251

Hwang Hyo In, Park Junghee, 신혜경, Yoon-Young Chung, KIM DONGJOON, JUN, YONGHYUN "Expression Changes of Neuroprotective Signaling Molecules in the Mouse Cortex Following Permanent Middle Cerebral Artery Occlusion - Neuroprotective Signaling In pMCAO -" Anatomy & Biological Anthropology 39.3 pp.251-258 (2026) : 251.

Hwang Hyo In, Park Junghee, 신혜경, Yoon-Young Chung, KIM DONGJOON, JUN, YONGHYUN. Expression Changes of Neuroprotective Signaling Molecules in the Mouse Cortex Following Permanent Middle Cerebral Artery Occlusion - Neuroprotective Signaling In pMCAO -. 2026; 39(3), 251-258. Available from: doi:10.11637/aba.2026.39.3.251

Hwang Hyo In, Park Junghee, 신혜경, Yoon-Young Chung, KIM DONGJOON and JUN, YONGHYUN. "Expression Changes of Neuroprotective Signaling Molecules in the Mouse Cortex Following Permanent Middle Cerebral Artery Occlusion - Neuroprotective Signaling In pMCAO -" Anatomy & Biological Anthropology 39, no.3 (2026) : 251-258.doi: 10.11637/aba.2026.39.3.251

Hwang Hyo In; Park Junghee; 신혜경; Yoon-Young Chung; KIM DONGJOON; JUN, YONGHYUN. Expression Changes of Neuroprotective Signaling Molecules in the Mouse Cortex Following Permanent Middle Cerebral Artery Occlusion - Neuroprotective Signaling In pMCAO -. Anatomy & Biological Anthropology, 39(3), 251-258. doi: 10.11637/aba.2026.39.3.251

Hwang Hyo In; Park Junghee; 신혜경; Yoon-Young Chung; KIM DONGJOON; JUN, YONGHYUN. Expression Changes of Neuroprotective Signaling Molecules in the Mouse Cortex Following Permanent Middle Cerebral Artery Occlusion - Neuroprotective Signaling In pMCAO -. Anatomy & Biological Anthropology. 2026; 39(3) 251-258. doi: 10.11637/aba.2026.39.3.251

Hwang Hyo In, Park Junghee, 신혜경, Yoon-Young Chung, KIM DONGJOON, JUN, YONGHYUN. Expression Changes of Neuroprotective Signaling Molecules in the Mouse Cortex Following Permanent Middle Cerebral Artery Occlusion - Neuroprotective Signaling In pMCAO -. 2026; 39(3), 251-258. Available from: doi:10.11637/aba.2026.39.3.251

Hwang Hyo In, Park Junghee, 신혜경, Yoon-Young Chung, KIM DONGJOON and JUN, YONGHYUN. "Expression Changes of Neuroprotective Signaling Molecules in the Mouse Cortex Following Permanent Middle Cerebral Artery Occlusion - Neuroprotective Signaling In pMCAO -" Anatomy & Biological Anthropology 39, no.3 (2026) : 251-258.doi: 10.11637/aba.2026.39.3.251