@article{ART003390178},
author={이나윤 and 천아영 and Hyunbin Cha and Lee, Jae-Ho and Park Jae-Hee},
title={Distinct Clinicopathological and Prognostic Associations of KCNQ1 Expression in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2026},
volume={39},
number={3},
pages={301-306},
doi={10.11637/aba.2026.39.3.301}
TY - JOUR
AU - 이나윤
AU - 천아영
AU - Hyunbin Cha
AU - Lee, Jae-Ho
AU - Park Jae-Hee
TI - Distinct Clinicopathological and Prognostic Associations of KCNQ1 Expression in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma
JO - Anatomy & Biological Anthropology
PY - 2026
VL - 39
IS - 3
PB - 대한체질인류학회
SP - 301
EP - 306
SN - 2671-5651
AB - KCNQ1 (potassium voltage-gated channel subfamily Q member 1) is a voltage-gated potassium channel subunit involved in the regulation of membrane potential and cellular ion homeostasis. Although ion channels have been increasingly recognized as important regulators of cancer biology, the clinical significance of KCNQ1 expression in non-small cell lung cancer (NSCLC) according to histological subtype remains unclear. This study aimed to investigate the association between KCNQ1 expression and clinicopathological characteristics and overall survival in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). RNA sequencing and clinical data of patients with LUAD and LUSC were obtained from The Cancer Genome Atlas (TCGA) database. Patients were divided into high- and low-KCNQ1 expression groups based on the median expression value, and the associations between KCNQ1 expression and clinicopathological variables were analyzed. Overall survival was evaluated using Kaplan-Meier survival analysis. KCNQ1 expression showed different clinical associations according to the histological subtype of NSCLC. In LUSC, patients with high KCNQ1 expression demonstrated significantly poorer overall survival than those with low expression. In contrast, no significant association between KCNQ1 expression and overall survival was observed in LUAD. These findings suggest that the clinical relevance of KCNQ1 expression may differ between LUAD and LUSC. KCNQ1 expression may have subtype-specific clinical relevance, particularly in relation to survival in LUSC, although its independent prognostic significance remains uncertain. Further studies involving tissue-level validation and functional experiments are required to clarify the biological mechanisms underlying the association between KCNQ1 expression and NSCLC progression.
KW - KCNQ1;Non-small cell lung cancer;Lung adenocarcinoma;Lung squamous cell carcinoma;TCGA
DO - 10.11637/aba.2026.39.3.301
ER -
이나윤, 천아영, Hyunbin Cha, Lee, Jae-Ho and Park Jae-Hee. (2026). Distinct Clinicopathological and Prognostic Associations of KCNQ1 Expression in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma. Anatomy & Biological Anthropology, 39(3), 301-306.
이나윤, 천아영, Hyunbin Cha, Lee, Jae-Ho and Park Jae-Hee. 2026, "Distinct Clinicopathological and Prognostic Associations of KCNQ1 Expression in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma", Anatomy & Biological Anthropology, vol.39, no.3 pp.301-306. Available from: doi:10.11637/aba.2026.39.3.301
이나윤, 천아영, Hyunbin Cha, Lee, Jae-Ho, Park Jae-Hee "Distinct Clinicopathological and Prognostic Associations of KCNQ1 Expression in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma" Anatomy & Biological Anthropology 39.3 pp.301-306 (2026) : 301.
이나윤, 천아영, Hyunbin Cha, Lee, Jae-Ho, Park Jae-Hee. Distinct Clinicopathological and Prognostic Associations of KCNQ1 Expression in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma. 2026; 39(3), 301-306. Available from: doi:10.11637/aba.2026.39.3.301
이나윤, 천아영, Hyunbin Cha, Lee, Jae-Ho and Park Jae-Hee. "Distinct Clinicopathological and Prognostic Associations of KCNQ1 Expression in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma" Anatomy & Biological Anthropology 39, no.3 (2026) : 301-306.doi: 10.11637/aba.2026.39.3.301
이나윤; 천아영; Hyunbin Cha; Lee, Jae-Ho; Park Jae-Hee. Distinct Clinicopathological and Prognostic Associations of KCNQ1 Expression in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma. Anatomy & Biological Anthropology, 39(3), 301-306. doi: 10.11637/aba.2026.39.3.301
이나윤; 천아영; Hyunbin Cha; Lee, Jae-Ho; Park Jae-Hee. Distinct Clinicopathological and Prognostic Associations of KCNQ1 Expression in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma. Anatomy & Biological Anthropology. 2026; 39(3) 301-306. doi: 10.11637/aba.2026.39.3.301
이나윤, 천아영, Hyunbin Cha, Lee, Jae-Ho, Park Jae-Hee. Distinct Clinicopathological and Prognostic Associations of KCNQ1 Expression in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma. 2026; 39(3), 301-306. Available from: doi:10.11637/aba.2026.39.3.301
이나윤, 천아영, Hyunbin Cha, Lee, Jae-Ho and Park Jae-Hee. "Distinct Clinicopathological and Prognostic Associations of KCNQ1 Expression in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma" Anatomy & Biological Anthropology 39, no.3 (2026) : 301-306.doi: 10.11637/aba.2026.39.3.301
1,
Park Jae-Hee