@article{ART002587643},
author={Haorong Lin1 and Jia Zhang and Chaochang Yu and Yan Lu and Jie Ning and Sixian Le and Yue Li and Lin-quan Zang},
title={Oral delivery of insulin via mesoporous carbon nanoparticles for colonic release allows glycemic control in diabetic rats},
journal={Carbon Letters},
issn={1976-4251},
year={2019},
volume={29},
number={2},
pages={133-143},
doi={10.1007/s42823-019-00033-z}
TY - JOUR
AU - Haorong Lin1
AU - Jia Zhang
AU - Chaochang Yu
AU - Yan Lu
AU - Jie Ning
AU - Sixian Le
AU - Yue Li
AU - Lin-quan Zang
TI - Oral delivery of insulin via mesoporous carbon nanoparticles for colonic release allows glycemic control in diabetic rats
JO - Carbon Letters
PY - 2019
VL - 29
IS - 2
PB - Korean Carbon Society
SP - 133
EP - 143
SN - 1976-4251
AB - In this article, a new type of mesoporous carbon nanoparticles (MCN) was fabricated as a potential oral delivery system of insulin to reduce the adverse reactions by hypodermic injection. The mesoporous carbon nanoparticles-carried insulin (MCNI) was studied using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Fourier transform infrared spectroscopy (FT-IR) compared with the blank MCNs. The Brunauer–Emmett–Teller (BET) method was utilized to calculate the specific surface area. The pore volume and pore size distribution (PSD) curves were calculated by Barrett–Joyner–Halenda (BJH) model. The entrapment efficiency (EE%) and loading content (LC%) of insulin onto the MCNs were determined by RP-HPLC. In vitro insulin release from MCNI was determined in simulated intestinal fluid. To evaluate the pharmacodynamics of MCNIs orally, the variation of glycemia of diabetic rats after oral administration of MCNIs was compared with the rats receiving hypodermic injection of insulin. Besides, the absorption of FITC-labeled MCNs in HCT-116 cells was tested. The results showed that there is significant difference between MCNs and MCNIs through SEM, TEM, and FT-IR. The entrapment efficiency, loading content and in vitro insulin release met the requirements of the pharmacodynamic study. The specific surface area, pore volume and pore size of MCNIs were significantly decreased compared to that of MCNs. The pharmacodynamics study showed that the blood sugar level was significantly decreased after the oral administration of MCNIs. The FITC-labeled MCNs showed significant absorption in HCT-116 cells. The MCNIs were successfully synthesized with commendable entrapment efficiency and loading content which preferably decreased the blood sugar in diabetes rats via oral administration.
KW - Insulin · Mesoporous carbon · Nanoparticles · Diabetes mellitus · Oral administration
DO - 10.1007/s42823-019-00033-z
ER -
Haorong Lin1, Jia Zhang, Chaochang Yu, Yan Lu, Jie Ning, Sixian Le, Yue Li and Lin-quan Zang. (2019). Oral delivery of insulin via mesoporous carbon nanoparticles for colonic release allows glycemic control in diabetic rats. Carbon Letters, 29(2), 133-143.
Haorong Lin1, Jia Zhang, Chaochang Yu, Yan Lu, Jie Ning, Sixian Le, Yue Li and Lin-quan Zang. 2019, "Oral delivery of insulin via mesoporous carbon nanoparticles for colonic release allows glycemic control in diabetic rats", Carbon Letters, vol.29, no.2 pp.133-143. Available from: doi:10.1007/s42823-019-00033-z
Haorong Lin1, Jia Zhang, Chaochang Yu, Yan Lu, Jie Ning, Sixian Le, Yue Li, Lin-quan Zang "Oral delivery of insulin via mesoporous carbon nanoparticles for colonic release allows glycemic control in diabetic rats" Carbon Letters 29.2 pp.133-143 (2019) : 133.
Haorong Lin1, Jia Zhang, Chaochang Yu, Yan Lu, Jie Ning, Sixian Le, Yue Li, Lin-quan Zang. Oral delivery of insulin via mesoporous carbon nanoparticles for colonic release allows glycemic control in diabetic rats. 2019; 29(2), 133-143. Available from: doi:10.1007/s42823-019-00033-z
Haorong Lin1, Jia Zhang, Chaochang Yu, Yan Lu, Jie Ning, Sixian Le, Yue Li and Lin-quan Zang. "Oral delivery of insulin via mesoporous carbon nanoparticles for colonic release allows glycemic control in diabetic rats" Carbon Letters 29, no.2 (2019) : 133-143.doi: 10.1007/s42823-019-00033-z
Haorong Lin1; Jia Zhang; Chaochang Yu; Yan Lu; Jie Ning; Sixian Le; Yue Li; Lin-quan Zang. Oral delivery of insulin via mesoporous carbon nanoparticles for colonic release allows glycemic control in diabetic rats. Carbon Letters, 29(2), 133-143. doi: 10.1007/s42823-019-00033-z
Haorong Lin1; Jia Zhang; Chaochang Yu; Yan Lu; Jie Ning; Sixian Le; Yue Li; Lin-quan Zang. Oral delivery of insulin via mesoporous carbon nanoparticles for colonic release allows glycemic control in diabetic rats. Carbon Letters. 2019; 29(2) 133-143. doi: 10.1007/s42823-019-00033-z
Haorong Lin1, Jia Zhang, Chaochang Yu, Yan Lu, Jie Ning, Sixian Le, Yue Li, Lin-quan Zang. Oral delivery of insulin via mesoporous carbon nanoparticles for colonic release allows glycemic control in diabetic rats. 2019; 29(2), 133-143. Available from: doi:10.1007/s42823-019-00033-z
Haorong Lin1, Jia Zhang, Chaochang Yu, Yan Lu, Jie Ning, Sixian Le, Yue Li and Lin-quan Zang. "Oral delivery of insulin via mesoporous carbon nanoparticles for colonic release allows glycemic control in diabetic rats" Carbon Letters 29, no.2 (2019) : 133-143.doi: 10.1007/s42823-019-00033-z