KJCKorea
Journal Central

@article{ART002695580},
author={Sharma Suraj and Naskar Sweet and Kuotsu Ketousetuo},
title={Metronomic chemotherapy of carboplatin-loaded PEGylated MWCNTs: synthesis, characterization and in vitro toxicity in human breast cancer},
journal={Carbon Letters},
issn={1976-4251},
year={2020},
volume={30},
number={4},
pages={435-447},
doi={10.1007/s42823-019-00113-0}

TY - JOUR
AU - Sharma Suraj
AU - Naskar Sweet
AU - Kuotsu Ketousetuo
TI - Metronomic chemotherapy of carboplatin-loaded PEGylated MWCNTs: synthesis, characterization and in vitro toxicity in human breast cancer
JO - Carbon Letters
PY - 2020
VL - 30
IS - 4
PB - Korean Carbon Society
SP - 435
EP - 447
SN - 1976-4251
AB - Our objective of this study is to design and develop a polyethylene glycol (PEG2000)-modifed multiwall carbon nanotube (PEGylated MWCNT) formulation for oral controlled metronomic chemotherapeutic drug delivery. Multiwall carbon nano�tubes undergo various chemical modifcations including oxidation with strong acids, conjugation of polyethylene glycol, and coating with cellulose acetate phthalate which resulted in the formation of aqueous dispersion and prevention of drug degradation in acidic environment. Advanced analytical procedure such as Fourier transform infra-red, X-ray difraction, diferential scanning calorimetry, thermal gravimetric analysis, transmission electron microscopy, and dynamic light scat�tering techniques were used to evaluate physicochemical characterization. We also performed in vitro cytotoxic study by MTT assay and results revealed that carboplatin-loaded PEGylated MWCNTs did not show signifcant detrimental efect on the viability of MDA-MB-231 (human breast cancer) cells. The maximum encapsulation and drug-loading capacity were determined to be 71.58±0.04 and 39.62±0.07%, respectively. The release of carboplatin from PEGylated MWCNTs was investigated at simulated intestinal fuid (SIF), pH 6.8, after optimizing at simulated gastric fuid (SGF), pH 1.2, by enteric coating. Enteric-coated PEGylated MWCNTs exhibit pH-responsive drug activity in a sustained manner especially at pH 6.8. This surface modifcation strongly suggests that PEGylated MWCNTs could be a potential carrier for metronomic chemotherapeutic agent for high drug resistance, drug with maximum adverse efect and poorly oral bioavailable drugs.
KW - Multiwall carbon nanotubes (MWCNTs) · Cytotoxicity · Metronomic chemotherapeutic · Carboplatin (CP) · MDA-MB-231 cell line · In vitro release
DO - 10.1007/s42823-019-00113-0
ER -

Sharma Suraj, Naskar Sweet and Kuotsu Ketousetuo. (2020). Metronomic chemotherapy of carboplatin-loaded PEGylated MWCNTs: synthesis, characterization and in vitro toxicity in human breast cancer. Carbon Letters, 30(4), 435-447.

Sharma Suraj, Naskar Sweet and Kuotsu Ketousetuo. 2020, "Metronomic chemotherapy of carboplatin-loaded PEGylated MWCNTs: synthesis, characterization and in vitro toxicity in human breast cancer", Carbon Letters, vol.30, no.4 pp.435-447. Available from: doi:10.1007/s42823-019-00113-0

Sharma Suraj, Naskar Sweet, Kuotsu Ketousetuo "Metronomic chemotherapy of carboplatin-loaded PEGylated MWCNTs: synthesis, characterization and in vitro toxicity in human breast cancer" Carbon Letters 30.4 pp.435-447 (2020) : 435.

Sharma Suraj, Naskar Sweet, Kuotsu Ketousetuo. Metronomic chemotherapy of carboplatin-loaded PEGylated MWCNTs: synthesis, characterization and in vitro toxicity in human breast cancer. 2020; 30(4), 435-447. Available from: doi:10.1007/s42823-019-00113-0

Sharma Suraj, Naskar Sweet and Kuotsu Ketousetuo. "Metronomic chemotherapy of carboplatin-loaded PEGylated MWCNTs: synthesis, characterization and in vitro toxicity in human breast cancer" Carbon Letters 30, no.4 (2020) : 435-447.doi: 10.1007/s42823-019-00113-0

Sharma Suraj; Naskar Sweet; Kuotsu Ketousetuo. Metronomic chemotherapy of carboplatin-loaded PEGylated MWCNTs: synthesis, characterization and in vitro toxicity in human breast cancer. Carbon Letters, 30(4), 435-447. doi: 10.1007/s42823-019-00113-0

Sharma Suraj; Naskar Sweet; Kuotsu Ketousetuo. Metronomic chemotherapy of carboplatin-loaded PEGylated MWCNTs: synthesis, characterization and in vitro toxicity in human breast cancer. Carbon Letters. 2020; 30(4) 435-447. doi: 10.1007/s42823-019-00113-0

Sharma Suraj, Naskar Sweet, Kuotsu Ketousetuo. Metronomic chemotherapy of carboplatin-loaded PEGylated MWCNTs: synthesis, characterization and in vitro toxicity in human breast cancer. 2020; 30(4), 435-447. Available from: doi:10.1007/s42823-019-00113-0

Sharma Suraj, Naskar Sweet and Kuotsu Ketousetuo. "Metronomic chemotherapy of carboplatin-loaded PEGylated MWCNTs: synthesis, characterization and in vitro toxicity in human breast cancer" Carbon Letters 30, no.4 (2020) : 435-447.doi: 10.1007/s42823-019-00113-0