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Synthesis of quinozilinium fluoroborate salts from harmine

  • Carbon Letters
  • Abbr : Carbon Lett.
  • 2021, 31(2), pp.297-305
  • DOI : 10.1007/s42823-020-00165-7
  • Publisher : Korean Carbon Society
  • Research Area : Natural Science > Natural Science General > Other Natural Sciences General
  • Received : May 25, 2020
  • Accepted : July 7, 2020
  • Published : April 1, 2021

Musunuri Sivanath 1 Sreenivasulu Reddymasu 2 Mak Kit-Kay 3 Pichika Mallikarjuna Rao 3 Rao Mandava Venkata Basaveswara 4

1Department of Chemistry, ANR College, Gudivada
2University College of Engineering (Autonomous)
3International Medical University
4Krishna University

Accredited

ABSTRACT

Molecules possessing harmine moiety are reported to exhibit marked fungicidal and bactericidal activities. In this study, various quinozilinium tetrafluoroborate salts were synthesized using acylic and cyclic oxoketene dithioacetals followed by cycloaromatization from Harmine. All of these synthesized compounds were characterized by 1H NMR, 13C NMR, Mass and CHN analysis. This methodology would find wide usage in the preparation of indolo quinozilinium -based library of small molecules useful for medicinal chemistry and in drug discovery.

Citation status

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