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Carbon-based nanomaterials for CRISPR/Cas delivery: a perspective on the design approach

  • Carbon Letters
  • Abbr : Carbon Lett.
  • 2024, 34(1), pp.387~397
  • DOI : 10.1007/s42823-023-00655-4
  • Publisher : Korean Carbon Society
  • Research Area : Natural Science > Natural Science General > Other Natural Sciences General
  • Received : August 30, 2023
  • Accepted : October 20, 2023
  • Published : February 1, 2024

SAFARKHANI MOEIN 1 Saeb Mohammad Reza 2 Lee Jeong-Hwan 3 HUH YUN SUK 1 Rabiee Navid 4

1인하대학교
2Medical University of Gdańsk
3인하대학교 신소재공학과
4Macquarie University

Accredited

ABSTRACT

This perspective article delves into the evolving landscape of non-viral vectors for efficient CRISPR delivery, addressing the challenges associated with viral vectors and highlighting the potential of carbon-based nanomaterials as promising alternatives. The article underscores the importance of design strategies in enhancing the interactions between CRISPR components and carbon-based nanomaterials. Various design approaches are explored, including the incorporation of modified nanoparticles between carbonic layers and the creation of unique morphologies to facilitate optimal CRISPR interactions. Specific case studies are presented to exemplify the effectiveness of carbon-based nanomaterials in CRISPR delivery. This perspective sheds light on the dynamic field of non-viral CRISPR delivery vectors, emphasizing the significance of design strategies and showcasing the promising outcomes achieved through the utilization of carbon-based nanomaterials. The provided insights contribute to the ongoing efforts to develop efficient and safe methods for gene delivery and therapy.

Citation status

Scopus Citation Counts (4) This is the result of checking the information with the same ISSN, publication year, volume, and start page between articles in KCI and the SCOPUS journals. (as of 2025-01-01)

* References for papers published after 2023 are currently being built.