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Construction of graphene/AuNPs based amperometric immunosensor for detecting bladder cancer biomarker apolipoprotein A1

  • Carbon Letters
  • Abbr : Carbon Lett.
  • 2024, 34(3), pp.907~915
  • DOI : 10.1007/s42823-023-00595-z
  • Publisher : Korean Carbon Society
  • Research Area : Natural Science > Natural Science General > Other Natural Sciences General
  • Received : June 7, 2023
  • Accepted : August 30, 2023
  • Published : April 11, 2024

Jing Yang 1 Wang Xingyuan 1 Zhou Tingting 1 Wei Liangjun 1 Guo Meiling 1 Liu Yanan 1 Sun Xiaoqi 1 Wang Yanjie 1

1Harbin Medical University Cancer Hospital

Accredited

ABSTRACT

This paper presents the construction and characterization of an amperometric immunosensor based on the graphene/gold nanoparticles (AuNPs/GO) nanocomposite for the detection of the bladder cancer biomarker, apolipoprotein A1 (Apo-A1). The morphological analysis of the AuNPs/GO nanocomposite demonstrated an almost spherical shape of AuNPs and the successful coverage of their surface by graphene oxide. An increased G peak and decreased D peak after the association of AuNPs with GO, implied a reduction in graphene defects. The X-ray photoelectron spectroscopy (XPS) indicated a significant decrease in the quantity of oxygen-containing functional groups in the AuNPs/GO nanocomposite, as compared to the original GO. Furthermore, the developed sensor demonstrated commendable sensitivity and selectivity, with a wide linear range for Apo-A1 detection. Importantly, the immunosensor exhibited remarkable stability over a period of 14 days, signifying its potential for practical applications.

Citation status

* References for papers published after 2023 are currently being built.