Facile fabrication of CdS@GO binary nanocomposite coated GCE for separate and parallel electrochemical sensing of ascorbic acid, uric acid and nitrite

A. Dhamodharan; E. Murugan; Huan Pang; K. Perumal; K. Jhansirani; Yajun Gao

doi:10.1007/s42823-024-00838-7

Facile fabrication of CdS@GO binary nanocomposite coated GCE for separate and parallel electrochemical sensing of ascorbic acid, uric acid and nitrite

Carbon Letters
Abbr : Carbon Lett.
2025, 35(2), pp.881~893
DOI : 10.1007/s42823-024-00838-7
Publisher : Korean Carbon Society
Research Area : Natural Science > Natural Science General > Other Natural Sciences General
Received : June 1, 2024
Accepted : December 23, 2024
Published : June 5, 2025

A. Dhamodharan ¹, E. Murugan ², Huan Pang ¹, K. Perumal ³, K. Jhansirani ⁴, Yajun Gao ¹

¹Yangzhou University
²University of Madras
³Department of Physics, Science and Humanities, Jeppiaar Engineering College
⁴National Dong Hwa University

Accredited

ABSTRACT

The accurate detection of vital biomarkers such as Ascorbic Acid (AA), Uric Acid (UA) and Nitrite (NO2−) is crucial for human health surveillance. However, existing methods often struggle with concurrent detection and quantification of multiple species, highlighting the need for a more effective solution. To address this challenge, this study aimed to develop a multifunctional electrochemical sensor capable of parallel detection of AA, UA and NO2− using a synergistic combination of Graphene Oxide (GO) and Cadmium Sulfide (CdS) materials. Notably, the fabricated CdS@GO/Glassy Carbon Electrode (GCE) exhibited exceptional electrochemical activity, as evidenced by Differential Pulse Voltammetry (DPV) analysis. The sensor demonstrated remarkable sensitivity (8.13, 10.12, and 9.05 μA·μM−1·cm−2) and ultra-low detection limits (0.034, 0.062, and 0.084 µM) for AA, UA and NO2−, respectively. Furthermore, it successfully identified single molecules of each analyte in aqueous and biologic fluid samples, with recovery values comparable to those obtained using High-Performance Liquid Chromatography (HPLC) standard addition methods. The significance of this study lies in developing a novel CdS@GO/GCE sensor that enables concurrent detection and quantification of multiple vital biomarkers, offering a promising tool for human health monitoring and diagnosis.

KEYWORDS

Graphene Oxide, Cadmium Sulfide, Voltammetry, Uric Acid, Nitrite, Simultaneous sensing

Citation status

This is the result of checking the information with the same ISSN, publication year, volume, and start page between the WoS and the KCI journals. (as of 2026-07-09)

Total Citation Counts(KCI+WOS) (9) This is the number of times that the duplicate count has been removed by comparing the citation list of WoS and KCI.

* References for papers published after 2025 are currently being built.

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Carbon Letters 2025 KCI Impact Factor : 0.73 KCI-WoS Impact Factor : 6.26

Facile fabrication of CdS@GO binary nanocomposite coated GCE for separate and parallel electrochemical sensing of ascorbic acid, uric acid and nitrite

ABSTRACT

KEYWORDS

Citation status

This is the result of checking the information with the same ISSN, publication year, volume, and start page between the WoS and the KCI journals. (as of 2026-07-09)

Total Citation Counts(KCI+WOS) (9) This is the number of times that the duplicate count has been removed by comparing the citation list of WoS and KCI.

* References for papers published after 2025 are currently being built.

Carbon Letters 2025 KCI Impact Factor : 0.73 KCI-WoS Impact Factor : 6.26

Facile fabrication of CdS@GO binary nanocomposite coated GCE for separate and parallel electrochemical sensing of ascorbic acid, uric acid and nitrite

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WoS Citation Counts (9) This is the result of checking the information with the same ISSN, publication year, volume, and start page between the WoS and the KCI journals. (as of 2026-07-09)

Total Citation Counts(KCI+WOS) (9) This is the number of times that the duplicate count has been removed by comparing the citation list of WoS and KCI.

REFERENCES (67) * References for papers published after 2025 are currently being built.

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This is the result of checking the information with the same ISSN, publication year, volume, and start page between the WoS and the KCI journals. (as of 2026-07-09)

* References for papers published after 2025 are currently being built.