@article{ART003241553},
author={Bao Jiahui and Zhou Xuechun and He Xiaoyu and Tian Ning and Zhang Zhe and Peng Hui and Fu Changkui and Tian Tenghui and Zhao Yu and Jiang Yingnan and Jiang Rui and Whittaker Andrew K.},
title={Carbon nanodots derived from herbal extract ginsenoside Rg1 demonstrate highly effective inhibition against cervical carcinoma},
journal={Carbon Letters},
issn={1976-4251},
year={2025},
volume={35},
number={3},
pages={1349-1361},
doi={10.1007/s42823-025-00877-8}
TY - JOUR
AU - Bao Jiahui
AU - Zhou Xuechun
AU - He Xiaoyu
AU - Tian Ning
AU - Zhang Zhe
AU - Peng Hui
AU - Fu Changkui
AU - Tian Tenghui
AU - Zhao Yu
AU - Jiang Yingnan
AU - Jiang Rui
AU - Whittaker Andrew K.
TI - Carbon nanodots derived from herbal extract ginsenoside Rg1 demonstrate highly effective inhibition against cervical carcinoma
JO - Carbon Letters
PY - 2025
VL - 35
IS - 3
PB - Korean Carbon Society
SP - 1349
EP - 1361
SN - 1976-4251
AB - The current standard treatment regimen for patients with cervical cancer consists of a combination of radiotherapy and chemotherapy. However, the serious side effects often encountered with chemotherapy drugs greatly limits the effective doses that can be delivered, and hence the treatment of cervical cancer still faces strong challenges. In this study, carbon nanodots, nanodrugs with anti-cervical cancer activity and with negligible toxicity, were prepared from the precursor herbal extract ginsenoside Rg1. The surface of the Rg1 carbon nanodots is rich in hydrophilic functional groups, resulting in good dispersion in aqueous media and high biocompatibility. In Vitro experiments show that the Rg1 carbon nanodots have significant cytostatic and pro-apoptotic effects on HeLa cells, and could inhibit their migration and invasion. Experiments in tumor-bearing nude mice show that the Rg1 carbon nanodots could significantly inhibit tumor growth. Through qPCR validation, the Rg1 carbon nanodots were shown to enhance HeLa cell apoptosis, by regulating the expression levels of Cyto c, Caspase-9, Caspase-3, Bax, and Bcl-2, induce G2/M phase arrest by regulating CDK 1 and Cyclin B1 expression, and inhibit tumor cell migration by modulating CDH1 and β-catenin. Since the precursor Rg1 is a natural herbal extract, negligible toxic side effects were observed in nude mice. The work demonstrates that Rg1 carbon nanodots can be expected to become a potential nanomedicine against human cervical cancer with negligible toxic side effects and excellent therapeutic effects.
KW - Anti-cervical cancer;Carbon nanodots;Herbal extract;Nanomedicine;Ginsenoside Rg1
DO - 10.1007/s42823-025-00877-8
ER -
Bao Jiahui, Zhou Xuechun, He Xiaoyu, Tian Ning, Zhang Zhe, Peng Hui, Fu Changkui, Tian Tenghui, Zhao Yu, Jiang Yingnan, Jiang Rui and Whittaker Andrew K.. (2025). Carbon nanodots derived from herbal extract ginsenoside Rg1 demonstrate highly effective inhibition against cervical carcinoma. Carbon Letters, 35(3), 1349-1361.
Bao Jiahui, Zhou Xuechun, He Xiaoyu, Tian Ning, Zhang Zhe, Peng Hui, Fu Changkui, Tian Tenghui, Zhao Yu, Jiang Yingnan, Jiang Rui and Whittaker Andrew K.. 2025, "Carbon nanodots derived from herbal extract ginsenoside Rg1 demonstrate highly effective inhibition against cervical carcinoma", Carbon Letters, vol.35, no.3 pp.1349-1361. Available from: doi:10.1007/s42823-025-00877-8
Bao Jiahui, Zhou Xuechun, He Xiaoyu, Tian Ning, Zhang Zhe, Peng Hui, Fu Changkui, Tian Tenghui, Zhao Yu, Jiang Yingnan, Jiang Rui, Whittaker Andrew K. "Carbon nanodots derived from herbal extract ginsenoside Rg1 demonstrate highly effective inhibition against cervical carcinoma" Carbon Letters 35.3 pp.1349-1361 (2025) : 1349.
Bao Jiahui, Zhou Xuechun, He Xiaoyu, Tian Ning, Zhang Zhe, Peng Hui, Fu Changkui, Tian Tenghui, Zhao Yu, Jiang Yingnan, Jiang Rui, Whittaker Andrew K.. Carbon nanodots derived from herbal extract ginsenoside Rg1 demonstrate highly effective inhibition against cervical carcinoma. 2025; 35(3), 1349-1361. Available from: doi:10.1007/s42823-025-00877-8
Bao Jiahui, Zhou Xuechun, He Xiaoyu, Tian Ning, Zhang Zhe, Peng Hui, Fu Changkui, Tian Tenghui, Zhao Yu, Jiang Yingnan, Jiang Rui and Whittaker Andrew K.. "Carbon nanodots derived from herbal extract ginsenoside Rg1 demonstrate highly effective inhibition against cervical carcinoma" Carbon Letters 35, no.3 (2025) : 1349-1361.doi: 10.1007/s42823-025-00877-8
Bao Jiahui; Zhou Xuechun; He Xiaoyu; Tian Ning; Zhang Zhe; Peng Hui; Fu Changkui; Tian Tenghui; Zhao Yu; Jiang Yingnan; Jiang Rui; Whittaker Andrew K.. Carbon nanodots derived from herbal extract ginsenoside Rg1 demonstrate highly effective inhibition against cervical carcinoma. Carbon Letters, 35(3), 1349-1361. doi: 10.1007/s42823-025-00877-8
Bao Jiahui; Zhou Xuechun; He Xiaoyu; Tian Ning; Zhang Zhe; Peng Hui; Fu Changkui; Tian Tenghui; Zhao Yu; Jiang Yingnan; Jiang Rui; Whittaker Andrew K.. Carbon nanodots derived from herbal extract ginsenoside Rg1 demonstrate highly effective inhibition against cervical carcinoma. Carbon Letters. 2025; 35(3) 1349-1361. doi: 10.1007/s42823-025-00877-8
Bao Jiahui, Zhou Xuechun, He Xiaoyu, Tian Ning, Zhang Zhe, Peng Hui, Fu Changkui, Tian Tenghui, Zhao Yu, Jiang Yingnan, Jiang Rui, Whittaker Andrew K.. Carbon nanodots derived from herbal extract ginsenoside Rg1 demonstrate highly effective inhibition against cervical carcinoma. 2025; 35(3), 1349-1361. Available from: doi:10.1007/s42823-025-00877-8
Bao Jiahui, Zhou Xuechun, He Xiaoyu, Tian Ning, Zhang Zhe, Peng Hui, Fu Changkui, Tian Tenghui, Zhao Yu, Jiang Yingnan, Jiang Rui and Whittaker Andrew K.. "Carbon nanodots derived from herbal extract ginsenoside Rg1 demonstrate highly effective inhibition against cervical carcinoma" Carbon Letters 35, no.3 (2025) : 1349-1361.doi: 10.1007/s42823-025-00877-8
