@article{ART003241553},
author={Jiahui Bao and Xuechun Zhou and Xiaoyu He and Ning Tian and Zhe Zhang and Hui Peng and Changkui Fu and Tenghui Tian and Yu Zhao and Yingnan Jiang and Rui Jiang and Andrew K. Whittaker},
title={Carbon nanodots derived from herbal extract ginsenoside Rg1 demonstrate highly effective inhibition against cervical carcinoma},
journal={Carbon Letters},
issn={1976-4251},
year={2025},
volume={35},
number={3},
pages={1349-1361},
doi={10.1007/s42823-025-00877-8}
TY - JOUR
AU - Jiahui Bao
AU - Xuechun Zhou
AU - Xiaoyu He
AU - Ning Tian
AU - Zhe Zhang
AU - Hui Peng
AU - Changkui Fu
AU - Tenghui Tian
AU - Yu Zhao
AU - Yingnan Jiang
AU - Rui Jiang
AU - Andrew K. Whittaker
TI - Carbon nanodots derived from herbal extract ginsenoside Rg1 demonstrate highly effective inhibition against cervical carcinoma
JO - Carbon Letters
PY - 2025
VL - 35
IS - 3
PB - Korean Carbon Society
SP - 1349
EP - 1361
SN - 1976-4251
AB - The current standard treatment regimen for patients with cervical cancer consists of a combination of radiotherapy and chemotherapy. However, the serious side effects often encountered with chemotherapy drugs greatly limits the effective doses that can be delivered, and hence the treatment of cervical cancer still faces strong challenges. In this study, carbon nanodots, nanodrugs with anti-cervical cancer activity and with negligible toxicity, were prepared from the precursor herbal extract ginsenoside Rg1. The surface of the Rg1 carbon nanodots is rich in hydrophilic functional groups, resulting in good dispersion in aqueous media and high biocompatibility. In Vitro experiments show that the Rg1 carbon nanodots have significant cytostatic and pro-apoptotic effects on HeLa cells, and could inhibit their migration and invasion. Experiments in tumor-bearing nude mice show that the Rg1 carbon nanodots could significantly inhibit tumor growth. Through qPCR validation, the Rg1 carbon nanodots were shown to enhance HeLa cell apoptosis, by regulating the expression levels of Cyto c, Caspase-9, Caspase-3, Bax, and Bcl-2, induce G2/M phase arrest by regulating CDK 1 and Cyclin B1 expression, and inhibit tumor cell migration by modulating CDH1 and β-catenin. Since the precursor Rg1 is a natural herbal extract, negligible toxic side effects were observed in nude mice. The work demonstrates that Rg1 carbon nanodots can be expected to become a potential nanomedicine against human cervical cancer with negligible toxic side effects and excellent therapeutic effects.
KW - Anti-cervical cancer;Carbon nanodots;Herbal extract;Nanomedicine;Ginsenoside Rg1
DO - 10.1007/s42823-025-00877-8
ER -
Jiahui Bao, Xuechun Zhou, Xiaoyu He, Ning Tian, Zhe Zhang, Hui Peng, Changkui Fu, Tenghui Tian, Yu Zhao, Yingnan Jiang, Rui Jiang and Andrew K. Whittaker. (2025). Carbon nanodots derived from herbal extract ginsenoside Rg1 demonstrate highly effective inhibition against cervical carcinoma. Carbon Letters, 35(3), 1349-1361.
Jiahui Bao, Xuechun Zhou, Xiaoyu He, Ning Tian, Zhe Zhang, Hui Peng, Changkui Fu, Tenghui Tian, Yu Zhao, Yingnan Jiang, Rui Jiang and Andrew K. Whittaker. 2025, "Carbon nanodots derived from herbal extract ginsenoside Rg1 demonstrate highly effective inhibition against cervical carcinoma", Carbon Letters, vol.35, no.3 pp.1349-1361. Available from: doi:10.1007/s42823-025-00877-8
Jiahui Bao, Xuechun Zhou, Xiaoyu He, Ning Tian, Zhe Zhang, Hui Peng, Changkui Fu, Tenghui Tian, Yu Zhao, Yingnan Jiang, Rui Jiang, Andrew K. Whittaker "Carbon nanodots derived from herbal extract ginsenoside Rg1 demonstrate highly effective inhibition against cervical carcinoma" Carbon Letters 35.3 pp.1349-1361 (2025) : 1349.
Jiahui Bao, Xuechun Zhou, Xiaoyu He, Ning Tian, Zhe Zhang, Hui Peng, Changkui Fu, Tenghui Tian, Yu Zhao, Yingnan Jiang, Rui Jiang, Andrew K. Whittaker. Carbon nanodots derived from herbal extract ginsenoside Rg1 demonstrate highly effective inhibition against cervical carcinoma. 2025; 35(3), 1349-1361. Available from: doi:10.1007/s42823-025-00877-8
Jiahui Bao, Xuechun Zhou, Xiaoyu He, Ning Tian, Zhe Zhang, Hui Peng, Changkui Fu, Tenghui Tian, Yu Zhao, Yingnan Jiang, Rui Jiang and Andrew K. Whittaker. "Carbon nanodots derived from herbal extract ginsenoside Rg1 demonstrate highly effective inhibition against cervical carcinoma" Carbon Letters 35, no.3 (2025) : 1349-1361.doi: 10.1007/s42823-025-00877-8
Jiahui Bao; Xuechun Zhou; Xiaoyu He; Ning Tian; Zhe Zhang; Hui Peng; Changkui Fu; Tenghui Tian; Yu Zhao; Yingnan Jiang; Rui Jiang; Andrew K. Whittaker. Carbon nanodots derived from herbal extract ginsenoside Rg1 demonstrate highly effective inhibition against cervical carcinoma. Carbon Letters, 35(3), 1349-1361. doi: 10.1007/s42823-025-00877-8
Jiahui Bao; Xuechun Zhou; Xiaoyu He; Ning Tian; Zhe Zhang; Hui Peng; Changkui Fu; Tenghui Tian; Yu Zhao; Yingnan Jiang; Rui Jiang; Andrew K. Whittaker. Carbon nanodots derived from herbal extract ginsenoside Rg1 demonstrate highly effective inhibition against cervical carcinoma. Carbon Letters. 2025; 35(3) 1349-1361. doi: 10.1007/s42823-025-00877-8
Jiahui Bao, Xuechun Zhou, Xiaoyu He, Ning Tian, Zhe Zhang, Hui Peng, Changkui Fu, Tenghui Tian, Yu Zhao, Yingnan Jiang, Rui Jiang, Andrew K. Whittaker. Carbon nanodots derived from herbal extract ginsenoside Rg1 demonstrate highly effective inhibition against cervical carcinoma. 2025; 35(3), 1349-1361. Available from: doi:10.1007/s42823-025-00877-8
Jiahui Bao, Xuechun Zhou, Xiaoyu He, Ning Tian, Zhe Zhang, Hui Peng, Changkui Fu, Tenghui Tian, Yu Zhao, Yingnan Jiang, Rui Jiang and Andrew K. Whittaker. "Carbon nanodots derived from herbal extract ginsenoside Rg1 demonstrate highly effective inhibition against cervical carcinoma" Carbon Letters 35, no.3 (2025) : 1349-1361.doi: 10.1007/s42823-025-00877-8
