@article{ART003241589},
author={Bin‑Hao Liu and Long‑Yue Meng and Lian‑Hua Han and Biao Jin},
title={Ultra-high sensitivity electrochemical aptamer biosensor based on a carbon nano-confined interface for the detection of aflatoxin B1 in traditional chinese materia medica decoction pieces},
journal={Carbon Letters},
issn={1976-4251},
year={2025},
volume={35},
number={3},
pages={1461-1472},
doi={10.1007/s42823-025-00886-7}
TY - JOUR
AU - Bin‑Hao Liu
AU - Long‑Yue Meng
AU - Lian‑Hua Han
AU - Biao Jin
TI - Ultra-high sensitivity electrochemical aptamer biosensor based on a carbon nano-confined interface for the detection of aflatoxin B1 in traditional chinese materia medica decoction pieces
JO - Carbon Letters
PY - 2025
VL - 35
IS - 3
PB - Korean Carbon Society
SP - 1461
EP - 1472
SN - 1976-4251
AB - A novel, ultra-high sensitivity electrochemical aptamer biosensor (EAB) was fabricated by immobilising gold nanoparticles (Au) on a nano-confined interface of N-doped carbon nanofibers/carbon fibers (N-CNFs/CFs). Gold nanoparticle-thiol (Au–S) conjugates, coupled with aptamer-specific recognition technology, were used to immobilise aflatoxin B1 (AFB1). The nano-confined interface of N-CNFs/CFs provides more binding sites for Au with its unique spatial structure and electroactive surface area, enhancing the electrochemical performance of the matrix. Compared to the existing sensor detection limit, the limit of detection(LOD) of the EAB was approximately 6.4 pg/mL. The dynamic detection ranged from 10.0 to 1.0 × 108 pg/mL. Furthermore, AFB1 was also successfully detected in Chinese Materia Medica decoction pieces(CMMDP) using the prepared EAB, with recoveries ranging from 96.18 to 112.87%. These results demonstrate the proposed EAB’s potential as a reliable tool for rapid and efficient detection of AFB1 in complex matrices.
KW - Nano-confined interface;Aflatoxin B1;Carbon nanofibers;Electrochemical aptamer biosensor;Sensitive detection;Chinese materia medica decoction pieces
DO - 10.1007/s42823-025-00886-7
ER -
Bin‑Hao Liu, Long‑Yue Meng, Lian‑Hua Han and Biao Jin. (2025). Ultra-high sensitivity electrochemical aptamer biosensor based on a carbon nano-confined interface for the detection of aflatoxin B1 in traditional chinese materia medica decoction pieces. Carbon Letters, 35(3), 1461-1472.
Bin‑Hao Liu, Long‑Yue Meng, Lian‑Hua Han and Biao Jin. 2025, "Ultra-high sensitivity electrochemical aptamer biosensor based on a carbon nano-confined interface for the detection of aflatoxin B1 in traditional chinese materia medica decoction pieces", Carbon Letters, vol.35, no.3 pp.1461-1472. Available from: doi:10.1007/s42823-025-00886-7
Bin‑Hao Liu, Long‑Yue Meng, Lian‑Hua Han, Biao Jin "Ultra-high sensitivity electrochemical aptamer biosensor based on a carbon nano-confined interface for the detection of aflatoxin B1 in traditional chinese materia medica decoction pieces" Carbon Letters 35.3 pp.1461-1472 (2025) : 1461.
Bin‑Hao Liu, Long‑Yue Meng, Lian‑Hua Han, Biao Jin. Ultra-high sensitivity electrochemical aptamer biosensor based on a carbon nano-confined interface for the detection of aflatoxin B1 in traditional chinese materia medica decoction pieces. 2025; 35(3), 1461-1472. Available from: doi:10.1007/s42823-025-00886-7
Bin‑Hao Liu, Long‑Yue Meng, Lian‑Hua Han and Biao Jin. "Ultra-high sensitivity electrochemical aptamer biosensor based on a carbon nano-confined interface for the detection of aflatoxin B1 in traditional chinese materia medica decoction pieces" Carbon Letters 35, no.3 (2025) : 1461-1472.doi: 10.1007/s42823-025-00886-7
Bin‑Hao Liu; Long‑Yue Meng; Lian‑Hua Han; Biao Jin. Ultra-high sensitivity electrochemical aptamer biosensor based on a carbon nano-confined interface for the detection of aflatoxin B1 in traditional chinese materia medica decoction pieces. Carbon Letters, 35(3), 1461-1472. doi: 10.1007/s42823-025-00886-7
Bin‑Hao Liu; Long‑Yue Meng; Lian‑Hua Han; Biao Jin. Ultra-high sensitivity electrochemical aptamer biosensor based on a carbon nano-confined interface for the detection of aflatoxin B1 in traditional chinese materia medica decoction pieces. Carbon Letters. 2025; 35(3) 1461-1472. doi: 10.1007/s42823-025-00886-7
Bin‑Hao Liu, Long‑Yue Meng, Lian‑Hua Han, Biao Jin. Ultra-high sensitivity electrochemical aptamer biosensor based on a carbon nano-confined interface for the detection of aflatoxin B1 in traditional chinese materia medica decoction pieces. 2025; 35(3), 1461-1472. Available from: doi:10.1007/s42823-025-00886-7
Bin‑Hao Liu, Long‑Yue Meng, Lian‑Hua Han and Biao Jin. "Ultra-high sensitivity electrochemical aptamer biosensor based on a carbon nano-confined interface for the detection of aflatoxin B1 in traditional chinese materia medica decoction pieces" Carbon Letters 35, no.3 (2025) : 1461-1472.doi: 10.1007/s42823-025-00886-7
