@article{ART003341994},
author={Zhang Yuling and Zhao Zhihao and Chen Yanbing and Zhang Jiaru and Su Xiao and Meng Lanxin and Xie Zhenzhen and Liu Zhiyong and Sun Shiguo},
title={Synthesis and antitumor efficacy of biodegradable hollow mesoporous carbon nanocarriers},
journal={Carbon Letters},
issn={1976-4251},
year={2026},
volume={36},
number={1},
pages={423-440},
doi={10.1007/s42823-025-00995-3}
TY - JOUR
AU - Zhang Yuling
AU - Zhao Zhihao
AU - Chen Yanbing
AU - Zhang Jiaru
AU - Su Xiao
AU - Meng Lanxin
AU - Xie Zhenzhen
AU - Liu Zhiyong
AU - Sun Shiguo
TI - Synthesis and antitumor efficacy of biodegradable hollow mesoporous carbon nanocarriers
JO - Carbon Letters
PY - 2026
VL - 36
IS - 1
PB - Korean Carbon Society
SP - 423
EP - 440
SN - 1976-4251
AB - The inherent non-degradation and potential toxicity of pure carbon nanomaterials in vivo remain the main obstacles to clinical translation. This study attempts to prepare a novel biodegradable caramelized hollow mesoporous carbon nanospheres (CHMCNs) with mesoporous shells and a large cavity, which can be decomposed into small particles (~ 5 nm) within 7 days under physiological conditions. By varying the synthesis parameters and templates, CHMCNs with different morphologies can be obtained to meet different application requirements. Meanwhile, CHMCNs exhibit excellent biocompatibility and high drug-loading efficiency, enabling effective delivery of anticancer drugs (DOX) into cells. In addition, due to the good photothermal efficiency (PTT, 29.7%), CHMCNs facilitate pH/NIR dual-responsive drug release under NIR irradiation, resulting in an excellent synergistic chemo-photothermal therapy effect. The results indicate that CHMCNs is a promising drug delivery carrier. In conclusion, this work addresses the non-degradable defects of traditional mesoporous carbon nanomaterials (MCN) and proposes a novel nanocarrier system for tumor treatment.
KW - Biodegradable Hollow mesoporous carbon nanomaterials Drug carrier Biocompatibility Synergistic therapy
DO - 10.1007/s42823-025-00995-3
ER -
Zhang Yuling, Zhao Zhihao, Chen Yanbing, Zhang Jiaru, Su Xiao, Meng Lanxin, Xie Zhenzhen, Liu Zhiyong and Sun Shiguo. (2026). Synthesis and antitumor efficacy of biodegradable hollow mesoporous carbon nanocarriers. Carbon Letters, 36(1), 423-440.
Zhang Yuling, Zhao Zhihao, Chen Yanbing, Zhang Jiaru, Su Xiao, Meng Lanxin, Xie Zhenzhen, Liu Zhiyong and Sun Shiguo. 2026, "Synthesis and antitumor efficacy of biodegradable hollow mesoporous carbon nanocarriers", Carbon Letters, vol.36, no.1 pp.423-440. Available from: doi:10.1007/s42823-025-00995-3
Zhang Yuling, Zhao Zhihao, Chen Yanbing, Zhang Jiaru, Su Xiao, Meng Lanxin, Xie Zhenzhen, Liu Zhiyong, Sun Shiguo "Synthesis and antitumor efficacy of biodegradable hollow mesoporous carbon nanocarriers" Carbon Letters 36.1 pp.423-440 (2026) : 423.
Zhang Yuling, Zhao Zhihao, Chen Yanbing, Zhang Jiaru, Su Xiao, Meng Lanxin, Xie Zhenzhen, Liu Zhiyong, Sun Shiguo. Synthesis and antitumor efficacy of biodegradable hollow mesoporous carbon nanocarriers. 2026; 36(1), 423-440. Available from: doi:10.1007/s42823-025-00995-3
Zhang Yuling, Zhao Zhihao, Chen Yanbing, Zhang Jiaru, Su Xiao, Meng Lanxin, Xie Zhenzhen, Liu Zhiyong and Sun Shiguo. "Synthesis and antitumor efficacy of biodegradable hollow mesoporous carbon nanocarriers" Carbon Letters 36, no.1 (2026) : 423-440.doi: 10.1007/s42823-025-00995-3
Zhang Yuling; Zhao Zhihao; Chen Yanbing; Zhang Jiaru; Su Xiao; Meng Lanxin; Xie Zhenzhen; Liu Zhiyong; Sun Shiguo. Synthesis and antitumor efficacy of biodegradable hollow mesoporous carbon nanocarriers. Carbon Letters, 36(1), 423-440. doi: 10.1007/s42823-025-00995-3
Zhang Yuling; Zhao Zhihao; Chen Yanbing; Zhang Jiaru; Su Xiao; Meng Lanxin; Xie Zhenzhen; Liu Zhiyong; Sun Shiguo. Synthesis and antitumor efficacy of biodegradable hollow mesoporous carbon nanocarriers. Carbon Letters. 2026; 36(1) 423-440. doi: 10.1007/s42823-025-00995-3
Zhang Yuling, Zhao Zhihao, Chen Yanbing, Zhang Jiaru, Su Xiao, Meng Lanxin, Xie Zhenzhen, Liu Zhiyong, Sun Shiguo. Synthesis and antitumor efficacy of biodegradable hollow mesoporous carbon nanocarriers. 2026; 36(1), 423-440. Available from: doi:10.1007/s42823-025-00995-3
Zhang Yuling, Zhao Zhihao, Chen Yanbing, Zhang Jiaru, Su Xiao, Meng Lanxin, Xie Zhenzhen, Liu Zhiyong and Sun Shiguo. "Synthesis and antitumor efficacy of biodegradable hollow mesoporous carbon nanocarriers" Carbon Letters 36, no.1 (2026) : 423-440.doi: 10.1007/s42823-025-00995-3
