@article{ART003387376},
author={Kim Seongjin and Kim Hamin and Lee Seungae},
title={Carbon-based biodegradable composite microspheres enabling magnetic–thermal coupling for chemoembolization},
journal={Carbon Letters},
issn={1976-4251},
year={2026},
volume={36},
number={3},
pages={1299-1310},
doi={10.1007/s42823-026-01063-0}
TY - JOUR
AU - Kim Seongjin
AU - Kim Hamin
AU - Lee Seungae
TI - Carbon-based biodegradable composite microspheres enabling magnetic–thermal coupling for chemoembolization
JO - Carbon Letters
PY - 2026
VL - 36
IS - 3
PB - Korean Carbon Society
SP - 1299
EP - 1310
SN - 1976-4251
AB - Carbon-containing polymer composites integrated with metal oxide nanoparticles offer opportunities to regulate thermal and magnetic responses through interfacial interactions. This study develops Fe3O4/polycaprolactone (PCL) composite microspheres constructed from a carbon-containing biodegradable matrix, enabling magnetically guided chemoembolization and hyperthermia. The microspheres are fabricated via a water-in-oil-in-water emulsion method, resulting in a controlled size distribution (350–550 μm) suitable for embolization. Fe3O4 nanoparticles are incorporated to confer magnetic responsiveness and photothermal activity, while the carbon-rich polymer matrix (PCL) provides biodegradability and cost-effectiveness. Comprehensive physicochemical characterization confirms the successful integration of Fe3O4 and homogeneous morphology of the microspheres. The resulting microspheres exhibit adequate magnetization (6.6 emu g− 1), photothermal heating capability under near-infrared laser irradiation (ΔT = 4.5 °C at 50 mg mL− 1) and dose-dependent embolization behavior in a phantom model. Drug release experiments reveal a biphasic release profile, with an initial burst release (cumulative release of ~ 13% within 3 h), followed by sustained release reaching approximately 19%. Thermal analysis revealed a narrowing of the derivative thermogravimetry (DTG) peak relative to neat PCL, suggesting synchronized degradation behavior associated with carbon–metal oxide interfacial interaction. These findings demonstrate that Fe3O4/PCL composite system exhibits coordinated magnetic–thermal functionality governed by the carbon-containing polymer matrix and its interfacial interaction with iron oxide nanoparticles.
KW - Organic carbon matrix Polycaprolactone Iron oxide composite Magnetic hyperthermia
DO - 10.1007/s42823-026-01063-0
ER -
Kim Seongjin, Kim Hamin and Lee Seungae. (2026). Carbon-based biodegradable composite microspheres enabling magnetic–thermal coupling for chemoembolization. Carbon Letters, 36(3), 1299-1310.
Kim Seongjin, Kim Hamin and Lee Seungae. 2026, "Carbon-based biodegradable composite microspheres enabling magnetic–thermal coupling for chemoembolization", Carbon Letters, vol.36, no.3 pp.1299-1310. Available from: doi:10.1007/s42823-026-01063-0
Kim Seongjin, Kim Hamin, Lee Seungae "Carbon-based biodegradable composite microspheres enabling magnetic–thermal coupling for chemoembolization" Carbon Letters 36.3 pp.1299-1310 (2026) : 1299.
Kim Seongjin, Kim Hamin, Lee Seungae. Carbon-based biodegradable composite microspheres enabling magnetic–thermal coupling for chemoembolization. 2026; 36(3), 1299-1310. Available from: doi:10.1007/s42823-026-01063-0
Kim Seongjin, Kim Hamin and Lee Seungae. "Carbon-based biodegradable composite microspheres enabling magnetic–thermal coupling for chemoembolization" Carbon Letters 36, no.3 (2026) : 1299-1310.doi: 10.1007/s42823-026-01063-0
Kim Seongjin; Kim Hamin; Lee Seungae. Carbon-based biodegradable composite microspheres enabling magnetic–thermal coupling for chemoembolization. Carbon Letters, 36(3), 1299-1310. doi: 10.1007/s42823-026-01063-0
Kim Seongjin; Kim Hamin; Lee Seungae. Carbon-based biodegradable composite microspheres enabling magnetic–thermal coupling for chemoembolization. Carbon Letters. 2026; 36(3) 1299-1310. doi: 10.1007/s42823-026-01063-0
Kim Seongjin, Kim Hamin, Lee Seungae. Carbon-based biodegradable composite microspheres enabling magnetic–thermal coupling for chemoembolization. 2026; 36(3), 1299-1310. Available from: doi:10.1007/s42823-026-01063-0
Kim Seongjin, Kim Hamin and Lee Seungae. "Carbon-based biodegradable composite microspheres enabling magnetic–thermal coupling for chemoembolization" Carbon Letters 36, no.3 (2026) : 1299-1310.doi: 10.1007/s42823-026-01063-0
