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@article{ART002164256},
author={김민호 and 정현석 and 박명덕 and Moon Phil-Dong},
title={Effect of KH-BaRoKer-SeongJangTang based on traditional medicine theory on longitudinal bone growth},
journal={CELLMED},
issn={3022-6805},
year={2014},
volume={4},
number={2},
pages={14-14},
doi={10.5667/tang.2014.0020}

TY - JOUR
AU - 김민호
AU - 정현석
AU - 박명덕
AU - Moon Phil-Dong
TI - Effect of KH-BaRoKer-SeongJangTang based on traditional medicine theory on longitudinal bone growth
JO - CELLMED
PY - 2014
VL - 4
IS - 2
PB - Cellmed Orthocellular Medicine and Pharmaceutical Association
SP - 14
EP - 14
SN - 3022-6805
AB - KH-BaRoKer-SeongJangTang (KBS) is a recently developed formulation by using traditional drugs considering traditional medical theory of Oriental books such as ShinNongBonChoGyeong and JuRye, which has been used to improve the growth of child in Korea. Although KBS is usually prescribed to many children who are in retard for their age, its pharmacological effects have not been fully understood in experimental models. The aim of this study was to evaluate the effects of KBS on bone growth. Growth plate thickness and bone parameters such as bone volume/tissue volume (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), connection density (Conn.D), and total porosity were analyzed by means of microcomputed tomography. Serum insulin-like growth factor-I (IGF-I) levels were measured by enzyme-linked immunosorbent assay. Hepatic IGF-I mRNA expression was analyzed by real-time polymerase chain reaction. Phosphorylation of signal transducer and activator of transcription5 (STAT5) was investigated using Western blot analysis and immunohistochemistry. The thickness of growth plate was increased by KBS. BV/TV, Tb.Th, TbN, Conn.D, and total porosity were improved by KBS. Hepatic IGF-I mRNA and serum IGF-I levels were elevated by KBS. Phosphorylation of STAT5 was increased with administration of KBS. These results suggest that KBS would be helpful to children who are in retard for their age through the elevation of IGF-I.
KW - growth plate;bone parameters;insulin-like growth factor-I;signal transducer and activator of transcription5
DO - 10.5667/tang.2014.0020
ER -

김민호, 정현석, 박명덕 and Moon Phil-Dong. (2014). Effect of KH-BaRoKer-SeongJangTang based on traditional medicine theory on longitudinal bone growth. CELLMED, 4(2), 14-14.

김민호, 정현석, 박명덕 and Moon Phil-Dong. 2014, "Effect of KH-BaRoKer-SeongJangTang based on traditional medicine theory on longitudinal bone growth", CELLMED, vol.4, no.2 pp.14-14. Available from: doi:10.5667/tang.2014.0020

김민호, 정현석, 박명덕, Moon Phil-Dong "Effect of KH-BaRoKer-SeongJangTang based on traditional medicine theory on longitudinal bone growth" CELLMED 4.2 pp.14-14 (2014) : 14.

김민호, 정현석, 박명덕, Moon Phil-Dong. Effect of KH-BaRoKer-SeongJangTang based on traditional medicine theory on longitudinal bone growth. 2014; 4(2), 14-14. Available from: doi:10.5667/tang.2014.0020

김민호, 정현석, 박명덕 and Moon Phil-Dong. "Effect of KH-BaRoKer-SeongJangTang based on traditional medicine theory on longitudinal bone growth" CELLMED 4, no.2 (2014) : 14-14.doi: 10.5667/tang.2014.0020

김민호; 정현석; 박명덕; Moon Phil-Dong. Effect of KH-BaRoKer-SeongJangTang based on traditional medicine theory on longitudinal bone growth. CELLMED, 4(2), 14-14. doi: 10.5667/tang.2014.0020

김민호; 정현석; 박명덕; Moon Phil-Dong. Effect of KH-BaRoKer-SeongJangTang based on traditional medicine theory on longitudinal bone growth. CELLMED. 2014; 4(2) 14-14. doi: 10.5667/tang.2014.0020

김민호, 정현석, 박명덕, Moon Phil-Dong. Effect of KH-BaRoKer-SeongJangTang based on traditional medicine theory on longitudinal bone growth. 2014; 4(2), 14-14. Available from: doi:10.5667/tang.2014.0020

김민호, 정현석, 박명덕 and Moon Phil-Dong. "Effect of KH-BaRoKer-SeongJangTang based on traditional medicine theory on longitudinal bone growth" CELLMED 4, no.2 (2014) : 14-14.doi: 10.5667/tang.2014.0020