CELLMED 2023 KCI Impact Factor : 0.03
-
pISSN : 3022-6805 / eISSN : 3022-6791
- https://journal.kci.go.kr/cellmed
KJCKorea
Journal Central
Biological effects of zinc oxide nanoparticles on inflammation
- CELLMED
- Abbr : CellMed
- 2016, 6(4), pp.23-23
- DOI : 10.5667/tang.2016.0013
- Publisher : Cellmed Orthocellular Medicine and Pharmaceutical Association
- Research Area : Medicine and Pharmacy > General Medicine
1서해대학
Candidate
ABSTRACT
With the rapid developments in nanotechnology, an increasing number of nanomaterials have been applied in various aspects of our lives. Recently, pharmaceutical nanotechnology with numerous advantages has growingly attracted the attention of many researchers. Zinc oxide nanoparticles (ZnO-NPs) are nanomaterials that are widely used in many fields including diagnostics, therapeutics, drug-delivery systems, electronics, cosmetics, sunscreens, coatings, ceramic products, paints, and food additives, due to their magnetic, catalytic, semiconducting, anti-cancer, anti-bacterial, anti-inflammatory, ultraviolet-protective, and binding properties. The present review focused on the recent research works concerning role of ZnO-NP on inflammation. Several studies have reported that ZnO-NP induces inflammatory reaction through the generation of reactive oxygen species by oxidative stress and production of inflammatory cytokines by activation of nuclear factor-κB (NF-B). Meanwhile, other researchers reported that ZnO-NP exhibits an anti-inflammatory effect by inhibiting the up-regulation of inflammatory cytokines and the activation of NF-κB, caspase-1, IκB kinaseβ, receptor interacting protein2, and extracellular signal-regulated kinase. Previous studies reported that size and shape of nanoparticles, surfactants used for nanoparticles protection, medium, and experimental conditions can also affect cellular signal pathway. This review indicated that the anti-inflammatory effectiveness of ZnO-NP was determined by the nanoparticle size as well as various experimental conditions. Therefore, the author suggests that pharmaceutical therapy with the ZnO-NP is one of the possible strategies to overcome the inflammatory reactions. However, further studies should be performed to maximize the anti-inflammatory effect of ZnO-NP to apply as a potential agent in biomedical applications.
Statistics
-
348 Viewed
-
49 Downloaded
Tools
Issue List
Citation status
* References for papers published after 2023 are currently being built.
[journal]
Andoh T
/ 1998
/ Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice
/ J Pharmacol Exp Ther
286
: 1140~1145
[journal]
Babin K
/ 2015
/ Nanoparticles enhance the ability of human neutrophils to exert phagocytosis by a Sykdependent mechanism
/ Biochim Biophys Acta
1850
: 2276~2282
[journal]
Barton GM
/ 2008
/ A calculated response : control of inflammation by the innate immune system
/ J Clin Invest
118
: 413~420
[journal]
Chang H
/ 2013
/ Involvement of MyD88 in zinc oxide nanoparticle-induced lung inflammation
/ Exp Toxicol Pathol
65
: 887~896
[journal]
Chiang HM
/ 2012
/ Nanoscale ZnO induces cytotoxicity and DNA damage in human cell lines and rat primary neuronal cells
/ J Nanosci Nanotechnol
12
: 2126~2135
[journal]
Contado C
/ 2015
/ Nanomaterials in consumer products : a challenging analytical problem
/ Front Chem
3
: 48~
[journal]
Dizaj SM
/ 2014
/ Antimicrobial activity of the metals and metal oxide nanoparticles
/ Mater Sci Eng C Mater Biol Appl
44
: 278~284
[journal]
Frederickson CJ
/ 1988
/ Loss of zinc staining from hippocampal mossy fibers during kainic acid induced seizures : a histofluorescence study
/ Brain Res
446
: 383~386
[journal]
Frederickson CJ
/ 2005
/ The neurobiology of zinc in health and disease
/ Nat Rev Neurosci
6
: 449~462
[journal]
Fukui H
/ 2015
/ Ascorbic acid attenuates acute pulmonary oxidative stress and inflammation caused by zinc oxide nanoparticles
/ J Occup Health
57
: 118~125
[journal]
Giovanni M
/ 2015
/ Proinflammatory responses of RAW264.7 macrophages when treated with ultralow concentrations of silver, titanium dioxide, and zinc oxide nanoparticles
/ J Hazard Mater
297
: 146~152
[journal]
Hackenberg S
/ 2011
/ Cytotoxic, genotoxic and pro-inflammatory effects of zinc oxide nanoparticles in human nasal mucosa cells in vitro
/ Toxicol In Vitro
25
: 657~663
[journal]
Harhaj EW
/ 2011
/ Deubiquitinases in the regulation of NF-κB signaling
/ Cell Res
21
: 22~39
[journal]
Higgs GA
/ 1984
/ Eicosanoids in inflammation
/ Ann Clin Res
16
: 287~299
[journal]
Horie M
/ 2015
/ Pharyngeal aspiration of metal oxide nanoparticles showed potential of allergy aggravation effect to inhaled ovalbumin
/ Inhal Toxicol
27
: 181~190
[journal]
Huang KL
/ 2015
/ Zinc oxide nanoparticles induce eosinophilic airway inflammation in mice
/ J Hazard Mater
297
: 304~312
[journal]
Ilves M
/ 2014
/ Topically applied ZnO nanoparticles suppress allergen induced skin inflammation but induce vigorous IgE production in the atopic dermatitis mouse model
/ Part Fibre Toxicol
11
: 38~
[journal]
Jansen J
/ 2009
/ Zinc and diabetes--clinical links and molecular mechanisms
/ J Nutr Biochem
20
: 399~417
[journal]
Jeong HJ
/ 2002
/ Inhibition of TNF-alpha and IL-6production by Aucubin through blockade of NF-kappaB activation RBL-2H3 mast cells
/ Cytokine
18
: 252~259
[journal]
Jeong SH
/ 2013
/ ZnO nanoparticles induce TNF-α expression via ROS-ERK-Egr-1 pathway in human keratinocytes
/ J Dermatol Sci
72
: 263~273
[journal]
Kim MH
/ 2016
/ Zinc oxide nanoparticels demoted MDM2expression to suppress TSLP-induced mast cell proliferation
/ J Nanosci Nanotechnol
16
: 2492~2498
[journal]
Kim MH
/ 2015
/ Zinc Oxide Nanoparticles Suppress LPSInduced NF-κB Activation by Inducing A20, a Negative Regulator of NF-κB, in RAW 264.7 Macrophages
/ J Nanosci Nanotechnol
15
: 6509~6515
[journal]
Kim MH
/ 2014
/ Zinc oxide nanoparticles, a novel candidate for the treatment of allergic inflammatory diseases
/ Eur J Pharmacol
738
: 31~39
[journal]
Kumar R
/ 2004
/ The dynamics of acute inflammation
/ J Theor Biol
230
: 145~155
[book]
Kumar V
/ 2003
/ Robbins Basic Pathology
/ Saunders
[journal]
Kwon DJ
/ 2013
/ Suppression of iNOS and COX-2 expression by flavokawain A via blockade of NF-κB and AP-1 activation in RAW 264.7 macrophages
/ Food Chem Toxicol
58
: 479~486
[journal]
Li CH
/ 2012
/ Zinc oxide nanoparticles-induced intercellular adhesion molecule 1 expression requires Rac1/Cdc42, mixed lineage kinase 3, and c-Jun N-terminal kinase activation in endothelial cells
/ Toxicol Sci
126
: 162~172
[journal]
Liu J
/ 2016
/ The toxicology of ion-shedding zinc oxide nanoparticles
/ Crit Rev Toxicol
46
: 348~384
[book]
Majno G
/ 2004
/ Cells, Tissues, and Disease
/ Oxford University Press
[journal]
Maremanda KP
/ 2014
/ Zinc protects cyclophosphamide-induced testicular damage in rat : Involvement of metallothionein, tesmin and Nrf2
/ Biochem Biophys Res Commun
445
: 591~596
[journal]
Medzhitov R
/ 2008
/ Origin and physiological roles of inflammation
/ Nature
454(24)
: 428~435
[journal]
Nakanishi W
/ 2014
/ Bioactive nanocarbon assemblies : Nanoarchitectonics and applications
/ Nano Today
9
: 378~394
[journal]
Pati R
/ 2014
/ Topical application of zinc oxide nanoparticles reduces bacterial skin infection in mice and exhibits antibacterial activity by inducing oxidative stress response and cell membrane disintegration in macrophages
/ Nanomedicine
10
: 1195~1208
[journal]
Perkins ND
/ 2007
/ Integrating cell-signalling pathways with NF-κB and IKK function
/ Nat Rev Mol Cell Biol
8
: 49~62
[journal]
Roy R
/ 2014
/ Zinc oxide nanoparticles provide an adjuvant effect to ovalbumin via a Th2 response in Balb/c mice
/ Int Immunol
26
: 159~172
[journal]
Roy R
/ 2013
/ Mechanism of uptake of ZnO nanoparticles and inflammatory responses in macrophages require PI3K mediated MAPKs signaling
/ Toxicol In Vitro
28
: 457~467
[journal]
Roy R
/ 2014
/ Mechanism of uptake of ZnO nanoparticles and inflammatory responses in macrophages require PI3K mediated MAPKs signaling
/ Toxicol In Vitro
28
: 457~467
[journal]
Seabra AB
/ 2013
/ Biogenic synthesis of nanostructured iron compounds : applications and perspectives
/ IET Nanobiotechnol
7
: 90~99
[journal]
Senapati VA
/ 2015
/ ZnO nanoparticles induced inflammatory response and genotoxicity in human blood cells : A mechanistic approach
/ Food Chem Toxicol
85
: 61~70
[journal]
Shapiro SD
/ 1991
/ Elastin degradation by mononuclear phagocytes
/ Ann N Y Acad Sci
624
: 69~80
[journal]
Sharma V
/ 2012
/ Induction of oxidative stress, DNA damage and apoptosis in mouse liver after sub-acute oral exposure to zinc oxide nanoparticles
/ Mutat Res
745
: 84~91
[journal]
Shembade N
/ 2010
/ Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes
/ Science
327
: 1135~1139
[journal]
Skjøt-Arkil H
/ 2010
/ Macrophage-mediated proteolytic remodeling of the extracellular matrix in atherosclerosis results in neoepitopes : a potential new class of biochemical markers
/ Assay Drug Dev Technol
8
: 542~552
[journal]
Song YH
/ 2002
/ Socioeconomic impact traditional Korean medicine, Pyeongwee-San (KMP6) as an anti-allergic inflammatory drug
/ TANG
2
: e29~
[journal]
Spencer LA
/ 2009
/ Human eosinophils constitutively express multiple Th1, Th2, and immunoregulatory cytokines that are secreted rapidly and differentially
/ J Leukoc Biol
85
: 117~123
[journal]
Stoehr LC
/ 2015
/ Assessment of a panel of interleukin-8reporter lung epithelial cell lines to monitor the proinflammatory response following zinc oxide nanoparticle exposure under different cell culture conditions
/ Part Fibre Toxicol
12
: 29~
[journal]
Stone SF
/ 2013
/ Immune response to snake envenoming and treatment with antivenom; complement activation, cytokine production and mast cell degranulation
/ PLoS Negl Trop Dis
7
: e2326~
[book]
Taniguchi N
/ 1974
/ Proceedings of the International Conference on Production Engineering, Tokyo, PartII
/ Japan Society of Precision Engineering
[journal]
Tornatore L
/ 2012
/ The nuclear factor kappa B signaling pathway : integrating metabolism with inflammation
/ Trends Cell Biol
22
: 557~566
[journal]
Tsou TC
/ 2010
/ Zinc oxide particles induce inflammatory responses in vascular endothelial cells via NF-κB signaling
/ J Hazard Mater
183
: 182~188
[journal]
Wahab R
/ 2010
/ Formation of ZnO Micro-Flowers Prepared via Solution Process and their Antibacterial Activity
/ Nanoscale Res Lett
5
: 1675~1681
[journal]
Wahab R
/ 2014
/ ZnO nanoparticles induced oxidative stress and apoptosis in HepG2 and MCF-7cancer cell and their antibacterial activity
/ Colloids Surf B Biointerfaces
117
: 267~276
[journal]
Whatmore RW
/ 2006
/ Nanotechnology--what is it? Should we be worried?
/ Occupational Medicine
56
: 295~299