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@article{ART002175809},
author={오현아 and 류재규 and Wung-Seok Cha and Hyung-Min Kim and 정현자},
title={Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model},
journal={CELLMED},
issn={3022-6805},
year={2012},
volume={2},
number={1},
pages={9-9}

TY - JOUR
AU - 오현아
AU - 류재규
AU - Wung-Seok Cha
AU - Hyung-Min Kim
AU - 정현자
TI - Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model
JO - CELLMED
PY - 2012
VL - 2
IS - 1
PB - Cellmed Orthocellular Medicine and Pharmaceutical Association
SP - 9
EP - 9
SN - 3022-6805
AB - Jeechool-Whan (JW) is a prescription of Ponciri Fructus Immaturus and Atractylodis Rhizoma Alba and improves the functions of the stomach and the spleen. Although it is said in Korean Medicine that the spleen and the stomach are the roots of the body's resistance, the meaning of 'improving the spleen and the stomach' is very comprehensive. Moreover, there are lots of drugs that are said to improve the spleen and the stomach, and the number of prescriptions using these drugs is huge. In this study, we focused on the new effect and mechanism of the JW on the ovalbumin (OVA)-induced allergic rhinitis (AR) model. The increased number of rubs and the increased levels of IgE and histamine in the OVA-sensitized mice were inhibited by JW administration. The balance of Th1/Th2 cytokine level was regulated by JW administration. The levels inflammatory proteins were decreased by JW administration in the nasal mucosa of the OVA-sensitized mice. Eosinophils and mast cells infiltration increased by OVA-sensitization was also decreased in the JW-administered mice. In addition, JW inhibited caspase-1 activity in the same nasal mucosa tissue. In activated human mast cells, JW inhibited the receptor interacting protein-2, IκB kinase-β, nuclear factor-κB/Rel A, and caspase-1 activation. In conclusion, this study will be support the clear understanding of the concept of the spleen and the stomach in traditional Korean medicine as well as for a possibility of finding a cure for this AR in traditional medical treatments.
KW - Jeechool-Whan;allergic rhinitis;macrophage inflammatory protein-2;intercellular adhesion molecule-1;receptor interacting protein;caspase-1
DO -
UR -
ER -

오현아, 류재규, Wung-Seok Cha, Hyung-Min Kim and 정현자. (2012). Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model. CELLMED, 2(1), 9-9.

오현아, 류재규, Wung-Seok Cha, Hyung-Min Kim and 정현자. 2012, "Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model", CELLMED, vol.2, no.1 pp.9-9.

오현아, 류재규, Wung-Seok Cha, Hyung-Min Kim, 정현자 "Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model" CELLMED 2.1 pp.9-9 (2012) : 9.

오현아, 류재규, Wung-Seok Cha, Hyung-Min Kim, 정현자. Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model. 2012; 2(1), 9-9.

오현아, 류재규, Wung-Seok Cha, Hyung-Min Kim and 정현자. "Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model" CELLMED 2, no.1 (2012) : 9-9.

오현아; 류재규; Wung-Seok Cha; Hyung-Min Kim; 정현자. Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model. CELLMED, 2(1), 9-9.

오현아; 류재규; Wung-Seok Cha; Hyung-Min Kim; 정현자. Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model. CELLMED. 2012; 2(1) 9-9.

오현아, 류재규, Wung-Seok Cha, Hyung-Min Kim, 정현자. Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model. 2012; 2(1), 9-9.

오현아, 류재규, Wung-Seok Cha, Hyung-Min Kim and 정현자. "Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model" CELLMED 2, no.1 (2012) : 9-9.