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@article{ART002175854},
author={임홍균 and 김규엽 and Moon Phil-Dong},
title={Evidence of hydrolyzed traditional Korean red ginseng by malted barley on activation of receptor interacting proteins 2 and IkappaB kinase-beta in mouse peritoneal macrophages},
journal={CELLMED},
issn={3022-6805},
year={2012},
volume={2},
number={3},
pages={27-27}

TY - JOUR
AU - 임홍균
AU - 김규엽
AU - Moon Phil-Dong
TI - Evidence of hydrolyzed traditional Korean red ginseng by malted barley on activation of receptor interacting proteins 2 and IkappaB kinase-beta in mouse peritoneal macrophages
JO - CELLMED
PY - 2012
VL - 2
IS - 3
PB - Cellmed Orthocellular Medicine and Pharmaceutical Association
SP - 27
EP - 27
SN - 3022-6805
AB - Red ginseng, which has a variety of biological and pharmacological activities including antioxidant, anti-inflammatory, antimutagenic and anticarcinogenic effects, has been used for thousands of years as a general tonic in traditional oriental medicine. Here, we tested the immune regulatory activities of hydrolyzed red ginseng by malted barley (HRG) on the expressions of receptor interacting proteins (Rip) 2 and IB kinase-β (IKK-β) in mouse peritoneal macrophages. We show that HRG increased the activations of Rip 2 and IKK-β for the first time. When HRG was used in combination with recombinant interferon-γ (rIFN-γ), there was a marked cooperative induction of nitric oxide (NO) production. The increased expression of inducible NO synthase from rIFN-γ plus HRG-stimulated cells was almost completely inhibited by pre-treatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor-B (NF-κB). In addition, the treatment of peritoneal macrophages with rIFN-γ plus HRG caused significant increases in tumor necrosis factor (TNF)-α mRNA expression and production. Because NO and TNF-α play an important role in the immune function and host defense, HRG treatment can modulate several aspects of the host defense mechanisms as a result of the stimulations of the inducible nitric oxide synthase and NF-B. In conclusion, our findings demonstrate that HRG increases the productions of NO and TNF-α from rIFN-γ-primed macrophages and suggest that Rip2/IKK-β plays a critical role in mediating these immune regulatory effects of HRG.
KW - red ginseng;receptor interacting proteins 2;IB kinase-β;nuclear factor-B;tumor necrosis factor-α;nitric oxide
DO -
UR -
ER -

임홍균, 김규엽 and Moon Phil-Dong. (2012). Evidence of hydrolyzed traditional Korean red ginseng by malted barley on activation of receptor interacting proteins 2 and IkappaB kinase-beta in mouse peritoneal macrophages. CELLMED, 2(3), 27-27.

임홍균, 김규엽 and Moon Phil-Dong. 2012, "Evidence of hydrolyzed traditional Korean red ginseng by malted barley on activation of receptor interacting proteins 2 and IkappaB kinase-beta in mouse peritoneal macrophages", CELLMED, vol.2, no.3 pp.27-27.

임홍균, 김규엽, Moon Phil-Dong "Evidence of hydrolyzed traditional Korean red ginseng by malted barley on activation of receptor interacting proteins 2 and IkappaB kinase-beta in mouse peritoneal macrophages" CELLMED 2.3 pp.27-27 (2012) : 27.

임홍균, 김규엽, Moon Phil-Dong. Evidence of hydrolyzed traditional Korean red ginseng by malted barley on activation of receptor interacting proteins 2 and IkappaB kinase-beta in mouse peritoneal macrophages. 2012; 2(3), 27-27.

임홍균, 김규엽 and Moon Phil-Dong. "Evidence of hydrolyzed traditional Korean red ginseng by malted barley on activation of receptor interacting proteins 2 and IkappaB kinase-beta in mouse peritoneal macrophages" CELLMED 2, no.3 (2012) : 27-27.

임홍균; 김규엽; Moon Phil-Dong. Evidence of hydrolyzed traditional Korean red ginseng by malted barley on activation of receptor interacting proteins 2 and IkappaB kinase-beta in mouse peritoneal macrophages. CELLMED, 2(3), 27-27.

임홍균; 김규엽; Moon Phil-Dong. Evidence of hydrolyzed traditional Korean red ginseng by malted barley on activation of receptor interacting proteins 2 and IkappaB kinase-beta in mouse peritoneal macrophages. CELLMED. 2012; 2(3) 27-27.

임홍균, 김규엽, Moon Phil-Dong. Evidence of hydrolyzed traditional Korean red ginseng by malted barley on activation of receptor interacting proteins 2 and IkappaB kinase-beta in mouse peritoneal macrophages. 2012; 2(3), 27-27.

임홍균, 김규엽 and Moon Phil-Dong. "Evidence of hydrolyzed traditional Korean red ginseng by malted barley on activation of receptor interacting proteins 2 and IkappaB kinase-beta in mouse peritoneal macrophages" CELLMED 2, no.3 (2012) : 27-27.