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@article{ART002175877},
author={Zainul Amiruddin Zakaria and Nurul Husna Sodri and Halmy Hassan and Khairiyah Anuar and Fatimah Corazon Abdullah},
title={Effects of various receptor antagonists on the peripheral antinociceptive activity of aqueous extracts of Dicranopteris linearis, Melastoma malabathricum and Bauhinia purpurea leaves in mice},
journal={CELLMED},
issn={3022-6805},
year={2012},
volume={2},
number={4},
pages={38-38}

TY - JOUR
AU - Zainul Amiruddin Zakaria
AU - Nurul Husna Sodri
AU - Halmy Hassan
AU - Khairiyah Anuar
AU - Fatimah Corazon Abdullah
TI - Effects of various receptor antagonists on the peripheral antinociceptive activity of aqueous extracts of Dicranopteris linearis, Melastoma malabathricum and Bauhinia purpurea leaves in mice
JO - CELLMED
PY - 2012
VL - 2
IS - 4
PB - Cellmed Orthocellular Medicine and Pharmaceutical Association
SP - 38
EP - 38
SN - 3022-6805
AB - The present study aimed to determine the possible mechanisms of the peripheral antinociception of the aqueous extracts of Dicranopteris linearis (AEDL), Melastoma malabathricum (AEMM) and Bauhinia purpurea (AEBP) leaves in mice. Briefly, the antinociceptive profile of each extract (300, 500, and 1000 mg/kg; subcutaneous (s.c.)), was established using the abdominal constriction test. A single dose (500 mg/kg) of each extract (s.c.) was pre-challenged for 10 min with various pain receptors’ antagonists or pain mediators’ blockers and 30 min later subjected to the antinociceptive assay to determine the possible mechanism(s) involved. Based on the results obtained, all extracts exerted significant (p < 0.05) antinociceptive activity with dose-dependent activity observed only with the AEMM. Furthermore, the antinociception of AEDL was attenuated by naloxone, atropine, yohimbine and theophylline; AEMM was reversed by yohimbine, theophylline, thioperamide, pindolol, reserpine, and 4-chloro-DL-phenylalanine methyl ester hydrochloride; and of AEBP was inhibited by naloxone, haloperidol, yohimbine and reserpine. In conclusion, the antinociceptive activity of those extracts possibly involved the activation of several pain receptors (i.e. opioids, muscarinic, 2-adrenergic and adenosine receptors, adenosine, H3-histaminergic and 5HT1A, dopaminergic receptors).
KW - Dicranopteris linearis;Melastoma malabathricum;Bauhinia purpurea;aqueous extract;peripheral antinociception;abdominal constriction test;receptor antagonists
DO -
UR -
ER -

Zainul Amiruddin Zakaria, Nurul Husna Sodri, Halmy Hassan, Khairiyah Anuar and Fatimah Corazon Abdullah. (2012). Effects of various receptor antagonists on the peripheral antinociceptive activity of aqueous extracts of Dicranopteris linearis, Melastoma malabathricum and Bauhinia purpurea leaves in mice. CELLMED, 2(4), 38-38.

Zainul Amiruddin Zakaria, Nurul Husna Sodri, Halmy Hassan, Khairiyah Anuar and Fatimah Corazon Abdullah. 2012, "Effects of various receptor antagonists on the peripheral antinociceptive activity of aqueous extracts of Dicranopteris linearis, Melastoma malabathricum and Bauhinia purpurea leaves in mice", CELLMED, vol.2, no.4 pp.38-38.

Zainul Amiruddin Zakaria, Nurul Husna Sodri, Halmy Hassan, Khairiyah Anuar, Fatimah Corazon Abdullah "Effects of various receptor antagonists on the peripheral antinociceptive activity of aqueous extracts of Dicranopteris linearis, Melastoma malabathricum and Bauhinia purpurea leaves in mice" CELLMED 2.4 pp.38-38 (2012) : 38.

Zainul Amiruddin Zakaria, Nurul Husna Sodri, Halmy Hassan, Khairiyah Anuar, Fatimah Corazon Abdullah. Effects of various receptor antagonists on the peripheral antinociceptive activity of aqueous extracts of Dicranopteris linearis, Melastoma malabathricum and Bauhinia purpurea leaves in mice. 2012; 2(4), 38-38.

Zainul Amiruddin Zakaria, Nurul Husna Sodri, Halmy Hassan, Khairiyah Anuar and Fatimah Corazon Abdullah. "Effects of various receptor antagonists on the peripheral antinociceptive activity of aqueous extracts of Dicranopteris linearis, Melastoma malabathricum and Bauhinia purpurea leaves in mice" CELLMED 2, no.4 (2012) : 38-38.

Zainul Amiruddin Zakaria; Nurul Husna Sodri; Halmy Hassan; Khairiyah Anuar; Fatimah Corazon Abdullah. Effects of various receptor antagonists on the peripheral antinociceptive activity of aqueous extracts of Dicranopteris linearis, Melastoma malabathricum and Bauhinia purpurea leaves in mice. CELLMED, 2(4), 38-38.

Zainul Amiruddin Zakaria; Nurul Husna Sodri; Halmy Hassan; Khairiyah Anuar; Fatimah Corazon Abdullah. Effects of various receptor antagonists on the peripheral antinociceptive activity of aqueous extracts of Dicranopteris linearis, Melastoma malabathricum and Bauhinia purpurea leaves in mice. CELLMED. 2012; 2(4) 38-38.

Zainul Amiruddin Zakaria, Nurul Husna Sodri, Halmy Hassan, Khairiyah Anuar, Fatimah Corazon Abdullah. Effects of various receptor antagonists on the peripheral antinociceptive activity of aqueous extracts of Dicranopteris linearis, Melastoma malabathricum and Bauhinia purpurea leaves in mice. 2012; 2(4), 38-38.

Zainul Amiruddin Zakaria, Nurul Husna Sodri, Halmy Hassan, Khairiyah Anuar and Fatimah Corazon Abdullah. "Effects of various receptor antagonists on the peripheral antinociceptive activity of aqueous extracts of Dicranopteris linearis, Melastoma malabathricum and Bauhinia purpurea leaves in mice" CELLMED 2, no.4 (2012) : 38-38.