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@article{ART002175911},
author={Yan Yang and Xiaoxiang Zhang and Xin Liu and Chao Wu and Min-Zhu Chen},
title={Effects of compound traditional Astragalus and Salvia Miltiorrhiza extract on acute and chronic hepatic injury},
journal={CELLMED},
issn={3022-6805},
year={2013},
volume={3},
number={2},
pages={15-15}

TY - JOUR
AU - Yan Yang
AU - Xiaoxiang Zhang
AU - Xin Liu
AU - Chao Wu
AU - Min-Zhu Chen
TI - Effects of compound traditional Astragalus and Salvia Miltiorrhiza extract on acute and chronic hepatic injury
JO - CELLMED
PY - 2013
VL - 3
IS - 2
PB - Cellmed Orthocellular Medicine and Pharmaceutical Association
SP - 15
EP - 15
SN - 3022-6805
AB - Previous reports showed that Compound Astragalus and Salvia miltiorrhiza extract (CASE), which was mainly composed of astragalosides, astragalus polysaccharide and salvianolic acids, inhibited hepatic fibrosis by mediating transforming growth factor-β (TGF-β)/Smad signaling. Our aim was to examine the effects of CASE on D-galactosamine (D-GalN) treated liver injury in mice and carbon tetrachloride (CCl4)-induced liver fibrosis in rats. CASE was administered to mice with D-GalN-induced liver injury and to rats with CCl4-induced liver fibrosis, respectively. Liver injury was routinely evaluated by relative liver weight, serum levels of ALT, AST, hyaluronic acid (HA), hepatic malondialdehyde (MDA) content, superoxide dismutase (SOD) activity, hydroxyproline (HYP) and histopathologic changes. Treatment of mice with CASE (60, 120, and 240 mg/kg, ig) significantly lowered ALT, relative liver weight, and MDA levels when compared with D-GalN treated mice. CASE (120, 240 mg/kg) significantly lowered ALT, AST, HA, HYP, and MDA levels against CCl4 treated rats. Decreased SOD level was reversed with CASE treatment. Upon histopathological examination, CASE treatment had significantly inhibitory effect on the progression of hepatic fibrosis in rats. These results indicate that CASE might be effective in treatment and prevention of acute and chronic hepatic injury due to its antioxidant activity.
KW - compound Astragalus and Salvia miltiorrhiza extract;hepatic injury;antioxidant
DO -
UR -
ER -

Yan Yang, Xiaoxiang Zhang, Xin Liu, Chao Wu and Min-Zhu Chen. (2013). Effects of compound traditional Astragalus and Salvia Miltiorrhiza extract on acute and chronic hepatic injury. CELLMED, 3(2), 15-15.

Yan Yang, Xiaoxiang Zhang, Xin Liu, Chao Wu and Min-Zhu Chen. 2013, "Effects of compound traditional Astragalus and Salvia Miltiorrhiza extract on acute and chronic hepatic injury", CELLMED, vol.3, no.2 pp.15-15.

Yan Yang, Xiaoxiang Zhang, Xin Liu, Chao Wu, Min-Zhu Chen "Effects of compound traditional Astragalus and Salvia Miltiorrhiza extract on acute and chronic hepatic injury" CELLMED 3.2 pp.15-15 (2013) : 15.

Yan Yang, Xiaoxiang Zhang, Xin Liu, Chao Wu, Min-Zhu Chen. Effects of compound traditional Astragalus and Salvia Miltiorrhiza extract on acute and chronic hepatic injury. 2013; 3(2), 15-15.

Yan Yang, Xiaoxiang Zhang, Xin Liu, Chao Wu and Min-Zhu Chen. "Effects of compound traditional Astragalus and Salvia Miltiorrhiza extract on acute and chronic hepatic injury" CELLMED 3, no.2 (2013) : 15-15.

Yan Yang; Xiaoxiang Zhang; Xin Liu; Chao Wu; Min-Zhu Chen. Effects of compound traditional Astragalus and Salvia Miltiorrhiza extract on acute and chronic hepatic injury. CELLMED, 3(2), 15-15.

Yan Yang; Xiaoxiang Zhang; Xin Liu; Chao Wu; Min-Zhu Chen. Effects of compound traditional Astragalus and Salvia Miltiorrhiza extract on acute and chronic hepatic injury. CELLMED. 2013; 3(2) 15-15.

Yan Yang, Xiaoxiang Zhang, Xin Liu, Chao Wu, Min-Zhu Chen. Effects of compound traditional Astragalus and Salvia Miltiorrhiza extract on acute and chronic hepatic injury. 2013; 3(2), 15-15.

Yan Yang, Xiaoxiang Zhang, Xin Liu, Chao Wu and Min-Zhu Chen. "Effects of compound traditional Astragalus and Salvia Miltiorrhiza extract on acute and chronic hepatic injury" CELLMED 3, no.2 (2013) : 15-15.