Anticancer(AC)-Functional Kimchi Exhibits Antiobesity Effects in Differentiated 3T3-L1 Adipocytes

Eui-Seong Park; Seung-Min Lee; Yaung-lee Lim; Kun-Young Park

Anticancer(AC)-Functional Kimchi Exhibits Antiobesity Effects in Differentiated 3T3-L1 Adipocytes

CELLMED
Abbr : CellMed
2018, 8(3), pp.11-11
Publisher : Cellmed Orthocellular Medicine and Pharmaceutical Association
Research Area : Medicine and Pharmacy > General Medicine

Eui-Seong Park ¹, Seung-Min Lee ¹, Yaung-lee Lim ², Kun-Young Park ³

¹Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seodaemun-gu, Seoul, 03722, Republic of Korea
²Department of Food and Nutrition, Sungshin women’s University, Seungbuk-gu, Seoul, 01133, Republic of Korea
³Department of Food Science and Biotechnology, Cha University, Bundang-gu, Seongnam-si, Gyeonggi-do, 13488, Republic of Korea

Candidate

ABSTRACT

In vitro anti-obesity effects of anti-cancer (AC) functional kimchi in differentiated 3T3-L1 adipocytes were studied. We constructed three experimental groups: Control, standardized kimchi (SK), and AC functional kimchi (A-FK) that included active ingredients and Lactobacillus plantarum. Kimchi extracts did not show any cytotoxicity in pre-adipocytes in the concentration range of 1 – 5 mg/mL. A-FK significantly reduced fat droplet formation and absorbance in differentiated 3T3-L1 adipocytes, as shown by Oil red O staining, compared to Control and SK (P < 0.05). SK and A-FK reduced adipo-/lipogenesis related genes such as C/EBPα, SREBP-1, LPL, and LXRα compared to Control (P < 0.05). Especially, A-FK more greatly reduced SREBP-1 and LPL compared to SK (P < 0.05). A-FK up-regulated the β-oxidation related gene CPT-1c and down-regulated the pro-inflammatory cytokine IL-6 compared to Control (P < 0.05). Based on the results, A-FK exhibited anti-obesity effects by inhibiting fat droplet formation and adipo-/lipogenesis related genes by regulating the β-oxidation related gene CPT-1c and pro-inflammatory cytokine IL-6. In previous studies, A-FK kimchi already exhibited a strong anti-cancer effect. These results indicate that A-FK increased anti-obesity activity in this model system due to its functional ingredients and anti-cancer functionality.

KEYWORDS

Anti-obestiy, kimchi, Adipogenesis, Lipogenesis 3T3-L1 adipocyte

Citation status

* References for papers published after 2023 are currently being built.

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