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@article{ART002374943},
author={Abdulhakeem Olarewaju Sulyman and Jubril Olayinka Akolade and Raliat Abimbola Aladodo and Rasheed Bolaji Ibrahim and Asiat Na’Allah and Azeemat Titilola Abdulazeez},
title={Aristolochia ringens extract ameliorates oxidative stress and dyslipidaemia associated with streptozotocin-induced hyperglycaemia in rats},
journal={CELLMED},
issn={3022-6805},
year={2018},
volume={8},
number={3},
pages={12-12}

TY - JOUR
AU - Abdulhakeem Olarewaju Sulyman
AU - Jubril Olayinka Akolade
AU - Raliat Abimbola Aladodo
AU - Rasheed Bolaji Ibrahim
AU - Asiat Na’Allah
AU - Azeemat Titilola Abdulazeez
TI - Aristolochia ringens extract ameliorates oxidative stress and dyslipidaemia associated with streptozotocin-induced hyperglycaemia in rats
JO - CELLMED
PY - 2018
VL - 8
IS - 3
PB - Cellmed Orthocellular Medicine and Pharmaceutical Association
SP - 12
EP - 12
SN - 3022-6805
AB - The study was designed to assess antioxidant and antidyslipidaemic effects of terpenoid-rich extract from the root of Aristolochia ringens V. Hyperglycemia-induced oxidative stress and dyslipidemia were established in rats by single intraperitoneal administration of 65 mg/kg bw streptozotocin. Based on therapeutic dose determined in previous study, streptozotocin-induced rats were orally administered with 75 and 150 mg/Kg bw of A. ringens extract for 14 days. Total protein, serum lipid profiles and biomarkers of oxidative stress in liver and kidney of the experimental rats were determined. Atherogenic and cardiovascular disease risk indices were computed. Streptozotocin-induced hyperglycaemia significantly (p < 0.05) decreased activities of superoxide dismutase, catalase and glutathione transferase as well as the amount of reduced glutathione in both tissues indicating oxidative stress induced kidney and liver injury due to glucotoxicity. In comparison to non-treated hyperglycaemic rats, activities of the antioxidant enzymes and concentration of glutathione-H were significantly (p < 0.0001) increased, whereas malondialdehyde was reduced in the tissues of rats treated with both 75 and 150 mg/Kg bw of the extract. The extract also caused significant (p < 0.001) reduction in elevated levels of total cholesterol, triglycerides and low density lipoprotein-cholesterol levels, whereas concentration of the attenuated high density lipoprotein-cholesterol was increased in serum of the treated rats. Reduced atherogenic and cardiac risk indices were projected for the A. ringens extract-treated groups. Results from this study showed that extract from A. ringens root was rich in terpenoids and may reduce risks of complications associated with hyperglycemia-induced oxidative stress and dyslipidemia.
KW - Aristolochia ringens;diabetes;Dyslipidemia;Hyperglycaemia;Oxidative stress
DO -
UR -
ER -

Abdulhakeem Olarewaju Sulyman, Jubril Olayinka Akolade, Raliat Abimbola Aladodo, Rasheed Bolaji Ibrahim, Asiat Na’Allah and Azeemat Titilola Abdulazeez. (2018). Aristolochia ringens extract ameliorates oxidative stress and dyslipidaemia associated with streptozotocin-induced hyperglycaemia in rats. CELLMED, 8(3), 12-12.

Abdulhakeem Olarewaju Sulyman, Jubril Olayinka Akolade, Raliat Abimbola Aladodo, Rasheed Bolaji Ibrahim, Asiat Na’Allah and Azeemat Titilola Abdulazeez. 2018, "Aristolochia ringens extract ameliorates oxidative stress and dyslipidaemia associated with streptozotocin-induced hyperglycaemia in rats", CELLMED, vol.8, no.3 pp.12-12.

Abdulhakeem Olarewaju Sulyman, Jubril Olayinka Akolade, Raliat Abimbola Aladodo, Rasheed Bolaji Ibrahim, Asiat Na’Allah, Azeemat Titilola Abdulazeez "Aristolochia ringens extract ameliorates oxidative stress and dyslipidaemia associated with streptozotocin-induced hyperglycaemia in rats" CELLMED 8.3 pp.12-12 (2018) : 12.

Abdulhakeem Olarewaju Sulyman, Jubril Olayinka Akolade, Raliat Abimbola Aladodo, Rasheed Bolaji Ibrahim, Asiat Na’Allah, Azeemat Titilola Abdulazeez. Aristolochia ringens extract ameliorates oxidative stress and dyslipidaemia associated with streptozotocin-induced hyperglycaemia in rats. 2018; 8(3), 12-12.

Abdulhakeem Olarewaju Sulyman, Jubril Olayinka Akolade, Raliat Abimbola Aladodo, Rasheed Bolaji Ibrahim, Asiat Na’Allah and Azeemat Titilola Abdulazeez. "Aristolochia ringens extract ameliorates oxidative stress and dyslipidaemia associated with streptozotocin-induced hyperglycaemia in rats" CELLMED 8, no.3 (2018) : 12-12.

Abdulhakeem Olarewaju Sulyman; Jubril Olayinka Akolade; Raliat Abimbola Aladodo; Rasheed Bolaji Ibrahim; Asiat Na’Allah; Azeemat Titilola Abdulazeez. Aristolochia ringens extract ameliorates oxidative stress and dyslipidaemia associated with streptozotocin-induced hyperglycaemia in rats. CELLMED, 8(3), 12-12.

Abdulhakeem Olarewaju Sulyman; Jubril Olayinka Akolade; Raliat Abimbola Aladodo; Rasheed Bolaji Ibrahim; Asiat Na’Allah; Azeemat Titilola Abdulazeez. Aristolochia ringens extract ameliorates oxidative stress and dyslipidaemia associated with streptozotocin-induced hyperglycaemia in rats. CELLMED. 2018; 8(3) 12-12.

Abdulhakeem Olarewaju Sulyman, Jubril Olayinka Akolade, Raliat Abimbola Aladodo, Rasheed Bolaji Ibrahim, Asiat Na’Allah, Azeemat Titilola Abdulazeez. Aristolochia ringens extract ameliorates oxidative stress and dyslipidaemia associated with streptozotocin-induced hyperglycaemia in rats. 2018; 8(3), 12-12.

Abdulhakeem Olarewaju Sulyman, Jubril Olayinka Akolade, Raliat Abimbola Aladodo, Rasheed Bolaji Ibrahim, Asiat Na’Allah and Azeemat Titilola Abdulazeez. "Aristolochia ringens extract ameliorates oxidative stress and dyslipidaemia associated with streptozotocin-induced hyperglycaemia in rats" CELLMED 8, no.3 (2018) : 12-12.