@article{ART003266464},
author={Jong Ae Choi and Seong-Hoon Yun and Hye-Yeon Kang and Sunyoung Park and Sung-Bae Lee and Gun-Woo Lee and Youngsun Kwon and Hee-Yeong Jeong and Sang-Eun Shin and Na Rae Park and Bong-Keun Jang and SHIN KWANG SOON},
title={Neuroprotective Effects of Nebbiolo Red Wine Against Ethanol-induced Cognitive Dysfunction and Neurotoxicity},
journal={CELLMED},
issn={3022-6805},
year={2025},
volume={15},
number={14},
pages={11-16},
doi={10.5667/CellMed.2025.015}
TY - JOUR
AU - Jong Ae Choi
AU - Seong-Hoon Yun
AU - Hye-Yeon Kang
AU - Sunyoung Park
AU - Sung-Bae Lee
AU - Gun-Woo Lee
AU - Youngsun Kwon
AU - Hee-Yeong Jeong
AU - Sang-Eun Shin
AU - Na Rae Park
AU - Bong-Keun Jang
AU - SHIN KWANG SOON
TI - Neuroprotective Effects of Nebbiolo Red Wine Against Ethanol-induced Cognitive Dysfunction and Neurotoxicity
JO - CELLMED
PY - 2025
VL - 15
IS - 14
PB - Cellmed Orthocellular Medicine and Pharmaceutical Association
SP - 11
EP - 16
SN - 3022-6805
AB - Objective: Chronic alcohol consumption causes neurotoxicity, yet moderate red wine consumption is linked to health benefits, often attributed to its polyphenols. This study investigated whether Nebbiolo red wine (NRW), a variety with high polyphenol content, possesses sufficient neuroprotective capacity to counteract the concurrent neurotoxic effects of its own ethanol (EtOH) content.
Materials and Methods: Neuroprotective effects were evaluated in vitro (SH-SY5Y cells, WST-8 assay) and in vivo (mice, Y-maze test) following exposure to 14% EtOH or 14% NRW. Antioxidant capacity was determined by DPPH and ORAC assays.
Results: NRW demonstrated robust dose-dependent antioxidant activity. In vitro, NRWP significantly protected SH-SY5Y cells from EtOH-induced cytotoxicity. In vivo, 14% EtOH administration severely impaired spatial memory (27.1% alternation vs. 67.5% Sham), an effect completely prevented by 14% NRW (65% alternation).
Conclusion: NRW mediates significant neuroprotection, effectively neutralizing ethanol-induced cytotoxicity in vitro and cognitive impairment in vivo. This suggests polyphenolic content is a critical determinant of alcohol's net neurological impact.
KW - Nebbiolo red wine;Ethanol;Neuroprotection;Oxidative Stress;Cognitive Impairment;Y-maze
DO - 10.5667/CellMed.2025.015
ER -
Jong Ae Choi, Seong-Hoon Yun, Hye-Yeon Kang, Sunyoung Park, Sung-Bae Lee, Gun-Woo Lee, Youngsun Kwon, Hee-Yeong Jeong, Sang-Eun Shin, Na Rae Park, Bong-Keun Jang and SHIN KWANG SOON. (2025). Neuroprotective Effects of Nebbiolo Red Wine Against Ethanol-induced Cognitive Dysfunction and Neurotoxicity. CELLMED, 15(14), 11-16.
Jong Ae Choi, Seong-Hoon Yun, Hye-Yeon Kang, Sunyoung Park, Sung-Bae Lee, Gun-Woo Lee, Youngsun Kwon, Hee-Yeong Jeong, Sang-Eun Shin, Na Rae Park, Bong-Keun Jang and SHIN KWANG SOON. 2025, "Neuroprotective Effects of Nebbiolo Red Wine Against Ethanol-induced Cognitive Dysfunction and Neurotoxicity", CELLMED, vol.15, no.14 pp.11-16. Available from: doi:10.5667/CellMed.2025.015
Jong Ae Choi, Seong-Hoon Yun, Hye-Yeon Kang, Sunyoung Park, Sung-Bae Lee, Gun-Woo Lee, Youngsun Kwon, Hee-Yeong Jeong, Sang-Eun Shin, Na Rae Park, Bong-Keun Jang, SHIN KWANG SOON "Neuroprotective Effects of Nebbiolo Red Wine Against Ethanol-induced Cognitive Dysfunction and Neurotoxicity" CELLMED 15.14 pp.11-16 (2025) : 11.
Jong Ae Choi, Seong-Hoon Yun, Hye-Yeon Kang, Sunyoung Park, Sung-Bae Lee, Gun-Woo Lee, Youngsun Kwon, Hee-Yeong Jeong, Sang-Eun Shin, Na Rae Park, Bong-Keun Jang, SHIN KWANG SOON. Neuroprotective Effects of Nebbiolo Red Wine Against Ethanol-induced Cognitive Dysfunction and Neurotoxicity. 2025; 15(14), 11-16. Available from: doi:10.5667/CellMed.2025.015
Jong Ae Choi, Seong-Hoon Yun, Hye-Yeon Kang, Sunyoung Park, Sung-Bae Lee, Gun-Woo Lee, Youngsun Kwon, Hee-Yeong Jeong, Sang-Eun Shin, Na Rae Park, Bong-Keun Jang and SHIN KWANG SOON. "Neuroprotective Effects of Nebbiolo Red Wine Against Ethanol-induced Cognitive Dysfunction and Neurotoxicity" CELLMED 15, no.14 (2025) : 11-16.doi: 10.5667/CellMed.2025.015
Jong Ae Choi; Seong-Hoon Yun; Hye-Yeon Kang; Sunyoung Park; Sung-Bae Lee; Gun-Woo Lee; Youngsun Kwon; Hee-Yeong Jeong; Sang-Eun Shin; Na Rae Park; Bong-Keun Jang; SHIN KWANG SOON. Neuroprotective Effects of Nebbiolo Red Wine Against Ethanol-induced Cognitive Dysfunction and Neurotoxicity. CELLMED, 15(14), 11-16. doi: 10.5667/CellMed.2025.015
Jong Ae Choi; Seong-Hoon Yun; Hye-Yeon Kang; Sunyoung Park; Sung-Bae Lee; Gun-Woo Lee; Youngsun Kwon; Hee-Yeong Jeong; Sang-Eun Shin; Na Rae Park; Bong-Keun Jang; SHIN KWANG SOON. Neuroprotective Effects of Nebbiolo Red Wine Against Ethanol-induced Cognitive Dysfunction and Neurotoxicity. CELLMED. 2025; 15(14) 11-16. doi: 10.5667/CellMed.2025.015
Jong Ae Choi, Seong-Hoon Yun, Hye-Yeon Kang, Sunyoung Park, Sung-Bae Lee, Gun-Woo Lee, Youngsun Kwon, Hee-Yeong Jeong, Sang-Eun Shin, Na Rae Park, Bong-Keun Jang, SHIN KWANG SOON. Neuroprotective Effects of Nebbiolo Red Wine Against Ethanol-induced Cognitive Dysfunction and Neurotoxicity. 2025; 15(14), 11-16. Available from: doi:10.5667/CellMed.2025.015
Jong Ae Choi, Seong-Hoon Yun, Hye-Yeon Kang, Sunyoung Park, Sung-Bae Lee, Gun-Woo Lee, Youngsun Kwon, Hee-Yeong Jeong, Sang-Eun Shin, Na Rae Park, Bong-Keun Jang and SHIN KWANG SOON. "Neuroprotective Effects of Nebbiolo Red Wine Against Ethanol-induced Cognitive Dysfunction and Neurotoxicity" CELLMED 15, no.14 (2025) : 11-16.doi: 10.5667/CellMed.2025.015
