Intercalation behavior study of ibuprofen/clay organic-inorganic nanocomposites as drug release system (약물 방출 시스템으로서 이부프로펜/클레이 유-무기 나노복합체의 층간삽입 거동 연구)

최봉석; 김동현; Taewan Kim (김태완); 진형호; PARK，HONG-CHAE (박홍채); Seog-Young Yoon (윤석영)

Intercalation behavior study of ibuprofen/clay organic-inorganic nanocomposites as drug release system

Journal of the Korean Crystal Growth and Crystal Technology
Abbr : J. Korean Cryst. Growth Cryst. Technol.
2011, 21(6), pp.240-245
Publisher : The Korea Association Of Crystal Growth, Inc.
Research Area : Engineering > Materials Science and Engineering

최봉석 ¹, 김동현 ¹, Taewan Kim ¹, 진형호 ¹, PARK，HONG-CHAE ¹, Seog-Young Yoon ¹

¹부산대학교

Accredited

ABSTRACT

This research focused on the intercalation behavior of recrystallized ibuprofen into clay as a sustained release drug carrier. The intercalation behaviors of ibuprofen were determined by X-ray diffraction (XRD) and thermogravimetric analysis (TGA). The basal spacing (d001) of clay increased from 1.2 nm to 1.5 nm by ibuprofen molecules. The segmental motion effect of ibuprofen into the clay interlayer spacing also increased the thermal stability of the ibuprofen/clay nanocomposites. The in vitro drug release results of nanocomposites showed that ibuprofen was released from clay steadily.

KEYWORDS

Clay, Intercalation, Ibuprofen, Nanocomposites

Citation status

* References for papers published after 2023 are currently being built.

[journal] M.M. Wolfe / 1999 / Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs / New Engl. J. Med 1888 : 340~

[book] H. Schott / 1990 / Remington's Pharmaceutical Science, (18th edn) / Mack, Easton, Pennsylvania

[journal] A.I. Arida / 1999 / Development of sustained-release ibuprofen microspheres using solvent evaporation technique / Arch. Pharm 405 : 332~

[journal] M. Adachi / 2007 / Nonsteroidal anti-inflammatory drugs and oxidative stress in cancer cells / Histol Histopathol 4 : 437~

[journal] M.C. Branco / 2009 / Self-assembling materials for therapeutic delivery / Acta Biomaterialia 5 : 817~

[journal] S. Bourbogot / 2004 / Kinetic analysis of the thermal degradation of polystyrene-montmorillonite nanocomposite / Polym. Degrad. Stab 84 : 483~

[journal] X. Wang / 2008 / Biopolymer/montmorillonite nanocomposite: preparation, drug-controlled release property and cytotoxicity / Nanotechnology 19 : 065707~

[journal] D. Depan / 2009 / Design and evaluation of controlled drug delivery system of buspirone using / Acta Biomater 5 : 93~

[journal] L. Zheng-Rong / 2007 / Polymer platforms for drug delivery and biomedical imaging / J. Control. Release 122 : 269~

[journal] S.S. Ray / 2005 / Biodegradable polymers and their layered silicate nanocomposites: In greening the 21st century materials world / Prog. Mater. Sci 50 : 962~

[journal] V. Ambrogi / 2008 / Eudragit and hydrotalcite- like anionic clay composite system for diclofenac colonic delivery / Micropor. Mesopor. Mater 115 : 405~

[journal] L. Bingxin / 2004 / Entericcoated layered double hydroxides as a controlled release drug delivery system / Int. J. Pharm 287 : 89~

[journal] C.D. Nunes / 2007 / Loading and delivery of sertraline using inorganic micro and mesoporous materials / Eur. J. Pharm. Biopharm 66 : 357~

[journal] J.K. Park / 2008 / Controlled release of donepezil intercalated in smectite clays / INTERNATIONAL JOURNAL OF PHARMACEUTICS / ELSEVIER SCIENCE BV 359(1-2) : 198~204

[journal] J.M. Oh / 2009 / Layered nanomaterials for green materials / JOURNAL OF MATERIALS CHEMISTRY / ROYAL SOC CHEMISTRY 19(17) : 2553~2563

[journal] H. Zhang / 2006 / Nanostructural drug-inorganic clay composites: Structure, thermal property and in vitro release of captopril-intercalated Mg-Al-layered double hydroxides / J. Solid State Chem 179 : 1792~

[journal] G.V. Joshi / 2009 / Montmorillonite as a drug delivery system: Intercalation and in vitro release of timolol maleate / Int. J. Pharm 374 : 53~

[journal] X. Wang / 2007 / Chitosan/organic rectorite nanocomposite films: Structure, characteristic and drug delivery behaviour / Carbohyd. Polym 69 : 41~

[journal] S.R. Levis / 2003 / Use of coated microtubular halloysite for the sustained release of diltiazem hydrochloride and propranolol hydrochloride / Int. J. Pharm 253 : 145~

[journal] A. Valeria / 2001 / Intercalation compounds of hydrotalcite-like anionic clays with antiinflammatory agents-I Intercalation and in vitro release of ibuprofen / Int. J. Pharm 220 : 23~

[journal] T. Takahashi / 1991 / Host-guest interaction between swelling clay mineralsand poorly watersoluble drugs. 1: Complex formation between a swelling clay mineral and griseofulvin / J. Incl. Phenom. Macro 10 : 283~

[journal] S. Karaboni / 1996 / The swelling of clays: Molecular simulations of the hydration of montmorillonite / Science 271 : 1102~

[journal] E.S. Boek / 1995 / Monte carlo molecular modeling studies of hydrated Li-, Na-, and Ksmectites: Understanding the role of potassium as a clay swelling inhibitor / J. Am. Chem. Soc 117 : 12608~

[journal] N.T. Skipper / 1991 / Computer simulation of interlayer water in 2:1 clays / J. Chem. Phys 94 : 7434~

[book] C.S. Hutchison / 1973 / Laboratory Handbook of Petrographic Techniques / McGraw-Hill Book Co, New York

This paper was written with support from the National Research Foundation of Korea.

KJCKorea
Journal Central

Journal of the Korean Crystal Growth and Crystal Technology 2023 KCI Impact Factor : 0.19