Fabrication and characterization of porous hydroxyapatite scaffolds with PMMA addition using tertiary-butyl alcohol based freeze casting method (삼차부틸알코올 기반 동결주조 공정을 이용한 PMMA 첨가 다공질 수산화아파타이트 지지체의 제조 및 특성 평가)

Tae-Rim Kim (김태림); Seog-Young Yoon (윤석영); Jin-Young Heo (허진영); Chiseung Lee (이치승)

doi:10.6111/JKCGCT.2017.27.5.235

Fabrication and characterization of porous hydroxyapatite scaffolds with PMMA addition using tertiary-butyl alcohol based freeze casting method

Journal of the Korean Crystal Growth and Crystal Technology
Abbr : J. Korean Cryst. Growth Cryst. Technol.
2017, 27(5), pp.235-242
DOI : 10.6111/JKCGCT.2017.27.5.235
Publisher : The Korea Association Of Crystal Growth, Inc.
Research Area : Engineering > Materials Science and Engineering
Received : August 11, 2017
Accepted : September 22, 2017
Published : October 31, 2017

Tae-Rim Kim ¹, Seog-Young Yoon ¹, Jin-Young Heo ², Chiseung Lee ¹

¹부산대학교
²(주)에스원바이오

Accredited

ABSTRACT

In order to prepare porous scaffolds capable of pore control, PMMA powder serving as a pore-forming agent was added to HA powder to synthesize a slurry containing TBA as a solvent. And then, porous HA scaffolds where pillarshaped pore channels interconnected with each other were fabricated by freeze-casting and sintering. The crystal structure of the HA scaffolds according to the addition amount of PMMA powder was measured by XRD and the surface and inner cross section of the scaffolds were analyzed through SEM. It was found that removal of PMMA during sintering affects the internal structure of the scaffolds and the crystallinity of the HA powder. Furthermore, through evaluating the physical and mechanical properties of the scaffolds, it was confirmed that the porosity, pore size and compressive strength can be controlled by controlling the addition amount of the pore-forming agent. It was also found that the HA scaffolds produced in this study were similar in structure and properties to the natural cancellous bone. This suggests that porous HA scaffolds with PMMA can be used as an alternative to autogenous bone for tissue engineering as an artificial bone scaffold.

KEYWORDS

Hydroxyapatite, PMMA, Scaffold, Freeze casting, Tertiary-butyl alcohol, Compressive strength, Porosity, Pore size

Citation status

* References for papers published after 2023 are currently being built.

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Journal of the Korean Crystal Growth and Crystal Technology 2023 KCI Impact Factor : 0.19

Fabrication and characterization of porous hydroxyapatite scaffolds with PMMA addition using tertiary-butyl alcohol based freeze casting method

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* References for papers published after 2023 are currently being built.

Journal of the Korean Crystal Growth and Crystal Technology 2023 KCI Impact Factor : 0.19

Fabrication and characterization of porous hydroxyapatite scaffolds with PMMA addition using tertiary-butyl alcohol based freeze casting method

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