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Anti-Obesity Effects of Fermented Samjung-hwan in High Fat Diet Rats

  • Journal of Korean Medicine for Obesity Research
  • Abbr : J Korean Med Obes Res
  • 2013, 13(1), pp.17-23
  • Publisher : The Society of Korean Medicine for Obesity Research
  • Research Area : Medicine and Pharmacy > Korean Medicine

송미영 1 Shambhunath Bose 2 Hojun Kim 1

1동국대학교 한의과대학 한방재활의학과교실
2동국대학교

ABSTRACT

Objectives: This study was performed to evaluate the effects of fermented Samjung-hwan (SJH)extracts on weight, serum lipids and blood glucose. Methods: SJH was fermented using three different probiotic bacterial strains (Lactobacillusplantarum [LP], Leuconostoc mesenteroides [LM], Bifidobacterium longum [BL]) separately. Thirty-six rats were divided into normal, control (high fat diet), SJH-UF (high fatdiet+unfermented SJH 200 mg/kg), SJH-LP (high fat diet+LP fermented SJH 200 mg/kg),SJH-LM (high fat diet+LM fermented SJH 200 mg/kg) and SJH-BL (high fat diet+BLfermented SJH 200 mg/kg). For 8 weeks later, we examined body weight, total cholesterol,high-density lipoprotein (HDL)-cholesterol and blood glucose. Results: The control group showed significantly increased weight gain compared with normalgroup and SJH-LP and BL groups had less weight gain than control group, significantly. In the lipidserum tests, control group showed significantly increased total cholesterol levels compared withnormal group and only SJH-LP represented decreased total cholesterol levels compared withcontrol group. However there was no significant change in the HDL-cholesteol levels. In the bloodglucose tests, that of control group significantly incereased more than that of normal group, SJH-BL showed significantly decreased blood glucose levels compared with control group. Conclusions: SJH-LP,SJH-BL showed weight control effect, SJH-LP decreased TC and SJH-BL reduced blood glucose.

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