Favorable Control Effects of Palmijihwang-Whan on the Propylthiouracil Induced Hypothyroidism Related Rat Male Reproductive Organ Damages Seung-Mo (팔미지황환의 Propylthiouracil로 유발된 Rat 갑상샘기능저하성 웅성 생식기 손상 제어 효과)

Seung-Mo Kim (김승모)

Favorable Control Effects of Palmijihwang-Whan on the Propylthiouracil Induced Hypothyroidism Related Rat Male Reproductive Organ Damages Seung-Mo

Journal of Korean Medicine for Obesity Research
Abbr : J Korean Med Obes Res
2015, 15(2), pp.55-67
Publisher : The Society of Korean Medicine for Obesity Research
Research Area : Medicine and Pharmacy > Korean Medicine
Published : December 30, 2015

Seung-Mo Kim ¹

¹대구한의대학교

Candidate

ABSTRACT

Objectives: This study was to evaluate the effect of Palmijihwang-whan (PMJHW) aqueousextract in the regulation of hypothyroidism related reproductive organ damages in propylthiouracil(PTU)-induced rat model. Methods: PMJHW aqueous extract (yield=17.90%) were administered, once a day for 42 daysfrom 2 weeks before start of PTU treatment as oral doses of 500, 250, and 125 mg/kg (bodyweight), and hypothyroidism was induced by daily subcutaneous treatment of PTU 10 mg/kg for28 days. Results: PTU-induced hypothyroidism and related male reproductive organ damages–atrophicchanges of testis, epididymis and prostate, were favorably and dose-dependently inhibited bytreatment of PMJHW 500, 250, and 125 mg/kg. They also effectively regulated the PTU-inducedabnormal antioxidant defense system changes in the testis. Although levothyroxine also favorablyinhibited PTU-induced hypothyroidism, it deteriorated the hypothyroidism related male reproductiveorgan damages through testicular oxidative damages. The results suggest that oral administrationof 125, 250, and 500 mg/kg of PMJHW has favorable effects on the hypothyroidism andrelated reproductive organ damages through augmentation of antioxidant defense system in thetestis. Conclusions: This study suggest that PMJHW may be help to ameliorate the hypothyroidism andrelated organ damages in clinics. Key Words: Palmijihwang-whan, Hypothyroidism

KEYWORDS

Palmijihwang-whan, Hypothyroidism, Male reproductive organ damages, Propylthiouracil, Histopathology, Antioxidants

Citation status

* References for papers published after 2023 are currently being built.

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