@article{ART002063479},
author={Seung-Mo Kim},
title={Favorable Control Effects of Palmijihwang-Whan on the Propylthiouracil Induced Hypothyroidism Related Rat Male Reproductive Organ Damages Seung-Mo},
journal={Journal of Korean Medicine for Obesity Research},
issn={1976-9334},
year={2015},
volume={15},
number={2},
pages={55-67}
TY - JOUR
AU - Seung-Mo Kim
TI - Favorable Control Effects of Palmijihwang-Whan on the Propylthiouracil Induced Hypothyroidism Related Rat Male Reproductive Organ Damages Seung-Mo
JO - Journal of Korean Medicine for Obesity Research
PY - 2015
VL - 15
IS - 2
PB - The Society of Korean Medicine for Obesity Research
SP - 55
EP - 67
SN - 1976-9334
AB - Objectives: This study was to evaluate the effect of Palmijihwang-whan (PMJHW) aqueousextract in the regulation of hypothyroidism related reproductive organ damages in propylthiouracil(PTU)-induced rat model.
Methods: PMJHW aqueous extract (yield=17.90%) were administered, once a day for 42 daysfrom 2 weeks before start of PTU treatment as oral doses of 500, 250, and 125 mg/kg (bodyweight), and hypothyroidism was induced by daily subcutaneous treatment of PTU 10 mg/kg for28 days.
Results: PTU-induced hypothyroidism and related male reproductive organ damages–atrophicchanges of testis, epididymis and prostate, were favorably and dose-dependently inhibited bytreatment of PMJHW 500, 250, and 125 mg/kg. They also effectively regulated the PTU-inducedabnormal antioxidant defense system changes in the testis. Although levothyroxine also favorablyinhibited PTU-induced hypothyroidism, it deteriorated the hypothyroidism related male reproductiveorgan damages through testicular oxidative damages. The results suggest that oral administrationof 125, 250, and 500 mg/kg of PMJHW has favorable effects on the hypothyroidism andrelated reproductive organ damages through augmentation of antioxidant defense system in thetestis.
Conclusions: This study suggest that PMJHW may be help to ameliorate the hypothyroidism andrelated organ damages in clinics.
Key Words: Palmijihwang-whan, Hypothyroidism
KW - Palmijihwang-whan;Hypothyroidism;Male reproductive organ damages;Propylthiouracil;Histopathology;Antioxidants
DO -
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Seung-Mo Kim. (2015). Favorable Control Effects of Palmijihwang-Whan on the Propylthiouracil Induced Hypothyroidism Related Rat Male Reproductive Organ Damages Seung-Mo. Journal of Korean Medicine for Obesity Research, 15(2), 55-67.
Seung-Mo Kim. 2015, "Favorable Control Effects of Palmijihwang-Whan on the Propylthiouracil Induced Hypothyroidism Related Rat Male Reproductive Organ Damages Seung-Mo", Journal of Korean Medicine for Obesity Research, vol.15, no.2 pp.55-67.
Seung-Mo Kim "Favorable Control Effects of Palmijihwang-Whan on the Propylthiouracil Induced Hypothyroidism Related Rat Male Reproductive Organ Damages Seung-Mo" Journal of Korean Medicine for Obesity Research 15.2 pp.55-67 (2015) : 55.
Seung-Mo Kim. Favorable Control Effects of Palmijihwang-Whan on the Propylthiouracil Induced Hypothyroidism Related Rat Male Reproductive Organ Damages Seung-Mo. 2015; 15(2), 55-67.
Seung-Mo Kim. "Favorable Control Effects of Palmijihwang-Whan on the Propylthiouracil Induced Hypothyroidism Related Rat Male Reproductive Organ Damages Seung-Mo" Journal of Korean Medicine for Obesity Research 15, no.2 (2015) : 55-67.
Seung-Mo Kim. Favorable Control Effects of Palmijihwang-Whan on the Propylthiouracil Induced Hypothyroidism Related Rat Male Reproductive Organ Damages Seung-Mo. Journal of Korean Medicine for Obesity Research, 15(2), 55-67.
Seung-Mo Kim. Favorable Control Effects of Palmijihwang-Whan on the Propylthiouracil Induced Hypothyroidism Related Rat Male Reproductive Organ Damages Seung-Mo. Journal of Korean Medicine for Obesity Research. 2015; 15(2) 55-67.
Seung-Mo Kim. Favorable Control Effects of Palmijihwang-Whan on the Propylthiouracil Induced Hypothyroidism Related Rat Male Reproductive Organ Damages Seung-Mo. 2015; 15(2), 55-67.
Seung-Mo Kim. "Favorable Control Effects of Palmijihwang-Whan on the Propylthiouracil Induced Hypothyroidism Related Rat Male Reproductive Organ Damages Seung-Mo" Journal of Korean Medicine for Obesity Research 15, no.2 (2015) : 55-67.