2015, Vol.15, No.2

Journal of Korean Medicine for Obesity Research 2023 KCI Impact Factor : 0.43

pISSN : 1976-9334 / eISSN : 2288-1522
https://journal.kci.go.kr/jkomor

Objectives: This study was to evaluate the effect of Palmijihwang-whan (PMJHW) aqueousextract in the regulation of hypothyroidism related reproductive organ damages in propylthiouracil(PTU)-induced rat model. Methods: PMJHW aqueous extract (yield=17.90%) were administered, once a day for 42 daysfrom 2 weeks before start of PTU treatment as oral doses of 500, 250, and 125 mg/kg (bodyweight), and hypothyroidism was induced by daily subcutaneous treatment of PTU 10 mg/kg for28 days. Results: PTU-induced hypothyroidism and related male reproductive organ damages–atrophicchanges of testis, epididymis and prostate, were favorably and dose-dependently inhibited bytreatment of PMJHW 500, 250, and 125 mg/kg. They also effectively regulated the PTU-inducedabnormal antioxidant defense system changes in the testis. Although levothyroxine also favorablyinhibited PTU-induced hypothyroidism, it deteriorated the hypothyroidism related male reproductiveorgan damages through testicular oxidative damages. The results suggest that oral administrationof 125, 250, and 500 mg/kg of PMJHW has favorable effects on the hypothyroidism andrelated reproductive organ damages through augmentation of antioxidant defense system in thetestis. Conclusions: This study suggest that PMJHW may be help to ameliorate the hypothyroidism andrelated organ damages in clinics. Key Words: Palmijihwang-whan, Hypothyroidism

Objectives: The purpose of this study was to investigate the effects of Shengmai-san andPyungwi-san, a herbal product used in traditional Chinese medicine, on gastrointestinal (GI)motility in mice. Methods: The in vivo effects of Shengmai-san and Pyungwi-san on GI motility were investigatedby measuring the intestinal transit rates (ITRs) using Evans blue in normal mice and in mice withexperimentally induced GI motility dysfunction (GMD). GMD was induced by injecting acetic acidor streptozotocin intraperitoneally. Results: In normal Institute of Cancer Research mice, ITRs were significantly and dosedependentlyincreased by Shengmaisan (0.01∼1 g/kg) and Pyungwi-san (0.01∼1 g/kg). TheITRs of acetic acid induced peritoneal irritation model and streptozotocin-induced diabetic modelmice were significantly reduced compared to normal mice, and these reductions were significantlyand dose-dependently inhibited by Shengmai-san (0.01∼1 g/kg) and Pyungwi-san (0.01∼1g/kg). Conclusions: These results suggest that both Shengmai-san and Pyungwi-san are a goodcandidate for the development of a prokinetic agent that may prevent or alleviate GMD

Objectives: This study was designed to investigate the effect of Gami-cheongpyesagan-tangextract (GCST) on high fat diet-induced obesity in rats. Methods: The mice were divided into six groups; normal diet control, high fat diet control (HFD),HFD＋GCST administrated group (100, 200, and 400 mg/kg) and olistat-admistrated group. Obesity was induced by high fat diet (45%) for 7 weeks in mice, and GCST was administratedorally every day for 7 weeks. The body weight, food intake, and serological markers such as totalcholesterol, triglyceride, lipid contents, leptin, adiponectin and glutamic oxaloacetictransaminase/glutamic pyruvic transaminase were measured in mice. The mRNA expression ofobese-associating genes such as sterol regulatory element-binding protein (SREBP)-1c, fattyacid synthase (FAS), stearoyl-CaP desaturase (SCD-1), peroxisome proliferator-activatedreceptor (PPAR)-, COA oxidase (ACO), and carnitine palmitoyltransferase (CPT-1) wasanalyzed by reverse transcription polymerase chain reaction. Results: The administration of GCST at 400 mg/kg, significantly reduced the increase of bodyweight and food intake as well as food efficiency compared to HFD group. GCST decreased theserum levels of triglyceride, total cholesterol, low-density lipoprotein-cholesterol, leptin in HFDcontrol group and inhibited lipid accumulation in liver and adipose tissues, but did not increasehigh-density lipoprotein-cholesterol. In the liver tissues of GCST administrated HFD group, themRNA levels of SREBP-1c, FAS and SCD-1 were decreased and the mRNA levels of PPAR-,ACO, and CPT-1 were increased. Conclusions: These results indicate that GCST could improve high fat diet induced obesitythrough inhibiting the hyperlipidemia in fatty Liver. It suggest that GCST may be used clinically fordeclining the accumultion of body fat with hyperlipidemia.