Effects of Agastache rugosa on Obesity Via Inhibition of Peroxisome Proliferator-Activated Receptor-Gamma and Reduction of Food Intake (지방합성 인자 조절 및 식이 섭취 감소를 통한 곽향의 항비만 효능)

김용민; Mi Hye Kim (김미혜); Yang Woong Mo (양웅모)

Effects of Agastache rugosa on Obesity Via Inhibition of Peroxisome Proliferator-Activated Receptor-Gamma and Reduction of Food Intake

Journal of Korean Medicine for Obesity Research
Abbr : J Korean Med Obes Res
2015, 15(2), pp.104-110
Publisher : The Society of Korean Medicine for Obesity Research
Research Area : Medicine and Pharmacy > Korean Medicine
Published : December 30, 2015

김용민 ¹, Mi Hye Kim ¹, Yang Woong Mo ¹

¹경희대학교

Candidate

ABSTRACT

Objectives: The herb of Agastache rugosa (AR) is a traditional herbal medicine used for colds,vomiting and furuncles. However, there are few reports to investigate the inhibitory effects of ARon obesity. In this study, the effects of AR on high fat diet (HFD)-induced obesity and itsmechanism of actions were investigated in experimental animals. Methods: The mice were fed HFD for 4 weeks to induce obesity. After randomly divided intonormal fat diet, HFD and AR groups, 200 mg/kg of AR was administrated for 4 weeks withcontinuous HFD feeding while vehicle was orally treated to HFD group. Food intake and bodyweight were recorded weekly. Results: Increased body weight by HFD was improved by AR treatment. AR administrationinhibited an increase of visceral fat weight as well as adipocyte hypertrophy. Hepatic steatosiswas ameliorated in AR-treated mice. In addition, treatment of AR attenuated the expression ofadipogenic transcription factor, peroxisome proliferator-activated receptor (PPAR)-gamma in theepididymal adipose tissue. Also the increased serum leptin level by HFD was maintained in ARgroup, leading to inhibition of food intake. Conclusions: AR treatment showed inhibitory effects on HFD-induced obesity by inhibition ofPPAR-gamma and reduction of food intake. AR could be an alternative treatment for obesity.

KEYWORDS

Herbal medicine, Obesity, Appetite regulation, Leptin, Peroxisome proliferatoractivated receptor gamma

Citation status

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