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Effects of Agastache rugosa on Obesity Via Inhibition of Peroxisome Proliferator-Activated Receptor-Gamma and Reduction of Food Intake

  • Journal of Korean Medicine for Obesity Research
  • Abbr : J Korean Med Obes Res
  • 2015, 15(2), pp.104-110
  • Publisher : The Society of Korean Medicine for Obesity Research
  • Research Area : Medicine and Pharmacy > Korean Medicine
  • Published : December 30, 2015

김용민 1 Mi Hye Kim 1 Woong Mo Yang 1

1경희대학교

Candidate

ABSTRACT

Objectives: The herb of Agastache rugosa (AR) is a traditional herbal medicine used for colds,vomiting and furuncles. However, there are few reports to investigate the inhibitory effects of ARon obesity. In this study, the effects of AR on high fat diet (HFD)-induced obesity and itsmechanism of actions were investigated in experimental animals. Methods: The mice were fed HFD for 4 weeks to induce obesity. After randomly divided intonormal fat diet, HFD and AR groups, 200 mg/kg of AR was administrated for 4 weeks withcontinuous HFD feeding while vehicle was orally treated to HFD group. Food intake and bodyweight were recorded weekly. Results: Increased body weight by HFD was improved by AR treatment. AR administrationinhibited an increase of visceral fat weight as well as adipocyte hypertrophy. Hepatic steatosiswas ameliorated in AR-treated mice. In addition, treatment of AR attenuated the expression ofadipogenic transcription factor, peroxisome proliferator-activated receptor (PPAR)-gamma in theepididymal adipose tissue. Also the increased serum leptin level by HFD was maintained in ARgroup, leading to inhibition of food intake. Conclusions: AR treatment showed inhibitory effects on HFD-induced obesity by inhibition ofPPAR-gamma and reduction of food intake. AR could be an alternative treatment for obesity.

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