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The Effects of Schizandrae Fructus Chloroform Fraction on Gene Expression in Liver Tissue of Dyslipidemic Mice

  • Journal of Korean Medicine for Obesity Research
  • Abbr : J Korean Med Obes Res
  • 2015, 15(2), pp.111-122
  • Publisher : The Society of Korean Medicine for Obesity Research
  • Research Area : Medicine and Pharmacy > Korean Medicine
  • Published : December 30, 2015

신윤리 1,  Young-kyun Kim 1,  Kyoung-min Kim 1

1동의대학교

Candidate

ABSTRACT

Objectives: Schizandrae fructus (Schizandra chinensis) is one of very common herbs, it is knownas natural antioxidants, anti-inflammatory agent. Also some reports show that its extract worksto regulate of dyslipidemia. This study was designed to investigate the effects of Schizandraefructus chloroform fraction (SFCF) on serum lipid levels in dyslipidemic mice. Methods: The levels of total cholesterol, high density lipoprotein-cholesterol, triglyceride,aspartate aminotransferase (AST), alanine aminotransferase (ALT), fasting blood glucose inserum were measured. Histopathological and gene expression changes in liver tissue were alsoobserved. Results: Oral administration of SFCF lowered levels of total cholesterol and triglyceride, whichwere elevated by high-fat diet. But SFCF did not affect on weight changes and serum AST, ALTlevels in dyslipidemic mice. After carrying out gene ontological analysis, large numbers of genesin high-fat diet group were up-(347) or down-regulated (235). In SFCF treated mice, somechanged expression of the genes was restored to normal levels, with a recovery rate of 17%. Andit seems that fatty acid biosynthesis pathway was one of important key pathways to recovery. Conclusions: SFCF has beneficial effect on dyslipidemia, and could be used to prevent and treatcardiovascular disease.

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