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The Effects of Cinnamomum cassia Blume, Aconitum carmichaeli Debx, and Pueraria lobata Benth on Glucose and Energy Metabolism in C2C12 Myotubes

  • Journal of Korean Medicine for Obesity Research
  • Abbr : J Korean Med Obes Res
  • 2015, 15(2), pp.131-136
  • Publisher : The Society of Korean Medicine for Obesity Research
  • Research Area : Medicine and Pharmacy > Korean Medicine
  • Published : December 30, 2015

송미영 1

1동국대학교

Candidate

ABSTRACT

Objectives: The prevalence of obesity and metabolic syndrome is increasing worldwide. Regulationof cellular energy metabolis has the potential to be manipulated therapeutically to serveas a target for obesity and insulin resistance. Skeletal muscle is regarded as a target for regulationof energy metabolism and insulin resistance. In this study, the authors investigated the regulatoryeffect of (Cinnamomum cassia Blume, CCB), Aconitum carmichaeli Debx (ACD), and Benth(Pueraria lobata Benth, PLB) on energy and glucose metabolism in C2C12 myotubes. Methods: The water extracts of CCB, ACD, and PLB (0.5 mg/ml) were treated in differentiatedC2C12 myotubes. The expressions of adenosine monophosphate-activated protein kinase(AMPK) and phosphorylation AMPK were detected with western blotting. Glucose metabolismwas investigated with glucose uptake assay and glucose consumption assay, total adenosinetriphosphate (ATP) content was also analyzed. Results: CCB, ACD, and PLB activated the phophorylation of AMPK, they also increased theglucose metabolism and total ATP contents in C2C12 myotubes. Conclusions: This study suggests that CCB, ACD, and PLB have the potential to increase energyand glucose metabolism in skeletal muscle.

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