Effects of Traditional Chinese Herbal Medicine Shengmai-San and Pyungwi-San on Gastrointestinal Motility in Mice (생맥산 및 평위산 추출물의 위장관 운동 조절 효능에 관한 연구)

이민철; 박진령; 심자환; 안태석; KIM, BYUNG JOO (김병주)

Effects of Traditional Chinese Herbal Medicine Shengmai-San and Pyungwi-San on Gastrointestinal Motility in Mice

Journal of Korean Medicine for Obesity Research
Abbr : J Korean Med Obes Res
2015, 15(2), pp.68-74
Publisher : The Society of Korean Medicine for Obesity Research
Research Area : Medicine and Pharmacy > Korean Medicine
Published : December 30, 2015

이민철 ¹, 박진령 ¹, 심자환 ¹, 안태석 ², KIM, BYUNG JOO ¹

¹부산대학교
²부산대학교 한의학전문대학원 양생기능의학부

Candidate

ABSTRACT

Objectives: The purpose of this study was to investigate the effects of Shengmai-san andPyungwi-san, a herbal product used in traditional Chinese medicine, on gastrointestinal (GI)motility in mice. Methods: The in vivo effects of Shengmai-san and Pyungwi-san on GI motility were investigatedby measuring the intestinal transit rates (ITRs) using Evans blue in normal mice and in mice withexperimentally induced GI motility dysfunction (GMD). GMD was induced by injecting acetic acidor streptozotocin intraperitoneally. Results: In normal Institute of Cancer Research mice, ITRs were significantly and dosedependentlyincreased by Shengmaisan (0.01∼1 g/kg) and Pyungwi-san (0.01∼1 g/kg). TheITRs of acetic acid induced peritoneal irritation model and streptozotocin-induced diabetic modelmice were significantly reduced compared to normal mice, and these reductions were significantlyand dose-dependently inhibited by Shengmai-san (0.01∼1 g/kg) and Pyungwi-san (0.01∼1g/kg). Conclusions: These results suggest that both Shengmai-san and Pyungwi-san are a goodcandidate for the development of a prokinetic agent that may prevent or alleviate GMD

KEYWORDS

Gastrointestinal disease, Shengmai-san, Pyungwi-san, Gastrointestinal motility, Gastrointestinal tract, Intestinal transit rate

Citation status

* References for papers published after 2023 are currently being built.

[journal] Cheng JT / 2000 / Review: drug therapy in Chinese traditional medicine / J Clin Pharmacol 40(5) : 445~450

[journal] Xu N / 2011 / HPLC/MS/MS for quantification of two types of neurotransmitters in rat brain and application: myocardial ischemia and protection of Sheng-Mai-San / J Pharm Biomed Anal 55(1) : 101~108

[journal] Nishida H / 2007 / Amyloid-β-induced cytotoxicity of PC- 12 cell was attenuated by Shengmai-san through redox regulation and outgrowth induction / J Pharmacol Sci 104(1) : 73~81

[journal] Wang NL / 2005 / Shengmai san, a Chinese herbal medicine protects against rat heat stroke by reducing inflammatory cytokines and nitric oxide formation / J Pharmacol Sci 98(1) : 1~7

[journal] Riedlinger JE / 2001 / Ping wei san, a Chinese medicine for gastrointestinal disorders / Ann Pharmacother 35(2) : 228~235

[journal] 이효승 / 2007 / Scavenging Property of Pyungwi-san Herbal-acupuncture Solution on ROS and RNS / 동의생리병리학회지 / 한의병리학회 21(1) : 165~170

[journal] 지현철 / 2011 / A Comparative Study of Pyeongwi-san, Ijin-tang and Pyeongjintang Extracts on Indomethacin-Induced Gastric Mucosal Lesions in Mice / 대한한의학회지 / 대한한의학회 32(2) : 102~117

[journal] 신인식 / 2010 / Study on Safety of Pyungwi-san in Sprague-Dawley Rats / 동의생리병리학회지 / 한의병리학회 24(3) : 426~429

[journal] Bytzer P / 2001 / Prevalence of gastrointestinal symptoms associated with diabetes mellitus: a population-based survey of 15,000 adults / Arch Intern Med 161(16) : 1989~1996

[journal] Maleki D / 2000 / Gastrointestinal tract symptoms among persons with diabetes mellitus in the community / Arch Intern Med 160(18) : 2808~2816

[journal] Camilleri M / 2007 / Clinical practice. Diabetic gastroparesis / N Engl J Med 356(8) : 820~829

[journal] Intagliata N / 2007 / Gastroparesis in type 2 diabetes mellitus:prevalence, etiology, diagnosis, and treatment / Curr Gastroenterol Rep 9(4) : 270~279

[journal] Chen JD / 1996 / Abnormal gastric myoelectrical activity and delayed gastric emptying in patients with symptoms suggestive of gastroparesis / Dig Dis Sci 41(8) : 1538~1545

[journal] Hasler WL / 1995 / Mediation of hyperglycemia-evoked gastric slow-wave dysrhythmias by endogenous prostaglandins / Gastroenterology 108(3) : 727~736

[journal] Jebbink RJ / 1994 / Hyperglycemia induces abnormalities of gastric myoelectrical activity in patients with type I diabetes mellitus / Gastroenterology 107(5) : 1390~1397

[journal] Sellin JH / 1992 / Glucose malabsorption associated with rapid intestinal transit / Am J Gastroenterol 87(5) : 584~589

[journal] Ward SM / 1994 / Mutation of the proto-oncogene c-kit blocks development of interstitial cells and electrical rhythmicity in murine intestine / J Physiol 480(Pt 1) : 91~97

[journal] Huizinga JD / 1995 / W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity / Nature 373(6512) : 347~349

[journal] Sanders KM / 1996 / A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract / Gastroenterology 111(2) : 492~515

[journal] 김정남 / 2013 / Modulation of Pacemaker Potentials by Pyungwi-San in Interstitial Cells of Cajal from Murine Small Intestine- Pyungwi-San and Interstitial Cells of Cajal - / Journal of Pharmacopuncture / 대한약침학회 16(1) : 43~49

[journal] 김병주 / 2013 / Shengmaisan Regulates Pacemaker Potentials in Interstitial Cells of Cajal in Mice / Journal of Pharmacopuncture / 대한약침학회 16(4) : 36~42

[journal] Kim BJ / 2013 / Poncirus trifoliate fruit modulates pacemaker activity in interstitial cells of Cajal from the murine small intestine / J Ethnopharmacol 149(3) : 668~675

[journal] Lee HT / 2005 / Prokinetic activity of an aqueous extract from dried immature fruit of Poncirus trifoliata (L.) Raf / J Ethnopharmacol 102(2) : 131~136

[journal] Ju Hyeong Lyu / 2013 / Effects of dried Citrus unshiu peels on gastrointestinal motility in rodents / Archives of Pharmacal Research / 대한약학회 36(5) : 641~648

[journal] Friese N / 1997 / Reversal by kappa-agonists of peritoneal irritation induced ileus and visceral pain in rats / Life Sci 60(9) : 625~634

[journal] Kim BJ / 2014 / Characteristics of gintonin-mediated membrane depolarization of pacemaker activity in cultured interstitial cells of Cajal / Cell Physiol Biochem 34(3) : 873~890

[journal] Furukawa Y / 1995 / Effect of Chinese herbal medicine on gastrointestinal motility and bowel obstruction / Jpn J Gastroenterol Surg 28(4) : 956~960

[journal] Hashimoto K / 2001 / Modulatory effect of aliphatic acid amides from Zanthoxylum piperitum on isolated gastrointestinal tract / Planta Med 67(2) : 179~181

[journal] Ahn TS / 2015 / Effects of Schisandra chinensis extract on gastrointestinal motility in mice / J Ethnopharmacol 169 : 163~169

[journal] Rhyu MR / 2006 / Aqueous extract of Schizandra chinensis fruit causes endotheliumdependent and -independent relaxation of isolated rat thoracic aorta / Phytomedicine 13(9-10) : 651~657

[journal] Hwang MW / 2015 / Effects of traditional Chinese herbal medicine San-Huang-Xie-Xin-Tang on gastrointestinal motility in mice / World J Gastroenterol 21(4) : 1117~1124

[journal] Kim BJ / 2014 / Effects of San-Huang-Xie-Xin-tang, a traditional Chinese prescription for clearing away heat and toxin, on the pacemaker activities of interstitial cells of Cajal from the murine small intestine / J Ethnopharmacol 155(1) : 744~752

[journal] Kim BJ / 2005 / Melastatin-type transient receptor potential channel 7 is required for intestinal pacemaking activity / Gastroenterology 129(5) : 1504~1517

[journal] Hwang SJ / 2009 / Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles / J Physiol 587(Pt20) : 4887~4904

[journal] Schvarcz E / 1996 / Increased prevalence of upper gastrointestinal symptoms in long-term type 1 diabetes mellitus / Diabet Med 12(5) : 478~481

[journal] Bytzer P / 2002 / GI symptoms in diabetes mellitus are associated with both poor glycemic control and diabetic complications / Am J Gastroenterol 97(3) : 604~611

[journal] Forrest A / 2008 / Increase in stretch-induced rhythmic motor activity in the diabetic rat colon is associated with loss of ICC of the submuscular plexus / Am J Physiol Gastrointest Liver Physiol 294(1) : G315~G326

[journal] Yamamoto T / 2008 / Disturbed gastrointestinal motility and decreased interstitial cells of Cajal in diabetic db/db mice / J Gastroenterol Hepatol 23(4) : 660~667

KJCKorea
Journal Central

Journal of Korean Medicine for Obesity Research 2023 KCI Impact Factor : 0.43