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A 8-Week, Randomized, Double-Blind, Placebo-Controlled Human Trial to Evaluate the Efficacy and Safety of Punica granatum L.ㆍ Actinidia chinensis Planch. Mixed Extract on Body Fat

  • Journal of Korean Medicine for Obesity Research
  • Abbr : J Korean Med Obes Res
  • 2017, 17(2), pp.87-95
  • Publisher : The Society of Korean Medicine for Obesity Research
  • Research Area : Medicine and Pharmacy > Korean Medicine
  • Published : December 30, 2017

choi jin bong 1 이지은 1 도윤경 1

1동신대학교

Accredited

ABSTRACT

Objectives: This study was conducted to evaluate efficacy and safety of Punica granatum L.ㆍActinidia chinensis Planch. mixed extract on body fat. Methods: Thirty women were recruited (25 kg/m2≤body mass index [BMI]≤29.9 kg/m2) (19 yr≤age≤38 yr) and randomized to receive Punica granatum L.ㆍActinidia chinensis Planch. mixedextract or placebo for 8 weeks. During the test, they visited four times including screening. Bodyfat mass, body fat rate, anthropometric dimensions at waist and hip, waist-hip ratio, totalcholesterol, triglyceride, low density lipoprotein-cholesterol (LDL-C), and high densitylipoprotein-cholesterol (HDL-C) were measured at screening and 8 weeks after screening. Adverse reaction were also checked each visit. Results: There were no significant differences in all index. But when divide experimental group byBMI index, age, and compliance, less than BMI 27 kg/m2 group decreased body weight, body fatmass and more than BMI 27 kg/m2 group also decreased body weight, body fat mass and waistcircumference. Less than age 30 years group showed decline of waist circumference, fat free rateand T-cholesterol and more than age 30 years group showed decline of fat free mass. Group withcompliance more than 95% was decreased BMI, fat free mass, and hip circumference. Conclusions: There was no significant efficacy as compared with placebo group, but as divideexperimental group according to BMI index, age, compliance, mixed extract might be effective toreduce obesity index.

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